Mapping of human autoantibody epitopes on aromatic L-amino acid decarboxylase

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 3, 2007, Pages 1096-1105

  Candeloro, Paola ^a   Voltattorni, Carla Borri ^b   Perniola, Roberto ^c   Bertoldi, Mariarita ^b   Betterle, Corrado ^d   Mannelli, Massimo ^e   Giordano, Roberta ^f   De Bellis, Annamaria ^g   Tiberti, Claudio ^h   Laureti, Stefano ^a   Santeusanio, Fausto ^a   Falorni, Alberto ^a,i  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c VITO FAZZI HOSPITAL   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

^f UNIVERSITY OF TURIN   (Italy)

^g SECOND UNIVERSITY OF NAPLES   (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ Section of Internal Medicine and Endocrine and Metabolic Sciences   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; AUTOANTIBODY;

ADDISON DISEASE; ADOLESCENT; ADRENAL INSUFFICIENCY; ADULT; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; CHILD; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITOPE MAPPING; FEMALE; GRAVES DISEASE; HUMAN; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SWINE;

SUS;

EID: 33947504965     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2319     Document Type: Article

References (45)

1. Betterle C, Dal Pra C, Mantero F, Zanchetta R 2002 Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 23:327-364
2. Nomura K, Depura H, Saruta T 1994 Addison's disease in Japan: characteristics and changes revealed in a nationwide survey. Intern Med 33:602-606
3. Falorni A, Laureti S, Santeusanio F 2002 Autoantibodies in autoimmune polyendocrine syndrome type II. Endocrinol Metab Clin North Am 31:369-389
4. Falorni A, Laureti S 2000 Adrenal autoimmunity and correlation with adrenal dysfunction. Endocrinologist 10:145-154
5. Betterle C, Greggio NA, Volpato M 1998 Autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab 83:1049-1055
6. Heino M, Peterson P, Kudoh J, Shimizu N, Antonarakis SE, Scott HS, Krohn K 2001 APECED mutations in the autoimmune regulator (AIRE) gene. Hum Mutat 18:205-211
7. Robles DT, Fain PR, Gottlieb PA, Eisenbarth GS 2002 The genetics of autoimmune polyendocrine syndrome type II. Endocrinol Metab Clin North Am 31:353-368
8. Gambelunghe G, Kockum I, Bini V, De Giorni G, Celi F, Betterle C, Giordano R, Libè R, Falorni A 2005 Retrovirus-like long terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes mellitus and autoimmune Addison's disease. Diabetes 54:900-905
9. Ghaderi M, Gambelunghe G, Tortoioli C, Brozzetti A, Jatta K, Gharizadeh B, De Bellis A, Pecori Giraldi F, Terzolo M, Betterle C, Falorni A 2006 MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiency. J Clin Endocrinol Metab 91:4107-4111
10. Winqvist O, Karlsson FA, Kämpe O 1992 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 339:1559-1562
11. Bednarek J, Furmaniak J, Wedlock N, Kiso Y, Baumann-Antczak A, Fowler S, Krishnan H, Craft JA, Rees Smith B 1992 Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. FEBS Lett 309:51-55
12. Falorni A, Nikoshkov A, Laureti S, Grenbäck E, Hulting AL, Casacci G, Santeusanio F, Brunetti P, Luthman H, Lernmark Å 1995 High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J Clin Endocrinol Metab 80:2752-2755
13. Tanaka H, Perez MS, Powell M, Sanders JF, Sawicka J, Chen S, Prentice L, Asawa T, Betterle C, Volpato M, Rees Smith B, Furmaniak J 1997 Steroid 21-hydroxylase autoantibodies: measurements with a new immunoprecipitation assay. J Clin Endocrinol Metab 82:1440-1446
14. Falorni A, Laureti S, Nikoshkov A, Picchio ML, Hallengren B, Vandewalle CL, Gorus FK, Belgian Diabetes Registry, Tortoioli C, Luthman H, Brunetti P, Santeusanio F 1997 21-Hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease. Clin Exp Immunol 107:341-346
15. Perniola R, Falorni A, Clemente MG, Forini F, Accogli E, Lobreglio G 2000 Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Eur J Endocrinol 143:497-503
16. Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K 1992 Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase. Lancet 339:770-773
17. Chen S, Sawicka J, Betterle C, Powell M, Prentice L, Volpato M, Rees Smith B, Furmaniak J 1997 Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. J Clin Endocrinol Metab 81:1871-1876
18. do Carmo Silva R, Kater CE, Dib SA, Laureti S, Forini F, Cosentino A, Falorni A 2000 Autoantibodies against recombinant human steroidogenic enzyme 21-hydroxylase, side-chain cleavage and 17α-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III. Eur J Endocrinol 142:187-194
19. Tuomi T, Björses P, Falorni A, Partanen J, Perheentupa J, Lernmark Å, Miettinen A 1996 Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 81:1488-1494
20. Husebye ES, Gebre-Medhin G, Tuomi T, Perheentupa J, Landin-Olsson M, Gustafson J, Rorsman F, Kämpe O 1997 Autoantibodies against aromatic L-amino acid decarboxylase in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 82:147-150
