Optimization and scale-up of a fluid bed tangential spray rotogranulation process

International Journal of Pharmaceutics

Volumn 335, Issue 1-2, 2007, Pages 54-62

  Bouffard, J ^a   Dumont, H ^b   Bertrand, F ^a   Legros, R ^a  

^a ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Granulation; Pellets; Process optimization; Rotogranulator; Scale up

Indexed keywords

AIRFLOW; ARTICLE; ATMOSPHERIC PRESSURE; BINDING KINETICS; DEGRADATION KINETICS; DRUG GRANULATION; FLOW RATE; FLUID BED ROTOGRANULATION; FLUID FLOW; MULTIPLE REGRESSION; NEBULIZATION; PARTICLE SIZE; PELLET EXTRUSION; PHARMACEUTICAL ENGINEERING; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCALE UP; SPHERONIZATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; FACTOR ANALYSIS, STATISTICAL; LACTOSE; LINEAR MODELS; MODELS, STATISTICAL; PARTICLE SIZE; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 33947594314     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.11.022     Document Type: Article

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