Constitutive and induced activation of JAK/Stat pathway in leukemogenic and asymptomatic human T-cell lymphoptropic virus type 1 (HTLV-1) transformed rabbit cell lines

Immunology Letters

Volumn 109, Issue 2, 2007, Pages 113-119

  Samaan, Angela ^a   Mahana, Wahib ^a  

^a UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

Author keywords

HTLV I; Jak STAT; Phosphorylation; Rabbit model; Signal transduction; T cell activation; Virulence

Indexed keywords

ABELSON KINASE; ALPHA INTERFERON; INTERLEUKIN 10; JANUS KINASE; PROTEIN SERINE THREONINE KINASE; STAT PROTEIN; STAT5 PROTEIN; VAV PROTEIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMOGENESIS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; SUPERNATANT; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; VIRUS VIRULENCE;

ANIMALS; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; ENZYME ACTIVATION; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-10; INTERLEUKIN-2; JANUS KINASES; PHOSPHORYLATION; RABBITS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; T-LYMPHOCYTES; TRANSFECTION; TYK2 KINASE;

EID: 33947390865     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.01.008     Document Type: Article

References (53)

1. Poiesz B.J., Ruscetti F.W., Gazdar A.F., Bunn P.A., Mina J.D., and Gallo R.C. Detection and isolation of type C retrovirus particles from fresh and cultured lyphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77 (1980) 7415-7419
2. Seto A., Kawanishi M., Matsuda S., Ogawa K., Eguchi T., and Miyoshi I. Induction of preleukemic stage of adult T cell leukemia like disease in rabbits. Jpn J Cancer Res 78 (1987) 1150-1155
3. + cells by in vitro transformation with human T lymphotropic virus type I. J Exp Med 178 (1993) 1337-1345
4. Simpson R.M., Zhao T.M., Hubbard B.S., Sawasdikosol S., and Kindt T.J. Experimental acute adult T cell leukemia. lymphoma is associated with thymic atrophy in human T cell leukemia virus type I infection. Lab Invest 74 (1996) 696-710
5. Zhao T.M., Robinson M.A., Sawasdikosol S., Simpson R.M., and Kindt T.J. Variation in HTLV-1 sequences from rabbit cell lines with diverse in vivo effects. Virology 195 (1993) 271-274
6. Leno M., Simpson R.M., Bowers F.S., and Kindt T.J. Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and vitro lymphocyte apoptosis. J Exp Med 181 (1995) 1575-1580
7. Zhao T.M., Robinson M.A., Bowers F.S., and Kindt T.J. Characterization of an infectious molecular clone of human T-cell leukemia virus type I. J Virol 69 (1995) 2024-2030
8. Velazques L., Fellous M., Stark G.R., and Pellegrini S. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 24 (1992) 313-322
9. Ihle J.N., Witthuhn B.A., Quelle F.W., Yamamoto K., and Silvennoinen O. Signaling through the hematopoietic cytokine receptors. Ann Rev Immunol 13 (1995) 369-398
10. Weber-Nordt R.M., Mertelsmann R., and Finke J. The JAK-STAT pathway: signal transduction involved in proliferation, differentiation and transformation. Leuk Lymphoma 28 (1998) 459-467
11. Migone T.S., Lin J.X., Ceresto A., Mulloy J.C., O'Shea J., Franchini G., et al. Constitutively activated Jak-STAT pathway in T cell transformed with HTLV-1. Science 269 (1995) 79-81
12. Xu X., Kang S.H., Heidenreich O., Okerholm M., O'She J., and Nerenberg M.I. Constitutive activation of different Jak tyrosine kinases in human T cell leukeima virus type 1(HTLV-1) Tax protein or virus transformed cells. J Clin Invest 96 (1995) 1548-1555