21. Gebre-Medhin G, Husebye ES, Gustafson J, Winqvist O, Goksøyr A, Rorsman F, Kämpe O 1997 Cytochrome P450IA2 and aromatic L-amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I. FEBS Lett 412:439-445
22. Ekwall O, Sjöberg K, Mirakian R, Rorsman F, Kämpe O 1999 Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type I. Lancet 354:568
23. Ekwall O, Hedstrand H, Haavik J, Perheentupa J, Betterle C, Gustafsson J, Husebye E, Rorsman F, Kämpe O 2000 Pteridin-dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 85:2944-2950
24. Skoldberg F, Portela-Gomes GM, Grimelius L, Nilsson G, Perheentupa J, Betterle C, Husebye ES, Gustafsson J, Ronnblom A, Rorsman F, Kämpe O 2004 Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. J Clin Endocrinol Metab 88:1445-1452
25. Borri Voltattorni C, Minelli A, Dominici P 1983 Interaction of aromatic amino acids in D and L forms with 3,4-dihydroxyphenylalalnine decarboxylase from pig kidney. Biochemistry 22:2249-2254
26. Söderbergh A, Rorsman F, Halonen M, Ekwall O, Björses P, Kämpe O, Husebye ES 2000 Autoantibodies against aromatic L-amino acid decarboxylase identifies a subgroup of patients with Addison's disease. J Clin Endocrinol Metab 85:460-463
27. Dal Pra C, Chen S, Betterle C, Zanchetta R, McGrath V, Furmaniak J, Rees Smith B 2004 Autoantibodies to human tryptophan hydroxylase and aromatic L-amino acid decarboxylase. Eur J Endocrinol 150:313-321
28. Husebye ES, Bøe AS, Rorsman F, Kämpe O, Aakvaag A, Rygh T, Flatmark T, Haavik J 2000 Inhibition of aromatic L-amino acid decarboxylase activity by human autoantibodies. Clin Exp Immunol 120:420-423
29. Falorni A, Laureti S, De Bellis A, Zanchetta R, Tiberti C, Arnaldi G, Bini V, Beck-Peccoz P, Bizzarro A, Dotta F, Mantero F, Bellastella A, Betterle C, Santeusanio F 2004 Italian Addison Network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency. J Clin Endocrinol Metab 89:1598-1604
30. National Diabetes Data Group 1979 National Diabetes Data Group classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057
31. Moore PS, Dominici P, Borri Voltattorni C 1996 Cloning and expression of pig kidney dopa decarboxylase: comparison of the naturally occurring and recombinant enzymes. Biochem J 315:249-256
32. Maras B, Dominici P, Barra D, Bossa F, Voltattorni CB 1991 Pig kidney 3,4-dihydroxyphenylalanine (DOPA) decarboxylase. Primary structure and relationships to other amino acid decarboxylases. Eur J Biochem 201:385-391
33. 3H recombinant human ligands. J Immunol Methods 186:89-99
34. Bertoldi M, Moore PS, Maras B, Dominici P, Borri Voltattorni C 1996 Mechanism-based inactivation of DOPA decarboxylase by serotonin. J Biol Chem 271:23954-23959
35. Dominici P, Moore PS, Borri Voltattorni C 1993 Dissociation, unfolding and refolding trias of pig kidney 3,4-dihydroxyphenylalanine (DOPA) decarboxylase. Biochem J 295(Pt 2):493-500
36. Sherald AF, Sparrow JC, Wright TRF 1973 A spectrophotometric assay for Drosophila DOPA decarboxylase. Anal Biochem 56:300-305
37. Charteris A, John RA 1975 An investigation of the assay of dopamine using trinitrobenzenesulphonic acid. Anal Biochem 66:365-371
38. Cabrera Rode E, Sarmento L, Tiberti C, Molina G, Barrios J, Hernandez D, Diaz-Horta O, Di Mario U 2003 Type 1 diabetes islet associated antibodies in subjects infected by echovirus 16. Diabetologia 46:1348-1353
39. Betterle C, Scalici C, Precotto F, Pedini B, Moro L, Rigon F, Mantero F 1988 The natural history of adrenal function in autoimmune patients with adrenal autoantibodies. J Endocrinol 117:467-475
40. De Bellis A, Bizzarro A, Rossi R, Amoresano Paglionico V, Criscuolo T, Lombardi G, Bellastella A 1993 Remission of subclinical adrenocortical failure in subjects with adrenal autoantibodies. J Clin Endocrinol Metab 76:1002-1007
41. Rorsman F, Husebye ES, Winqvist O, Björk E, Karlsson FA, Kämpe O 1995 Aromatic L-amino acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a novel β-cell autoantigen. Proc Natl Acad Sci USA 92:8626-8629
42. Burkhard P, Dominici P, Borri Voltattorni C, Jansonius JN, Malashkevich VN 2001 Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase. Nat Struct Biol 8:963-967
43. Falorni A, Ackefors M, Carlberg C, Daniels T, Persson B, Robertson J, Lernmark Å 1996 Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia 39:1091-1098
44. Falorni A, Gambelunghe G, Forini F, Kassi G, Cosentino A, Candeloro P, Bolli GB, Brunetti P, Calcinaro F 2000 Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adultonset diabetes mellitus. J Clin Endocrinol Metab 85:309-316
45. Raju R, Foote J, Banga JP, Hall TR, Padoa CJ, Dalakas MC, Örtqvist E, Hampe CS 2005 Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients. J Immunol 175:7755-7762