Comparative study of topical anti-allergic eye drops on human conjunctiva-derived cells: Responses to histamine and IFNγ and toxicological profiles

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 245, Issue 4, 2007, Pages 534-546

  Pauly, Aude ^a,c   Brignole Baudouin, Françoise ^a,b,c   Guenoun, Jean Marc ^a,b   Riancho, Luisa ^a,c   Rat, Patrice ^a,c   Warnet, Jean Michel ^a,c   Baudouin, Christophe ^a,b,d  

^a INSERM   (France)

^b CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Allergy; Cytokine; Drugs; Toxicology

Indexed keywords

ALERDUAL; ANTIALLERGIC AGENT; AZELASTINE; BENZALKONIUM CHLORIDE; CROMABAK; CROMOGLYCATE DISODIUM; EPINASTINE; GAMMA INTERFERON; HISTAMINE; HYDROETHIDINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; KETOTIFEN; KETOTIFEN FUMARATE; LEVOCABASTINE; LEVOPHTA; NEUTRAL RED; OLOPATADINE; OXYGEN; PROPIDIUM IODIDE; PURIVIST; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL STIMULATION; CELL VIABILITY; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CULTURE MEDIUM; CYTOFLUOROMETRY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG FORMULATION; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOMODULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICITY TESTING;

ADMINISTRATION, TOPICAL; ANTI-ALLERGIC AGENTS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CONJUNCTIVA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FLOW CYTOMETRY; HISTAMINE; HISTAMINE H1 ANTAGONISTS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; INTERLEUKIN-6; INTERLEUKIN-8; OPHTHALMIC SOLUTIONS; PEROXIDES; PRESERVATIVES, PHARMACEUTICAL; REACTIVE OXYGEN SPECIES;

EID: 33947594046     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-006-0353-z     Document Type: Article

References (66)

