Cholesteryl Ester-Transfer Protein (CETP) polymorphism and the association of acute coronary syndromes by obesity status in Greek subjects: The CARDIO2000-Gene study

Human Heredity

Volumn 63, Issue 3-4, 2007, Pages 155-161

  Dedoussis, George V ^a   Panagiotakos, Demosthenes B ^a   Louizou, Eirini ^a   Mantoglou, Ioulia ^a   Chrysohoou, Christina ^b   Lamnisou, Klea ^c   Pitsavos, Christos ^b   Stefanadis, Christodoulos ^b  

^a HAROKOPIO UNIVERSITY   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Association study; Cardiovascular diseases; Case control; CETP; Obesity

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN;

ACUTE CORONARY SYNDROME; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HOSPITAL PATIENT; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION SYSTEM; METABOLIC REGULATION; OBESITY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ACUTE DISEASE; AGED; ANGINA, UNSTABLE; CHOLESTEROL ESTER TRANSFER PROTEINS; FEMALE; GENE FREQUENCY; GENOTYPE; GREECE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; OBESITY; POLYMORPHISM, GENETIC; SYNDROME;

EID: 33947359467     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000099827     Document Type: Article

References (34)

1. Yen FT, Deckelbaum RJ, Mann CJ, Marcel YL, Milne RW, Tall AR: Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody: Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma. J Clin Invest 1989;83:2018-2024.
2. Hannuksela ML, Liinamaa MJ, Kesaniemi YA, Savolainen MJ: Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers. Atherosclerosis 1994;110:35-44.
3. Bhatnagar D, Durrington PN, Channon KM, Prais H, Mackness MI: Increased transfer of cholesteryl esters from high density lipoproteins to low density and very low density lipoproteins in patients with angiographic evidence of coronary artery disease. Atherosclerosis 1993;98:25-32.
4. Heilbronn LK, Noakes M, Clifton PM: Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women. Atherosclerosis 2002;162:419-424.
5. Drayna D, Lawn R: Multiple RFLPs at the human cholesteryl ester transfer protein (CETP) locus. Nucl Acids Res 1987;15:4698.
6. Thompson JF, Lira ME, Durham LK, Clark RW, Bamberger MJ, Milos PM: Polymorphisms in the CETP gene and association with CETP mass and HDL levels. Atherosclerosis 2003;167:195-204.
7. Klerkx AH, Tanck MW, Kastelein JJ, Molhuizen HO, Jukema JW, Zwinderman AH, Kuivenhoven JA: Haplotype analysis of the CETP gene: Not TaqIB, but the closely linked -629C -> A polymorphism and a novel promoter variant are independently associated with CETP concentration. Hum Mol Genet 2003;12:111-123.
8. Lu H, Inazu A, Moriyama Y, Higashikata T, Kawashiri MA, Yu W, Huang Z, Okamura T, Mabuchi H: Haplotype analyses of cholesteryl ester transfer protein gene promoter: A clue to an unsolved mystery of TaqIB polymorphism. J Mol Med 2003;81:246-255.
9. Brousseau ME, O'Connor JJ Jr, Ordovas JM, Collins D, Otvos JD, Massov T, McNamara JR, Rubins HB, Robins SJ, Schaefer EJ: Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial. Arterioscler Thromb Vasc Biol 2002;22:1148-1154.
10. Arai T, Yamashita S, Hirano K, Sakai N, Kotani K, Fujioka S, Nozaki S, Keno Y, Yamane M, Shinohara E, et al: Increased plasma cholesteryl ester transfer protein in obese subjects. A possible mechanism for the reduction of serum HDL cholesterol levels in obesity. Arterioscler Thromb 1994;14:1129-1136.
11. Freeman DJ, Samani NJ, Wilson V, McMahon AD, Braund PS, Cheng S, Caslake MJ, Packard CJ, Gaffney D: A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. Eur Heart J 2003;24:1833-1842.
12. Fumeron F, Betoulle D, Luc G, Behague I, Ricard S, Poirier O, Jemaa R, Evans A, Arveiler D, Marques-Vidal P, et al: Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction. J Clin Invest 1995;963:1664-1671.
13. Panagiotakos DB, Pitsavos C, Polychronopoulos E, Chrysohoou C, Zampelas A, Trichopoulou A: Can a Mediterranean diet moderate the development and clinical progression of coronary heart disease? A systematic review. Med Sci Monit 2004;10:193-198.
