Aspirin may exert its antipyresis by inhibiting the N-methyl-D-aspartate receptor-dependent hydroxyl radical pathways in the hypothalamus

Journal of Pharmacological Sciences

Volumn 103, Issue 3, 2007, Pages 293-298

  Kao, Ting Yu ^a,b   Huang, Wu Tein ^c   Chang, Ching Ping ^d   Lin, Mao Tsun ^e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c DIWAN COLLEGE OF MANAGEMENT   (Taiwan)

^d SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Aspirin; Fever; Glutamate; Hydroxyl radical; Lipopolysaccharide

Indexed keywords

ACETYLSALICYLIC ACID; HYDROXYL RADICAL; LIPOPOLYSACCHARIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPYRETIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEVER; HYPOTHALAMUS; MALE; MICRODIALYSIS; NONHUMAN; RABBIT; RECEPTOR BLOCKING;

EID: 33947535676     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0061460     Document Type: Article

References (26)

1. Huang WT, Lin MT, Chang CP. A NMDA receptor-dependent hydroxyl radical pathway in the rabbit hypothalamus may mediate lipopolysaccharide fever. Neuropharmacology. 2006;50:504-511.
2. Tsai CC, Lin MT, Wang JJ, Liao JF, Huang WT. The antipyretic effects of baicalin in lipopolysaccharide-evoked fever in rabbits. Neuropharmacology. 2006;51:709-717.
3. Huang WT, Wang JJ, Lin MT. Cyclooxygenase inhibitors attenuate augmented glutamate release in organum vasculosum laminae terminalis and fever induced by staphylococcal enterotoxin A. J Pharmacol Sci. 2004;94:192-196.
4. Huang WT, Wang JJ, Lin MT. Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits. Neurosci Lett. 2004;355:33-36.
5. Riedel W, Lang U, Oetjen U, Schlapp U, Shibata M. Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide-induced fever. Mol Cell Biochem. 2003;247:83-94.
6. Sawyer GH, Everett JW, Green JD. The rabbit diencephalons in stereotaxic coordinates. J Comp Neurol. 1954;101:801-824.
7. Hassoun HT, Kozar RA, Kone BC, Safi HJ, Moore FA. Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia/reperfusion. Surgery. 2002;32:369-376.
8. Yang CY, Lin MT. Oxidative stress in rats with heatstroke-induced cerebral ischemia. Stroke. 2002;33:790-794.
9. Romanovsky AA, Simons CT, Kulchitsky VA. "Biphasic" fevers often consist of more than two phases. Am J Physiol. 1998;275:R323-R331.
10. Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res. 2004;10:201-222.
11. Blatteis CM, Li S, Li Z, Feleder C, Perlik V. Cytokines, PGE2 and endotoxic fever: a re-assessment. Prostaglandins Other Lipid Mediat. 2005;6:1-18.
12. Shi X, Ding M, Dong Z, Chen F, Ye J, Wang S, et al. Antioxidant properties of aspirin: characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-kappaB activation, and TNF-alpha production. Mol Cell Biochem. 1999;99:93-102.
13. Yang CS, Tsai PJ, Lin NN, Liu L, Kuo JS. Elevated extracellular glutamate levels increased the formation of hydroxyl radical in the striatum of anesthetized rat. Free Rad Biol Med. 1995;19:453-459.
14. Jansky L, Vybiral S, Pospisilova D, Roth J, Dornand J, Zeisberger E, et al. Production of systemic and hypothalamic cytokines during the early phase of endotoxin fever. Neuroendocrinology. 1995;62:55-61.
15. Kakizaki Y, Watanobe H, Kohsaka A, Suda T. Temporal profiles of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the plasma and hypothalamic paraventricular nucleus after intravenous or intraperitoneal administration of lipopolysaccharide in the rat: estimation by push-pull perfusion. Endocrinol J. 1999;46:487-496.
16. Roth J, Conn CA, Kluger MJ, Zeisberger E. Kinetics of systemic and intrahypothalamic IL-6 and tumor necrosis factor during endotoxin fever in guinea pigs. Am J Physiol. 1993;265:R653-R658.
17. Banks WA, Kastin AJ, Broadwell RD. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation. 1995;2:241-248.
18. Buller KM. Role of circumventricular organs in pro-inflammatory cytokine-induced activation of the hypothalamic-pituitary-adrenal axis. Clin Exp Pharmacol Physiol. 2001;28:581-589.
19. Takahashi Y, Smith P, Ferguson A, Pittman QJ. Circumventricular organs and fever. Am J Physiol. 1997;273:R1690-R1695.
20. Roth J, Martin D, Storr B, Zeisberger E. Neutralization of pyrogen-induced tumour necrosis factor by its type 1 souble receptor in guinea-pigs: effects on fever and interleukin-6 release. J Physiol. 1998;509:267-275.
21. Lin JH, Lin MT. Nitric oxide synthase-cyclo-oxygenase pathways in organum vasculosum laminae terminalis: possible role in pyrogenic fever in rabbits. Br J Pharmacol. 1996;118:179-185.
22. Huang WT, Lin MT, Won SJ. Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits. Neurosci Lett. 1997;236:53-56.
23. Lee JJ, Huang WT, Shao DZ, Liao JF, Lin MT. Blocking NF-kappaB activation may be an effective strategy in the fever therapy. Jpn J Physiol. 2003;53:367-375.
24. Shao DZ, Lee JJ, Huang WT, Liao JF, Lin MT. Inhibition of nuclear factor-kappa B prevents staphylococcal enterotoxin A-induced fever. Mol Cell Biochem. 2004;262:177-185.
25. Asehnoune K, Strassheim D, Mitra S, Kim JY, Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol. 2004;172:2522-2529.
26. Chatterjee U, Sanwal GG. Purification and characterization of catalase from goat (Capra capra) lung. Mol Cell Biochem. 1993;26:125-133.