13. Takemoto S., Mulloy J.C., Cereseto A., Migone T.S., Patel B.K., Matsuoka M., et al. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of Jak/STAT proteins. Proc Natl Acad Sci USA 94 (1997) 13897-13902
14. Benekli M., Baer M.R., Baumann H., and Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 10 (2003) 2940-2954
15. Malmgaard L. Induction and regulation of IFNs during viral infections. J. Interferon Cytokine Res 24 (2004) 439-454
16. Haura E.B., Turkson J., and Jove R. Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2 (2005) 315-324
17. Best S.M., Morris K.L., Shannon J.G., Robertson S.J., Mitzel D.N., Park G.S., et al. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. J Virol 79 (2005) 12828-12839
18. Waris G., Turkson J., Hassanein T., and Siddiqui A. Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J Virol 79 (2005) 1569-1580
19. Mahana W., Zhao T.M., Teller R., Robinson M.A., and Kindt T.J. Genes in the pX region of human T cell leukemia virus-I influence vav phosphorylation in T cells. Proc Natl Acad Sci USA 95 (1998) 1782-1787
20. Samaan A., Haddad E., and Mahana W. Constitutive and differential phosphorylation of Cbl in HTLV-I transformed cell lines. Int J Virol 2 (2006) 39-49
21. Daniel M.D., Melendez L.V., Hunt R.D., King N.W., Anver M., Fraser C.E.H., et al. Herpsvirus-saimiri. VII. Induction of malignant lymphoma in New Zealand white rabbit. J Natl Cancer Inst 53 (1974) 1803-1807
22. Zhao T.M., Robinson M.A., Bowers F.S., and Kindt T.J. Invectivity of chimeric human T-cell leukemia virus type-1 molecular clones assessed by naked DNA inoculation. Proc Natl Acad Sci USA 93 (1996) 6653-6658
23. Al-Shami A., Mahana W.H., and Naccache P. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. J Biol Chem 273 (1998) 1058-1063
24. Zhang D., Sun M., Samols D., and Kushner I. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J Biol Chem 271 (1996) 9503-9509
25. Beadling C., Guschin D., Witthuhn B.A., Ihle J.N.M., Kerr I., and Cantrell D.A. Activation of Jak kinases and stat proteins by interleukine-2 and interferon α, but not T-cell antigen receptor, in human T lymphocytes. EMBO J 13 (1994) 5605-5615
26. Kindt TJ, Zhao TM, Simpson RM, Hague BF, Robinson MA, Mahana W. Role of differences in HTLV-I pX region protein on protein phosphorylation and virus production by infected rabbit T cells. In: Semmes, OJ, Hammarskjold, editors. Molecular pathogenesis of HTLV-1: A current perspective. M.J. Arlington; 1999. p. 105-14.
27. Welte T., Leitenberg D., Dittel B.N., Al-Ramadi B.K., Xie B., Chin Y.E., et al. Stat5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 283 (1999) 222-225
28. Secrist J.P., Burns L.A., Karnitz L., Koretzky G.A., and Abraham R.T. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem 15 (1993) 5886-5893
29. Ressler S., Connor L.M., and Marriott S.J. Cellular transformation by human T cell leukemia virus type I. FEMS Microbiol Lett 140 (1996) 99-109
30. O'Shea J.J. STATs, cytokine signal transduction, and immunoregulation: are we there yet?. Cell 7 (1997) 1-11
31. Schindler C., and Darnell J.E. Transcriptional responses to polypeptide ligands: the Jak-Stat pathway. Annu Rev Biochem 64 (1995) 621-651
32. Darnell J.E., Kerr I.M., and Stark G.R. Jak-Stat pathway and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994) 1415-1421
33. Gouilleux-Gruart V., Debierre-Grockiego F., Gouilleux F., Capiod J.C., Claisse J.F., Delobel J., et al. Activated Stat related transcription factors in acute leukemia. Leuk Lymphoma 28 (1997) 83-88
34. Chai S.K., Nichols G.L., and Rothman P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol 159 (1997) 4720-4846