14. Dedoussis GV, Panagiotakos DB, Vidra NV, Louizou E, Chrysohoou C, Germanos A, Mantas Y, Tokmakidis S, Pitsavos C, Stefanadis C: Association between TNF-alpha - 308G>A polymorphism and the development of acute coronary syndromes in Greek subjects: The CARDIO2000-GENE Study. Genet Med 2005;7:411-416.
15. Povey S, Lovering R, Bruford E, Wright M, Lush M, Wain H: The HUGO Gene Nomenclature Committee (HGNC). Hum Genet 2001;109:678-680.
16. Braunwald E: Heart Disease. 5th Ed. London, WB Saunders Company, USA, 1997:1331-1332.
17. Mitchell RJ, Earl L, Bray P, Fripp YJ, Williams J: DNA polymorphisms at the lipoprotein lipase gene and their association with quantitative variation in plasma high-density lipoproteins and triacylglycerides. Hum Biol 1994;66:383-97.
18. Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, et al: Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995;273:402-407.
19. Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, et al: Mediterranean diet pyramid: A cultural model for healthy eating. Am J Clin Nutr 1995;61:1402S-1406S.
20. Radloff LS: The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385-401.
21. Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C, Toutouzas P: Risk stratification of coronary heart disease in Greece: Final results from the CARDIO2000 Epidemiological Study. Prev Med 2002:35:548-556.
22. Eisenstein EL, McGuire DK, Bhapkar MV, Kristinsson A, Hochman JS, Kong DF, Califf RM, Van de Werf F, Yancy WS Jr, Newby LK: Elevated body mass index and intermediate-term clinical outcomes after acute coronary syndromes. Am J Med 2005;118:981-990.
23. Eckel RH: Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1997;96:3248-3250.
24. Eckel RH, Barouch WW, Ershow AG: Report of the National Heart, Lung, and Blood Institute - National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the Pathophysiology of Obesity-Associated Cardiovascular Disease. Circulation 2002;105:2923-2928.
25. Lopez-Jimenez F, Jacobsen SJ, Reeder GS, Weston SA, Killian JM, Meverden R, Roger VL: Prevalence of risk factors for coronary disease in myocardial infarction in the community. J Am Coll Cardiol 2003;41:291-A.
26. Panagiotakos DB, Pitsavos C, Chrysohoou C, Risvas G, Kontogianni MD, Zampelas A, Stefanadis C: Epidemiology of overweight and obesity in a Greek adult population: the ATTICA Study. Obes Res 2004;12:1914-1920.
27. Wolk R, Berger P, Lennon RJ, Brilakis ES, Somers VK: Body mass index: A risk factor for unstable angina and myocardial infarction in patients with angiographically confirmed coronary artery disease. Circulation 2003;108:2206-2211.
28. Lakka HM, Lakka TA, Tuomilehto J, Salonen JT: Abdominal obesity is associated with increased risk of acute coronary events in men. Eur Heart J 2002;23:706-713.
29. Freeman DJ, Griffin BA, Holmes AP, Lindsay GM, Gaffney D, Packard CJ, Shepherd J: Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors. Associations between the TaqI B RFLP in the CETP gene and smoking and obesity. Arterioscler Thromb 1994:14:336-344.
30. Vohl MC, Lamarche B, Pascot A, Leroux G, Prud'homme D, Bouchard C, Nadeau A, Despres JP: Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome. Int J Obes Relat Metab Disord 1999;23:918-925.
31. Corbex M, Poirier O, Fumeron F, Betoulle D, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L, Cambien F: Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene-environment interaction. Genet Epidemiol 2000;19:64-80.
32. Dachet C, Poirier O, Cambien F, Chapman J, Rouis M: New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol levels: Role of Sp1/Sp3 in transcriptional regulation. Arterioscler Thromb Vasc Biol 2000;20:507-515.
33. Blankenberg S, Rupprecht HJ, Bickel C, Jiang XC, Poirier O, Lackner KJ, Meyer J, Cambien F, Tiret L: AtheroGene Investigators: Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease. J Am Coll Cardiol 2003;41:1983-1989.
34. Carlquist JF, Muhlestein JB, Horne BD, Hart NI, Bair TL, Molhuizen HO, Anderson JL: The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease. Am Heart J 2003;146:1007-1014.