Effects of ketotifen 0.025% and Lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis

Journal of Ocular Pharmacology and Therapeutics

Volumn 19, Issue 2, 2003, Pages 153-159

  Schoch, Christian ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

KETOTIFEN; KETOTIFEN FUMARATE; LODOXAMIDE; LODOXAMIDE TROMETAMOL;

ALLERGIC CONJUNCTIVITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EOSINOPHIL; GUINEA PIG; INFLAMMATORY INFILTRATE; LEUKOCYTE MIGRATION; NONHUMAN;

EID: 0038303188     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/108076803321637681     Document Type: Article

References (13)

1. Morley, J., Sanjar, S., and Page, C.P. The platelet in asthma. Lancet 2:1142-1144, 1984.
2. Bonini, S., Magrini, L., Rotiroti, G., Lambiase, A., Tomassini, M., Rumi, C., and Bonini, S. The eosinophil and the eye. Allergy 52:44-47, 1997.
3. Grant, S.M., Goa, K.L., Fitton, A., and Sorkin, E.M. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs 40:412-448, 1990.
4. Sanjar, S., Aoki, S., Boubekeur, K., Burrows, L., Colditz, I., Chapman, I., and Morley, J. Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by antiasthma drugs. Jpn. J. Pharmacol. 51:167-172, 1989.
5. Morley, J., Page, C.P., Mazzoni, L., and Sanjar, S. Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. Ann. Allergy 56:335-340, 1986.
6. Bonini, S., Schiavone, M., Bonini, S., Magrini, L., Lischetti, P., Lambiase, A., and Bucci, M.G. Efficacy of lodoxamide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis. Ophthalmology 104(5):849-853, 1997.
7. Lindor, L.J., Loegering, D.A., Wassom, D.L., and Gleich, G.J. Recovery of eosinophils from the peritoneal cavity of the guinea pig. J. Immunol. Methods 41:125-134, 1981.
8. Chan, C.C., McKee, K., Tagari, P., Chee, P., and Ford-Hutchinson, A. Eosinophil-eicosanoid interactions: inhibition of eosinophil chemotaxis in vivo by a LTD4-receptor antagonist. Eur. J. Pharmacol. 191:273-280, 1990.
9. Leuschner, P.J. Influence on eosinophil infiltration into the guinea pig conjunctiva by ketotifen 0.025% and lodoxamide 0.1% in a model of ocular immediate hypersensitivity. Novartis Ophthalmics AG, LPT Report No. 12192/99, 1999.
10. Arnoux, B., Denjean, A., Page, C.P., Nolibe, D., Morley, J., and Benveniste, J. Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. Am. Rev. Respir. Dis. 137:855-860, 1988.
11. Guibout, P., Choffel, C., Constans, P., Fabre, C., and Robillard, M. Efficacy of ketotifen in adult asthmatic patients: a 6-month double-blind versus placebo study. Respiration 46(Suppl.):20, 1984.
12. Podleski, W.K., Zelenak, T.M., and Schmidt, J.L. Long term trial of ketotifen in bronchial asthma. Ann. Allergy 52:406-410, 1984.
13. Abelson, M.B., Chapin, M.J., Kapik, B.M. and Shams, N. Ocular tolerance and safety of ketotifen fumarate ophthalmic solution compared with placebo. Advan Therap 19(4):161-169, 2002.