Trichostatin A and 5-aza-2′-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors

Cancer Letters

Volumn 250, Issue 1, 2007, Pages 53-62

  Koh, Eunjin ^a   Bandle, Russell ^a   Clair, Timothy ^a   Roberts, David D ^a   Stracke, Mary L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Epigenetic; Motility; S1P1; S1P2; S1P3; Sphingosine 1 phosphate; Trichostatin A

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE INHIBITOR; GENE PRODUCT; HISTONE DEACETYLASE INHIBITOR; LYSOPHOSPHATIDIC ACID RECEPTOR; SPHINGOSINE 1 PHOSPHATE 1; SPHINGOSINE 1 PHOSPHATE 2; SPHINGOSINE 1 PHOSPHATE 3; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL FUNCTION; CELL MOTILITY; CHEMOTAXIS; CONTROLLED STUDY; DEMETHYLATION; DRUG MECHANISM; EPIGENETICS; GENETIC REGULATION; HUMAN; HUMAN CELL; MELANOMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

AZACITIDINE; CELL LINE, TUMOR; CELL MOVEMENT; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; HYDROXAMIC ACIDS; LYSOPHOSPHOLIPIDS; MELANOMA; NERVE TISSUE PROTEINS; RECEPTORS, LYSOPHOSPHOLIPID; RECEPTORS, LYSOSPHINGOLIPID; RNA, MESSENGER; RNA-BINDING PROTEINS; SPHINGOSINE;

EID: 33947591523     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.09.017     Document Type: Article

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