1. Abelson MB, Chambers WA, Smith LM (1990) Conjunctival allergen challenge. A clinical approach to studying allergic conjunctivitis. Arch Ophthalmol 108:84-88
2. Abelson MB, Schaefer K (1993) Conjunctivitis of allergic origin: immunologic mechanisms and current approaches to therapy. Surv Ophthalmol 38(Suppl):115-132
3. Abelson MB, Loeffler O (2003) Conjunctival allergen challenge: Models in the investigation of ocular allergy. Curr Allergy Asthma Rep 3:363-368
4. Abelson MB (2004) A review of olopatadine for the treatment of ocular allergy. Exp Opin Pharmacother 5:1979-1994
5. Abelson MB, Gomes P, Crampton HJ, Schiffman RM, Bradford RR, Whitcup SM (2004) Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis. Clin Ther 26:35-47
6. Bachert C (1998) Histamine-a major role in allergy? Clin Exp Allergy 28(Suppl 6):15-19
7. Bagnasco M, Pesce G, Fiorino N, Riccio AM, Ciprandi G, Buscaglia S, Canonica GW (1997) In situ hybridization analysis of ICAM-1 (CD54) mRNA on conjunctival epithelium during allergic inflammation. Clin Exp Allergy 27:737-743
8. Baudouin C, Hamard P, Liang H, Creuzot-Garcher C, Bensoussan L, Brignole F (2004) Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term. Ophthalmology 111:2186-2192
9. Baudouin C, Liang H, Bremond-Gignac D, Hamard P, Hreiche R, Creuzot-Garcher C, Warnet JM, Brignole-Baudouin F (2005) CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1/ T(H)2 in ocular surface disorders. J Allergy Clin Immunol 116:614-619
10. Belloc F, Dumain P, Boisseau MR, Jalloustre C, Reiffers J, Bernard P, Lacombe F (1994) A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells. Cytometry 17:59-65
11. Brignole-Baudouin F, Ott AC, Warnet JM, Baudouin C (2004) Flow cytometry in conjunctival impression cytology: A new tool for exploring ocular surface pathologies. Exp Eye Res 78:473-481
12. Buscaglia S, Paolieri F, Catrullo A, Fiorino N, Riccio AM, Pesce G, Montagna P, Bagnasco M, Ciprandi G, Canonica GW (1996) Topical ocular levocabastine reduces ICAM-1 expression on epithelial cells both in vivo and in vitro. Clin Exp Allergy 26:1188-1196
13. Calder VL, Jolly G, Hingorani M, Adamson P, Leonardi A, Secchi AG, Buckley RJ, Lightman S (1999) Cytokine production and mRNA expression by conjunctival T-cell lines in chronic allergic eye disease. Clin Exp Allergy 29:1214-1222
14. Calderon E, Lockey RF (1992) A possible role for adhesion molecules in asthma. J Allergy Clin Immunol 90:852-865
15. Canonica GW, Ciprandi G, Buscaglia S, Pesce G, Bagnasco M (1994) Adhesion molecules of allergic inflammation: Recent insights into their functional roles. Allergy 49:135-141
16. Canonica GW, Ciprandi G, Passalacqua G, Pesce G, Scordamaglia A, Bagnasco M (1997) Molecular events in allergic inflammation: experimental models and possible modulation. Allergy 52:25-30
17. Canonica GW (1997) Adhesion molecules in allergy. J Invest Allergol Clin Immunol 7:274-276
18. 1-antihistamines. Clin Exp Allergy 27(Suppl 2):19-27; discussion 54-56
19. Ciprandi G, Buscaglia S, Pesce G, Villaggio B, Bagnasco M, Canonica GW (1993) Allergic subjects express intercellular adhesion molecule-1 (ICAM-1 or CD54) on epithelial cells of conjunctiva after allergen challenge. J Allergy Clin Immunol 91:783-792
20. Ciprandi G, Pronzato C, Ricca V, Passalacqua G, Bagnasco M, Canonica GW (1994) Allergen-specific challenge induces intercellular adhesion molecule 1 (ICAM-1 or CD54) on nasal epithelial cells in allergic subjects. Relationships with early and late inflammatory phenomena. Am J Respir Crit Care Med 150:1653-1659
21. Ciprandi G, Pronzato C, Passalacqua G, Ricca V, Grogen J, Mela GS, Varese P, Bertolini C, Bagnasco M, Canonica GW (1996) Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: An antiallergic activity. J Allergy Clin Immunol 98:1088-1096
22. Ciprandi G, Cosentino C, Milanese M, Tosca MA (2003) Rapid anti-inflammatory action of azelastine eyedrops for ongoing allergic reactions. Ann Allergy Asthma Immunol 90:434-438
23. Ciprandi G, Tosca MA, Cosentino C, Riccio AM, Passalacqua G, Canonica GW (2003) Effects of fexofenadine and other antihistamines on components of the allergic response: Adhesion molecules. J Allergy Clin Immunol 112:S78-S82
24. Cook EB, Stahl JL, Barney NP, Graziano FM (2001) Olopatadine inhibits anti-immunoglobulin E-stimulated conjunctival mast cell upregulation of ICAM-1 expression on conjunctival epithelial cells. Ann Allergy Asthma Immunol 87:424-429 424-429
25. Cvenkel B, Ihan A (2002) Ocular surface changes induced by topical antiglaucoma monotherapy. Ophthalmologica 216:175-179
26. Debbasch C, Pisella PJ, Rat P, Warnet JM, Baudouin C (2001) Antioxidant effects of mast cell inhibitors in a human conjunctival cell line. J Fr Ophtalmol 24:121-128
27. Debbasch C, Brignole F, Pisella PJ, Warnet JM, Rat P, Baudouin C (2001) Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells. Invest Ophthalmol Vis Sci 42:642-652
28. Debbasch C, Pisella PJ, De Saint Jean M, Rat P, Warnet JM, Baudouin C (2001) Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta-blockers on Chang conjunctival cells. Invest Ophthalmol Vis Sci 42:2525-2533
29. Debbasch C, De La Salle SB, Brignole F, Rat P, Warnet JM, Baudouin C (2002) Cytoprotective effects of hyaluronic acid and Carbomer 934P in ocular surface epithelial cells. Invest Ophthalmol Vis Sci 43:3409-3415
30. De Saint Jean M, Brignole F, Feldmann G, Goguel A, Baudouin C (1999) Interferon-gamma induces apoptosis and expression of inflammation-related proteins in Chang conjunctival cells. Invest Ophthalmol Vis Sci 40:2199-2212
31. De Saint Jean M, Brignole F, Bringuier AF, Bauchet A, Feldmann G, Baudouin C (1999) Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci 40:619-630
32. De Saint Jean M, Debbasch C, Brignole F, Rat P, Warnet JM, Baudouin C (2000) Toxicity of preserved and unpreserved antiglaucoma topical drugs in an in vitro model of conjunctival cells. Curr Eye Res 20:85-94
