21-hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease

Clinical and Experimental Immunology

Volumn 107, Issue 2, 1997, Pages 341-346

  Falorni, A ^a,b,e   Laureti, S ^a   Nikoshkov, A ^b   Picchio, M L ^a   Hallengren, B ^c   Vandewalle, C L ^d   Gorus, F K ^d   Tortoioli, C ^a   Luthman, H ^b   Brunetti, P ^a   Santeusanio, F ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e Dept Int Med Endocr Metab Sci ^*  (Italy)

Author keywords

Addison's disease; adrenal autoantibodies; polyendocrinopathy; radioimmunoassay; recombinant autoantigen

Indexed keywords

AUTOANTIBODY; RECOMBINANT PROTEIN; STEROID 21 MONOOXYGENASE;

ADDISON DISEASE; ADRENAL CORTEX; ADULT; AGED; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIAGNOSIS; ETIOLOGY; FEMALE; GRAVES DISEASE; HUMAN; IMMUNOFLUORESCENCE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 8044235834     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1997.262-ce1153.x     Document Type: Article

References (28)

1. Bottazzo GF. Todd I. Mirakian R. Belfiore A, Pujol-Borrell R. Organspecific autoimmunity: a 1986 overview. Immunol Rev 1996; 94:137-69.
2. Weetman AP. Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity. Baillieres' Clinical Endocrinol Metab 1995; 9:157-74.
3. Stuart Mason A, Meade TW, Lee JAM, Morris JN. Epidemiological and clinical picture of Addison's disease. Lancet 1968; 11:744-7.
4. Nerup J. Addison's disease-clinical studies. A report of 108 cases. Acta Endocrinol (Copenh) 1974; 76:127-41.
5. Ringstad J, Rodge S, Loland W, Rode L, Rapidly fatal Addison's disease: three case reports. J Intern Med 1991; 230:465-7.
6. Irvine WJ, Barnes EW. Addison's disease, ovarian failure, and hypoparathyroidism. Clin Endocrinol Metab 1975; 4:379-434.
7. Papadopoulos KI, Hallengren B. Polyglandular autoimmune syndrome Type II in patients with idiopathic Addison's disease. Acta Endocrinol (Copenh) 1990; 122:472-8.
8. Zelissen PMJ, Bast EJEG, Croughs RJM. Associated autoimmunity in Addison's disease. J Autoimmun 1995; 8:121-30.
9. Bottazzo GF, Doniach D. Polyendocrine autoimmunity: an extended concept. In: Volpe R, ed. Autoimmunity and endocrine disease. New York: Marcel/Dekker, 1985:375-403.
10. Winqvist O, Karlsson FA, Kämpe O. 21-hydroxylase. a major autoantigen in idiopathic Addison's disease. Lancet 1992; 339:1559-62.
11. Bednarek J, Furmaniak J, Wedlok N et al. Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. FEBS 1992; 309:51-55.
12. Falorni A, Nikoshkov A, Laureti S et al. High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J Clin Endocrinol Metab 1995; 80:2752-5.
13. Colls J, Betterle C, Volpato M, Prentice L, Smith BR, Furmaniak J. Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases. Clin Chem 1995; 41:375-80.
14. Chen S, Sawicka J, Betterle C, Powell M, Prentice L, Volpato M, Rees Smith B, Furmaniak J. Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. J Clin Endocrinol Metab 1996: 81:1871-6.
15. Hallengren B, Falorni A, Landin-Olsson M. Lernmark Å, Papadopoulos KI. Sundkvist G. Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients-at diagnosis and following treatment. J Intern Med 1996; 239:63-68.
16. Tuomi T, Björses P, Falorni A, Partanen J, Perheentupa J, Lernmark Å, Miettinen A, Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with APS 1 (autoimmune polyendocrine syndrome type 1), J Clin Endocrinol Metab 1996; 81: 1488-94.
17. Hagopian WA, Sanjeevi CB, Kockum I et al. Glutamate decarboxylase. insulin- and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 1995: 95:1505-11.
18. Vandewalle CL, Decraene T, Schuit FC et al. Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1 *0301-DQB1 *0302 haplotype at clinical onset of Type 1 (insulin-dependent) diabetes before age 10 but not at onset between age 10 and 40. Diabetologia 1993; 36:1155-62.
19. Vandewalle CL. Falorni A, Svanholm S, Lernmark Å Pipeleers DG, Gorus FK, Belgian Diabetes Registry. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. J Clin Endocrinol Metab 1995; 80:846-51.
20. Van Der Auwera B, Schuit F, Lyaruu I, Falorni A, Svanholm S, Vandewalle CL, Gorus FK, Belgian Diabetes Registry. Genetic-susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. J Clin Endocrinol Metab 1995;80:2567-73.
21. 3H recombinant human ligands. J Immunol Methods 1995; 186:89-99.
22. Betterle C, Scalici C, Presotto F, Pedini B, Moro L, Rigon F, Mantero F, The natural history of adrenal function in autoimmune patients with adrenal autoantibodies. J Endocrinol 1988; 117:467-75.
23. Falorni A, Grubin CE. Takei I et al. Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65.000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes. Autoimmunity 1994; 19:113-25.
24. Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K. Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17a-hydroxylase. Lancet 1992; 339:770-3.
25. Winqvist O, Gustaffson J, Rorsman F, Karlsson FA, Kämpe O. Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyglandular syndrome type I and Addison's disease. J Clin Invest 1993;92:2377-85.
26. Uibo R, Aavik E, Peterson P, Perheentupa J, Aranko S, Pelkonen A, Krohn KJ, Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular diseases types I and II and in Addison's disease. J Clin Endocrinol Metab 1994; 78:323-8.
27. Furmaniak J, Kominami S, Asawa T, Wedlock N, Colls J, Smith BR. Autoimmune Addison's disease: evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency. J Clin Endocrinol Metab 1494; 79:1517-21.
28. Boscaro M, Betterle C, Sonino N, Volpalo M, Paoletta A, Fallo F, Early adrenal hypofunction in patients with organ-specific autoantibodies and no clinical adrenal insufficiency. J Clin Endocrinol Metab 1994; 79:452-5.