Effect of prenatal administration of NSAIDs on the immune response in juvenile and adult rats

Toxicology

Volumn 232, Issue 3, 2007, Pages 257-267

  Kushima, Kiyoshi ^a,b   Oda, Keiko ^a   Sakuma, Shozo ^a   Furusawa, Shuichi ^b   Fujiwara, Michio ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Developmental immunotoxicity; Flow cytometry; Non steroidal anti inflammatory drugs; Rat; T dependent antibody response

Indexed keywords

ACETYLSALICYLIC ACID; CD3 ANTIGEN; CD45RA ANTIGEN; DICLOFENAC; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INDOMETACIN; METHYLCELLULOSE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; AQUEOUS SOLUTION; ARTICLE; BIRTH; CELL COUNT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GESTATIONAL AGE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPHENOTYPING; MALE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; SPLEEN CELL; SPLEEN WEIGHT; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODY FORMATION; ASPIRIN; DICLOFENAC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEMOCYANIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOPHENOTYPING; INDOMETHACIN; LYMPHOCYTES; MALE; MATERNAL EXPOSURE; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN;

RATTUS;

EID: 33947383755     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.01.012     Document Type: Article

References (40)

1. Aledsandrova G.M., Rozhkova V.N., and Borisova L.N. Comparative characteristics of the immunotropic activity of sodium diclofenac, indomethacin and sodium salicylate. Farmakol. Toksikol. 44 (1981) 450-453 Russian
2. Baba T., Nagahama M., Akiyama N., and Miki T. Experimental production of malformation due to acetyl salicylate and phenyl salicylate in rats. Osaka City Med. J. 12 (1966) 23-29
3. Barasoain I., Rojo J.M., and Portoles A. "In Vivo" effects of acetylsalicylic acid and two ether derived compounds on primary immune response and lymphoblastic transformation. Immunopharmacology 2 (1980) 293-300
4. Barrow P.C., and Ravel G. Immune assessments in developmental and juvenile toxicity: practical considerations for the regulatory safety testing of pharmaceuticals. Regul. Toxicol. Pharmacol. 43 (2005) 35-44
5. Barrow P.C., Horand F., and Ravel G. Developmental immunotoxicity investigations in the SD rat following pre- and post-natal exposure to cyclosporin. Birth Defects Res. B 77 (2006) 430-437
6. Boorman G.A., Luster M.I., Dean J.H., and Luebke R.W. Effect of indomethacin on the bone marrow and immune system of the mouse. J. Clin. Lab. Immunol. 7 (1982) 119-126
7. Bukowski B., McKay L., Shi S.-Q., Saade G.R., and Garfield R.E. The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. Am. J. Obstet. Gynecol. 185 (2001) 959-965
8. Buse E., Habermann G., Osterburg I., Korte R., and Weinbauer G.F. Reproductive/developmental toxicity and immunotoxicity assessment in the nonhuman primate model. Toxicology 185 (2003) 221-227
9. Chapin R.E. The use of the rat in developmental immunotoxicology studies. Hum. Exp. Toxicol. 21 (2002) 521-523
10. Dietert R.R., Lee J.-E., Hussain I., and Piepenbrink K. Developmental immunotoxicology of lead. Toxicol. Appl. Pharmacol. 198 (2004) 86-94
11. Ebersole J.L., Smith D.J., and Taubman M.A. Secretory immune responses in aging rats. Immunogloblin levels. Immunology 56 (1985) 345-350
12. Exon J.H., and Talcott P.A. Enzyme-linked immunosorbent assay (ELISA) for detection of specific IgG antibody in rats. In: Burleson G.R., Dean J.H., and Munson A.E. (Eds). Methods in Immunotoxicology vol. 1 (1995), Wiley-Liss, New York pp. 109-124
13. Gore E.R., Gower J., Kurale E., Sui J.-L., Bynum J., Ennulat D., and Herzyk D.J. Primary antibody response to keyhole limpet hemocyanin in rat as a model for immunotoxicity evaluation. Toxicology 197 (2004) 23-35
14. Grohmann P.H., Porzsolt F., Quirt I., Miller R.G., and Phillips R.A. Stimulation of human NK activity by cultured cells. II. Ingestion of aspirin by blood donors suppresses induced NK activity. Clin. Exp. Immunol. 44 (1981) 611-614
15. Helleberg L. Clinical pharmacokinetics of indomethacin. Clin. Pharmacokinet. 6 (1981) 245-252
16. Hockertz S., Schettler T., and Rogalla K. Effect of acetylsalicylic acid, ascorbate and ibuprofen on the macrophage system. Arzneimittelforschung 42 (1992) 1062-1068
