In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 6, 1996, Pages 671-679

  Lecci, A ^a   Giuliani, S ^a   Tramontana, M ^a   Meini, S ^a   De Giorgio, R ^b   Maggi, C A ^a  

^a Menarini Ricerche SpA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Inhibitory neurotransmission; NANC; Nitric oxide; Senktide; SR 142,801

Indexed keywords

ATROPINE; GUANETHIDINE; HEXAMETHONIUM; MEN 10627; N(G) NITROARGININE METHYL ESTER; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ 3 RECEPTOR ANTAGONIST; NEUROKININ A; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; NOLPITANTIUM; OSANETANT; SENKTIDE; TACHYKININ RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; COLON DILATATION; COLON MOTILITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; ISOMER; MALE; NEUROTRANSMISSION; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PERISTALSIS; RAT; SMOOTH MUSCLE CONTRACTION;

ADRENERGIC AGENTS; ANIMALS; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANETHIDINE; HEXAMETHONIUM; MALE; MUSCLE CONTRACTION; NEUROKININ A; NG-NITROARGININE METHYL ESTER; NICOTINIC ANTAGONISTS; PEPTIDE FRAGMENTS; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-3; RECEPTORS, TACHYKININ; SUBSTANCE P;

EID: 0029940419     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00167186     Document Type: Article

References (25)

1. Barthó L, Holzer P (1985) Search for a physiological role of substance P in gastrointestinal motility. Neuroscience 16:1-32
2. Barthó L, Lefebvre RA (1994a) Nitric oxide causes contraction in the rat isolated small intestine. Eur J Pharmacol 259:101-104
3. Barthó L, Lefebvre RA (1994b) Nitric oxide induces acettylcholine-mediated contractions in the guinea-pig small intestine. Naunyn-Schmiedebcrg's Arch Pharmacol 350:582-584
4. Barthó L, Lefebvre RA (1995) Nitric oxide-mediated contraction in enteric smooth muscle. Arch Int Pharamacodyn 329:53-66
5. Barthó L, Koczan G, Petho G, Maggi CA (1992) Blockade of nitric oxide synthase inhibits nerve-mediated contraction in the rat small intestine. Neurosci Lett 145:43-46
6. 3 receptor. Life Sci 56: PL 27-32
7. Furness JB, Young HM, Pompolo S, Bornstein JC, Kunze WAA, McConalogue K (1995) Plurichemical transmission and chemical coding of neurons in the digestive tract. Gastroenterology 108:554-563
8. 3 receptor agonists in guinea-pig colon. Naunyn-Schmiedeberg's Arch Pharmacol 352:512-519
9. 3 receptor-mediated tachykinin release in the guinea-pig ileum. Eur J Pharmacol 144:409-412
10. Hellstrom PM, Soder O, Theodorsson E (1991) Occurrence, release and effects of multiple tachykinins in cat colonic tissue and nerves. Gastroenterology 100:431-440
11. ++ signaling pathways in intestinal muscle cells. J Pharmacol Exp Ther 270:236-243
12. Holzer-Petsche U (1995) Tachykinin receptors in gastrointestinal motility. Regul Pept 57:19-42
13. Jin JC, Misra S, Grider JR, Makhlouf GM (1993) Functional difference between SP and NKA: relaxation of gastric muscle by SP is mediated by VIP and NO. Am J Physiol 264: G678-G685
14. Laufer R, Wormser U, Friedman ZY, Gilon C, Chorev M, Selinger Z (1986) Neurokinin B is a preferred agonist for neuronal substance P receptor and its action is antagonized by enkephalin. Proc Natl Acad Sci USA 82:7444-7447
15. 3 receptor-induced relaxation in the circular muscle of the guinea-pig ileum. Eur J Pharmacol 240:45-50
16. Maggi CA, Patacchini R, Meini S, Giuliani S (1994a) Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum. J Auton Pharmacol 14:49-60
17. 3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon. Regul Pept 53:259-274
18. Moussaoui SM, Le Prado N, Bonici B, Faucher C, Cuiné F, Laduron PM, Garret C (1992) Distribution of neurokinin B in rat spinal cord and peripheral tissues: comparison with neurokinin A and substance P and effects of neonatal capsaicin treatment. Neuroscience 48:969-978
19. Mussap CJ, Geraghty DP, Burcher E (1993) Tachykinin receptors: a radioligand binding perspective. J Neurochem 60:1987-2009
20. Patacchini R, Barthò L, Holzer P, Maggi CA (1995) Activity of SR 142,801 at peripheral tachykinin receptors, Eur J Pharmacol 278:17-25
21. Shuttleworth CWR, Keef KD (1995) Roles of peptides in enteric neuromuscolar transmission. Regul Pept 56:101-120
22. Sternini C, Anderson K, Frantz G, Krause JE, Brecha NS (1989) Expression of SP/NKA-cncoding preprotachykinin messenger RNA in rat enteric nervous system. Gastroenterology 97:348-356
23. Tateishi K, Kishimoto S, Kobayashi H, Kokube K, Matsuoka Y (1990) Distribution and localization of neurokinin A-like immunoreactivity and neurokinin B-like immunoreactivity in rat peripheral tissues. Regul Pept 30:193-200
24. Wormser U, Laufer R, Hart Y, Chorev M, Gilon C, Selinger Z (1986) Highly selective agonists for substance P receptor subtypes. EMBO J 5:2805-2808
25. Yau WM, Mandel KG, Dorsett JA, Youther ML (1992) Neurokinin-3 receptor regulation of acethylcholine release from myenteric plexus. Am J Physiol 263:G569-G664