Primary antibody response to keyhole limpet hemocyanin in rat as a model for immunotoxicity evaluation

Toxicology

Volumn 197, Issue 1, 2004, Pages 23-35

  Gore, Elizabeth R ^a   Gower, Jill ^a   Kurali, Edit ^a   Sui, Jui Lan ^a   Bynum, Jane ^a   Ennulat, Daniela ^a   Herzyk, Danuta J ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

ELISA; Immunosuppression; Immunotoxicity; KLH antibodies; Rat

Indexed keywords

ANTIBODY; AZATHIOPRINE; CYCLOSPORIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; IMMUNOSUPPRESSIVE AGENT; KEYHOLE LIMPET HEMOCYANIN; PREDNISOLONE; T LYMPHOCYTE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG TOLERABILITY; EVALUATION; FEMALE; FOOT PAD; GERMINAL CENTER; HEMATOLOGY; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; STANDARDIZATION; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS;

ANIMALS; ANTIBODY FORMATION; ANTIGENS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOOT; HEMOCYANIN; HINDLIMB; HYPERPLASIA; IMMUNITY, CELLULAR; IMMUNOCOMPROMISED HOST; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS; MALE; MODELS, ANIMAL; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY TRACT INFECTIONS;

ANIMALIA;

EID: 1542315575     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2003.12.003     Document Type: Article

References (26)

1. Abbas, A.K., Lichtman, A.H., Pober, J.S. (Eds.), 2000. Effector mechanisms of humoral immunity. Cellular and Molecular Immunology, 4th ed. Saunders, Philadelphia, pp. 309-334.
2. Crevel R.W.R., Buckley P., Robinson J.A., Sanders I.J. Immunotoxicological assessment of cyclosporin A by conventional pathological techniques and immune function testing in the rat. Hum. Exp. Toxicol. 16:1997;79-88.
3. Dean J.H., Luster M.I., Boorman G.A., Lauer L.A.D., Leubke R.W., Lawson L. Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F1 mice. Clin. Exp. Immunol. 52:1983;199-206.
4. Dean J.H., Hincks J.R., Remandet B. Immunotoxicology assessment in the pharmaceutical industry. Toxicol. Lett. 102-103:1998;247-255.
5. Dean J.H., Remandet B. Integration of immunotoxicology evaluation in drug development. Drug Inform. J. 31:1997;1347-1356.
6. Elwell M.R., Mahler J.F., Rao G.N. Have you seen this? Inflammatory lesions in the lungs of rats. Toxicol. Pathol. 25:1997;529-531.
7. EMEA, 2000. Note for guidance on repeated dose toxicity. CPMP/SWP/1042/99. http://www.emea.eu.int/.
8. Farrar P., LaRegina M. Diagnostic exercise: interstitial pneumonia in viral and mycoplasma antibody-free Sprague Dawley rats. ACLAD Newslett. 18:1997;5-9.
9. FDA, 2002. Guidance for industry: immunotoxicology evaluation of investigational new drugs. http://www.fda.gov/cder/guidance/.
10. Johnson C.W., Williams W.C., Copeland C.B., Devito M.J., Smialowicz R.J. Sensitivity of the SRBC PFC assay versus ELISA for the detection of immunosuppression by TCDD and TCDD-like congeners. Toxicology. 156:2000;1-11.
11. Ladics G.S., Smith C., Heaps K., Elliot G.S., Slone T.W., Loveless S.E. Possible incorporation of an immunotoxicologic functional assay for assessing humoral immunity for hazard identification purposes in rats on standard toxicology studies. Toxicology. 96:1995;225-238.
12. Ladics G.S., Smith C., Elliot G.S., Slone T.W., Loveless S.E. Further evaluation of the incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats in a standard toxicology study. Toxicology. 126:1998;147-152.
13. Littell, R.C., Milliken, G.A., Stroup, W.W., Wolfinger, R.D., 1996. SAS System for MIXED Models. SAS Institute Inc., Cary, NC.
14. Matsuura M., Imayoshi T., Okumoto T. Int. J. Immunopharmacol. 22(4):2000;323-331.
15. Milliken, G.A., Johnson, D.E., 1992. Analysis of messy data, vol. I, Designed Experiment. Chapman & Hall, New York.
16. Richter-Reichhelm H.-B., Schulte A.E. Results of a cyclosporin: a ringstudy. Toxicology. 129:1998;91-94.
17. Riley L., Purdy J., Dudds J., Franklin C., Besch-Williford C., Hook R. Jr., Wagner J. Idiopathic lesions in rats: search foran etiologic agent. Contemp. Top. Lab. Anim. Sci. 36:1997;46.
18. SAS, 1997. SAS/STAT Software: Changes and Enhancements through Release 6.12. SAS Institute Inc., Cary, NC.
19. Sovcikova A., Tulinska J., Kubova J. Effect of cyclosporin A in Lewis rats in vivo and HeLa cells in vitro. J. Appl. Toxicol. 22:2002;153-160.
20. Su J.-L., Stimpson S., Edwards E.D., Van Arnold J., Burgess S., Lin P. Neutralizing IGF-1 monoclonal antibody with cross-species reactivity. Hybridoma. 16:1997;513-518.
21. Temple L., Kawabata T.T., Munson W.E., White K.L. Jr. Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamide. Fundam. Appl. Toxicol. 21:1993;412-419.
22. The ICICIS Group Investigators, 1998. Report validation study of assessment of direct immunotoxicity in the rat. Toxicology 125, 13-201.
23. Van Loveren H., Vos J.G., De Waal E.J. Testing immunotoxicity of chemicals as a guide for testing pharmaceuticals. Drug Inf. J. 30:1996;275-279.
24. Van Loveren, H., Vos, J.G., 1989 Immunotoxicological considerations: a practical approach to immunotoxicity testing in the rat. In: Taylor, Francis (Eds.), Advances in Applied Toxicology, pp. 143-165.
25. Vos, J.G., 1980. Immunotoxicity assessment: screening and function studies. Arch. Toxicol. (Suppl. 4), 95-108.
26. Wilson S.D., Munson A.E., Meade B.J. Assessment of the functional integrity of the humoral immune response the plaque forming cell assay and the enzyme linked immunosorbent assay. Methods. 19:1999;3-7.