17. Holladay S.D., and Blaylock B.L. The mouse as a model for developmental immunotoxicology. Hum. Exp. Toxicol. 21 (2002) 525-531
18. Holsapple M.P., West L.J., and Landreth K.S. Species comparison of anatomical and functional immune system development. Birth Defects Res. B 68 (2003) 321-334
19. Holsapple M.P. Developmental immunotoxicity testing: a review. Toxicology 185 (2003) 193-203
20. Holsapple M.P., Burns-Naas L.A., Hastings K.L., Ladics G.S., Lavin A.L., Makris S.L., Yang Y., and Luster M.I. A proposed testing framework for developmental immunotoxicity. Toxicol. Sci. 83 (2005) 18-24
21. Hussain I., Piepenbrink M.S., Fitch K.J., Marsh J.A., and Dietert R.R. Developmental immunotoxicity of cyclosporin-A in rats: age-associated differential effects. Toxicology 206 (2005) 273-284
22. Jaramillo A., Bhattacherjee P., Sonnenfeld G., and Paterson C.A. Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation. Curr. Eye Res. 11 (1992) 571-579
23. Luebke R.W., Chen D.H., Dietert R., Yang Y., King M., and Luster M.I. The comparative immunotoxicity of five selected compounds following developmental or adult exposure. J. Toxicol. Environ. Health Part B 9 (2006) 1-26
24. Moed H., Stoof T.J., Boorsma D.M., Von Blomberg B.M.E., Gibbs S., Bruynzeel D.P., Scheper R.J., and Rustemeyer T. Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 cell profiles. Clin. Exp. Allergy 34 (2004) 1868-1875
25. Moise Jr. K.J., Ou C.N., Kirshon B., Cano L.E., Rognerud C., and Carpenter Jr. R.J. Placental transfer of indomethacin in the human pregnancy. Am. J. Obstet. Gynecol. 162 (1990) 549-554
26. Morozova E.V. Structure of the mesenteric lymph nodes in fetuses and offspring of white rats under the effect of indomethacin on the mother-fetus system. Arkh. Anat. Gistol. Embriol. 96 (1989) 48-55
27. Morozova E.V. Structure of the rat lymphoid organs after prenatal exposure to indomethacin during antigenic stimulation. Morfologiia 113 (1998) 76-80
28. Mukherjee A., Hale V.G., Borga O., and Stein R. Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats. Inflamm. Res. 45 (1996) 531-540
29. Pedersen B.K., Oxholm P., and Klarlund K. Characterization of the in vivo and in vitro effects of indomethacin on human natural killer cell activity. Allergy 41 (1986) 532-536
30. Pillet S., Rooney A.A., Bouquegneau J.M., Cyr D.G., and Fournier M. Sex-specific effect of neonatal exposures to low levels of cadmium through maternal milk on development and immune functions of juvenile and adult rats. Toxicology 209 (2005) 289-301
31. Porzsolt F., and Wolf W. Modulation of natural killer activity by aspirin. I. In vitro effect of aspirin. J. Interferon Res. 3 (1983) 11-17
32. Rodoriguez A.B., Barriga C., and De la Fuente M. Effects of acetylsalicylic acid on the phagocytic function of human polymorphonuclear leukocytes in vitro. Gen. Pharmacol. 20 (1989) 151-155
33. Rojo J.M., Barasoain I., and Portoles A. Further studies on the immunosuppressive effects of indomethacin. Int. J. Clin. Pharmacol. Ther. Toxicol. 19 (1981) 220-222
34. Rothkotter H.J., Sowa E., and Pabst R. The pig as a model of developmental immunology. Hum. Exp. Toxicol. 21 (2002) 533-536
35. Santoni G., Cantalamessa F., Mazzucca L., Romagnoli S., and Piccoli M. Prenatal exposure to cypermethrin modulates rat NK cell cytotoxic function. Toxicology 120 (1997) 231-242
36. Shafiq N., Malhotra S., and Pandhi P. Comparison of nonselective cyclo-oxygenase (COX) inhibitor and selective COX-2 inhibitors on preimplantation loss, postimplantation loss and duration of gestation and experimental study. Contraception 69 (2004) 71-75
37. Tanaka S., Barbour S.E., Best A.M., Schenkein H.A., and Tew J.G. Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma. J. Periodontol. 74 (2003) 771-779
38. Traeger V.A., Noshel H., and Zaumseil J. Pharmacokinetics of indomethacin in pregnant and parturient women and in their newborn infants. Zentralbl. Gynakol. 95 (1973) 635-641 article in German
39. Voth R., Chmielarczyk W., Storch E., and Kirchner H. Induction of natural killer cell activity in mice by injection of indomethacin. Nat. Immun. Cell Growth Regul. 5 (1986) 317-324
40. Yamaki K., Uchida H., Harada Y., Yanagisawa R., Takano H., Hayashi H., Mori Y., and Yoshino S. Effect of the nonsteroidal anti-inflammatory drug indomethacin on Th1 and Th2 immune response in mice. J. Pharm. Sci. 92 (2002) 1723-1729