In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 12, 2005, Pages 4594-4599

  Guenoun, Jean Marc ^a,b,c   Baudouin, Christophe ^a,b,c   Rat, Patrice ^c,d   Pauly, Aude ^c   Warnet, Jean Michel ^c,d   Brignole Baudouin, Françoise ^c,d  

^a CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGLAUCOMA AGENT; BENZALKONIUM CHLORIDE; BIMATOPROST; DICHLORODIHYDROFLUORESCEIN DIACETATE; FLUORESCENT DYE; HYDROETHIDINE; HYDROGEN PEROXIDE; LATANOPROST; NEUTRAL RED; OXYGEN RADICAL; PRESERVATIVE; PROSTAGLANDIN DERIVATIVE; TRAVOPROST; UNCLASSIFIED DRUG; YOPRO 1; AMIDE; ANTIHYPERTENSIVE AGENT; ANTIOXIDANT; BENZALKONIUM; CLOPROSTENOL; DRUG DERIVATIVE; LIPID; PROSTAGLANDIN F; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL LINE; CELL MEMBRANE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; DILUTION; DRUG EFFECT; DRUG EFFICACY; EPITHELIUM CELL; HUMAN; HUMAN CELL; INTRAOCULAR HYPERTENSION; PRIORITY JOURNAL; CELL SURVIVAL; COMPARATIVE STUDY; CONJUNCTIVA; CYTOLOGY; FLUOROMETRY; METABOLISM;

AMIDES; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; APOPTOSIS; BENZALKONIUM COMPOUNDS; CELL LINE; CELL SURVIVAL; CLOPROSTENOL; CONJUNCTIVA; CYTOPROTECTION; EPITHELIAL CELLS; FLUOROMETRY; HUMANS; HYDROGEN PEROXIDE; LIPIDS; PRESERVATIVES, PHARMACEUTICAL; PROSTAGLANDINS F, SYNTHETIC; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 33644800235     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0776     Document Type: Article

References (22)

1. Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F. In vitro study of inflammatory potential and toxicity profile between latanoprost, travoprost and bimatoprost on conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci. 2005;46:2444-2450.
2. Pisella PJ, Debbasch C, Hamard P, et al. Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest Ophthalmol Vis Sci. 2004;45:1360-1368.
3. Mietz H, Niesen U, Krieglstein GK. The effects of preservatives and antiglaucomatous medication on histopathology of the conjunctiva. Graefes Arch Clin Exp Ophthalmol. 1994;232:561-565.
4. Becquet F, Goldschild M, Moldovan MS, et al. Histopathological effects of topical ophthalmic preservatives on rat corneoconjunctival surface. Curr Eye Res. 1998;17:419-425.
5. Debbasch C, Pisella PJ, De Saint Jean M, et al. Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta blockers on Chang conjunctival cells. Invest Ophthalmol Vis Sci. 2001;42:2525-2533.
6. Debbasch C, Brignole F, Pisella PJ, Warnet JM, Rat P, Baudouin C. Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells. Invest Ophthalmol Vis Sci. 2001;42:642-652.
7. Ilzecka J. Prostaglandin E2 is increased in amyotrophic lateral sclerosis patients. Acta Neurol Scand. 2003;108:125-129.
8. Garg TK, Chang JY. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxydelta 12, 14-PGJ2. BMC Ophthalmol. 2003 March 21;3:5.
9. Garg TK, Chang JY. 15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. BMC Pharmacol. 2004 May 18;4:6.
10. Martinez J, Moreno JJ. Role of Ca2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species. Arch Biochem Biophys. 2001;15:392:257-262.
11. Martinez J, Moreno JJ. Influence of superoxide radical and hydrogen peroxide on arachidonic acid mobilization. Arch Biochem Biophys. 1996;15:336:191-198.
12. Ferreira SM, Lerner SF, Brunzini R, Evelson PA, Llesuy SF. Oxidative stress markers in aqueous humor of glaucoma patients. Am J Ophthalmol. 2004;137:62-69.
13. Yildirim O, Ates NA, Ercan B, et al. Role of oxidative stress enzymes in open-angle glaucoma. Eye 2005;19:580-583.
14. Izzotti A, Sacca SC, Cartiglia C, De Flora S. Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am J Med. 2003;114:638-646.
15. Plantin-Carrenard E, Bringuier A, Derappe C, et al. A fluorescence microplate assay using yopro-1 to measure apoptosis: application to HL60 cells subjected to oxidative stress. Cell Biol Toxicol. 2003;19:121-133.
16. Borenfreund E, Puerner JA. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). J Tissue Cult Methods. 1984;9:7-9.
17. Rat P, Osseni R, Christen MO, Thevenin M, Warnet J-M, Adolphe M. Microtitration fluorimetric assays on living cells (MiFALC tests): new tools for screening in cell pharmacotoxicology. In: Van Zutphen LFM, Balls M, eds. Animal Alternatives, Welfare and Ethics. Paris: Elsevier; 1997:813-825.
18. Budd SL, Castilho RF, Nicholls DG. Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells. FEBS Lett. 1997;415:21-24.
19. Idziorek T, Estaquier J, De Bels F, Ameisen JC. YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability. J Immunol Methods. 1995;185:249-258.
20. Suh BC, Kim JS, Namgung U, Ha H, Kim KT. P2X7 nucleotide receptor mediation of membrane pore formation and superoxide generation in human promyelocytes and neutrophils. J Immunol. 2001;166:6754-6763.
21. Gibbons SJ, Washburn KB, Talamo BR. P2X(7) receptors in rat parotid acinar cells: formation of large pores. J Auton Pharmacol. 2001;21:181-190.
22. Sznitowska M, Janicki S, Dabrowska EA, Gajewska M. Physicochemical screening of antimicrobial agents as potential preservatives for submicron emulsions. Eur J Pharm Sci. 2002;15:489-495.