35. Watson C.J., and Miller W.R. Elevated levels of members of Stat family of transcription factors in breast carcinoma nuclear extracts. Br J Cancer 71 (1995) 840-845
36. Weber-Nordt R.M., Egen C., Wehinger J., Ludwig W., Gouilleux-Gruart V., Metrelsmann R., et al. Constitutive activation of Stat proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell line. Blood 88 (1996) 809-816
37. Yu C.L., Meyer D.J., Campbll G.S., Larner A.C., Carter-Su C., Schwartz J., et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269 (1995) 81-83
38. Yu C.L., Jove R., and Burakoff S.J. Constitutive activation of the Jaunus kinase pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J Immunol 159 (1997) 5206-5210
39. Zong C., Yan R., August A., Darnell J.E., and Hanafusa H. Unique signal transduction of Eyk: constitutive stimulation of the Jak-Stat pathway by an oncogenic receptor-type tyrosine kinase. EMBO J 15 (1996) 4515-4525
40. Danial N.N., Pernis A., and Rothman P.B. Jak-STAT signaling induced by the v-abl oncogene. Science 269 (1995) 1875-1877
41. Meydan N., Grunberger T., Dadi H., and Roifman C.M. Inhibition of acute lymphoblastic leukemia by a Jak2 inhibitor. Nature 379 (1996) 645-648
42. Finbloom D.S., and Winstock K.D. IL-10 induces tyrosine phosphorylationof tyk2 and jak1 and differential assembly of Stat1a and Stat3 complex in human T cells and monocytes. J Immunol 155 (1995) 1079-1090
43. Richter M.F., Duménil G., Uzé G., Fellous M., and Pellegrini S. Specific contribution of Tyk2 JH region to the binding and the expression of the interferon α/β receptor component IFNAR1. J Biol Chem 273 (1998) 24723-24729
44. Bealing C., Johnson K.W., and Smith K.A. Isolation of interleukin2-induced immediate-early genes. Proc Natl Acad Sci USA 90 (1993) 2719-2723
45. Boulton T.G., Stahi N.S., and Yancopoulos G.D. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin6/oncostatinM family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 269 (1994) 11648-11655
46. Wehinger J., Gouilleux F., Groner B., Finke J., and Mertelsmann R. Weber-Nordt MR. IL-10 induces DNA binding activity of three Stat proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett 394 (1996) 365-370
47. Weber-Nordt R.M., Riley J.K., Greenlund A.C., Moore K.W., Darnell J.E., and Schreiber R.D. Stat3 recruitment by two distinct ligand-induced tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. J Biol Chem 271 (1996) 27954-27961
48. Lai C.F., Ripperger J., Morella K.K., Jurlander J., Hawley T.S., Carson W.E., et al. Receptors for IL-10 and Il-6-type cytokines use similar mechanisms for inducing transcription through IL-6 response elements. J Biol Chem 271 (1996) 13968-13975
49. Zhang X., blenis J., Li H.-C., Schindler C., and Chen-Kiang S. Requirement of serine phosphorylation for formation of Stat-promoter complexs. Science 267 (1995) 1990-1994
50. Chung J., Uchida E., Grammer T.C., and Blenis J. Stat3 serine phosphorylation by ERK-dependent and-independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 17 (1997) 6508-6516
51. Ram P.A., Park S.H., Choi H.K., and Waxman D.J. Growth hormone activation of Stat1, Stat3, and Stat5 in rat liver: differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J Biol Chem 271 (1996) 5929-5940
52. Liang W., Hague B., Zhao T., and Kindt T.J. HTLV-1 cell lines differ in constitutively activated signaling pathways that can be altered by cytokine exposure. Virology 290 (2001) 91-98
53. Yu H., and Jove R. The stats of cancer-new molecular targets come of age. Nat Rev Cancer 4 (2004) 97-105