33. De Saint Jean M, Baudouin C, Di Nolfo M, Roman S, Lozato P, Warnet JM, Brignole F (2004) Comparison of morphological and functional characteristics of primary-cultured human conjunctival epithelium and of Wong-Kilbourne derivative of Chang conjunctival cell line. Exp Eye Res 78:257-274
34. Fujihara T, Takeuchi T, Saito K, Tsubota K (1997) Flow cytometric analysis of surface antigens on human conjunctival epithelial cells. Ophthalm Res 29:103-109
35. Gamache DA, Dimitrijevich SD, Weimer LK, Lang LS, Spellman JM, Graff G, Yanni JM (1997) Secretion of proinflammatory cytokines by human conjunctival epithelial cells. Ocul Immunol Inflamm 5:117-128
36. Garrelds IM, de Graaf-in't Veld T, van Toorenenbergen AW, van Wijk RG, Boegheim JP, Saxena PR, Zijlstra FJ (1996) Selective effect of levocabastine on histamine receptor and histamine release from human leukocytes and guinea pig isolated tissue. Ann Allergy Asthma Immunol 76:327-334
37. Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F (2005) In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci 46:2444-2450
38. Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F (2005) In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci 46:4594-4599
39. Guglielminetti E, Barabino S, Monaco M, Mantero S, Rolando M (2002) HLA-DR expression in conjunctival cells after latanoprost. J Ocul Pharmacol Ther 18:1-9
40. Hingorani M, Calder VL, Buckley RJ, Lightman SL (1998) The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp Eye Res 67:491-500
41. Irkec M, Bozkurt B (2003) Epithelial cells in ocular allergy. Curr Allergy Asthma Rep 3:352-357
42. Jambou D, Lapalus P (1990) Effect of N-acetyl-aspartyl-glutamate (Naaga) on in-vitro leukotriene synthesis by macrophage cell line P388D1. Int J Tissue React 12:273-280
43. Leonardi A, DeFranchis G, Zancanaro F, Crivellari G, De Paoli M, Plebani M, Secchi AG (1999) Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry. Invest Ophthalmol Vis Sci 40:3036-3040
44. Leonardi A, DeFranchis G, De Paoli M, Fregona I, Plebani M, Secchi A (2002) Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblasts. Curr Eye Res 25:189-196
45. Martin AP, Urrets-Zavalia J, Berra A, Mariani AL, Gallino N, Gomez Demel E, Gagliardi J, Baena-Cagnani CE, Urrets-Zavalia E, Serra HM (2003) The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study. BMC Ophthalmol 3:2
46. Matsukura M, Yajima A, Yamazaki F, Yudate T, Yamada H, Tezuka T (2003) Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis. Skin Pharmacol Appl Skin Physiol 16:405-410
47. Metz DP, Hingorani M, Calder VL, Buckley RJ, Lightman SL (1997) T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol 100:817-824
48. Miki I, Kusano A, Ohta S, Hanai N, Otoshi M, Masaki S, Sato S, Ohmori K (1996) Histamine enhanced the TNF-alpha-induced expression of E-selectin and ICAM-1 on vascular endothelial cells. Cell Immunol 171:285-288
49. Montefort S, Holgate ST (1991) Adhesion molecules and their role in inflammation. Respir Med 85:91-99
50. Paolieri F, Battifora M, Riccio AM, Pesce G, Canonica GW, Bagnasco M (1997) Intercellular adhesion molecule-1 on cultured human epithelial cell lines: Influence of proinflammatory cytokines. Allergy 52:521-531
51. Paolieri F, Battifora M, Riccio AM, Bertolini C, Cutolo M, Bloom M, Ciprandi G, Canonica GW, Bagnasco M (1998) Terfenadine and fexofenadine reduce in vitro ICAM-1 expression on human continuous cell lines. Ann Allergy Asthma Immunol 81:601-607
52. Patalano F, Ruggieri F (1989) Sodium cromoglycate: A review. Eur Respir J Suppl 6:556s-560s
53. Pisella PJ, Fillacier K, Elena PP, Debbasch C, Baudouin C (2000) Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits. Ophthalm Res 32:3-8
54. Pisella PJ, Debbasch C, Hamard P, Creuzot-Garcher C, Rat P, Brignole F, Baudouin C (2004) Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: An ex vivo and in vitro study. Invest Ophthalmol Vis Sci 45:1360-1368
55. Schoch C (2003) Effects of ketotifen 0.025% and lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis. J Ocul Pharmacol Ther 19:153-159
56. Sharif NA, Xu SX, Magnino PE, Pang IH (1996) Human conjunctival epithelial cells express histamine-1 receptors coupled to phosphoinositide turnover and intracellular calcium mobilization: Role in ocular allergic and inflammatory diseases. Exp Eye Res 63:169-178
57. Smit EE, Sra SK, Grabowski LR, Ward SL, Trocme SD (2003) Modulation of IL-8 and RANTES release in human conjunctival epithelial cells: Primary cells and cell line compared and contrasted. Cornea 22:332-337
58. Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425-434
59. Stahl JL, Cook EB, Graziano FM, Barney NP (2003) Differential and cooperative effects of TNFalpha, IL-1beta, and IFNgamma on human conjunctival epithelial cell receptor expression and chemokine release. Invest Ophthalmol Vis Sci 44:2010-2015
60. Triggiani M, Gentile M, Secondo A, Granata F, Oriente A, Taglialatela M, Annunziato L, Marone G (2001) Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H 1 receptors. J Immunol 166:4083-4091
61. Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R (1990) Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science 247:456-459
62. Weimer LK, Gamache DA, Yanni JM (1998) Histamine-stimulated cytokine secretion from human conjunctival epithelial cells: Inhibition by the histamine H 1 antagonist emedastine. Int Arch Allergy Immunol 115:288-293
63. White MV (1990) The role of histamine in allergic diseases. J Allergy Clin Immunol 86:599-605
64. Yanni JM, Miller ST, Gamache DA, Spellman JM, Xu S, Sharif NA (1997) Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells. Ann Allergy Asthma Immunol 79:541-545
65. Yanni JM, Weimer LK, Sharif NA, Xu SX, Gamache DA, Spellman JM (1999) Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs. Arch Ophthalmol 117:643-647
66. Zhan H, Towler HM, Calder VL (2003) The immunomodulatory role of human conjunctival epithelial cells. Invest Ophthalmol Vis Sci 44:3906-3910