-
1
-
-
0027466057
-
The effect of anticancer drug sequence in experimental combination chemotherapy
-
Adel AL, Dorr RT, Liddil JD (1993) The effect of anticancer drug sequence in experimental combination chemotherapy. Cancer Investig 11:15
-
(1993)
Cancer Investig
, vol.11
, pp. 15
-
-
Adel, A.L.1
Dorr, R.T.2
Liddil, J.D.3
-
2
-
-
0024520963
-
Characterization of cisplatin resistance in COLO 316 human ovarian carcinoma cells
-
Andrews PA, Murphy MP, Howell SB (1989) Characterization of cisplatin resistance in COLO 316 human ovarian carcinoma cells. Eur J Cancer Clin Oncol 25:619
-
(1989)
Eur J Cancer Clin Oncol
, vol.25
, pp. 619
-
-
Andrews, P.A.1
Murphy, M.P.2
Howell, S.B.3
-
3
-
-
0021127473
-
Glutathione metabolism as a determinant of therapeutic efficacy: A review
-
Arrick BA, Nathan CF (1984) Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res 44:4224
-
(1984)
Cancer Res
, vol.44
, pp. 4224
-
-
Arrick, B.A.1
Nathan, C.F.2
-
4
-
-
0023135904
-
Factors influencing the sensitivity of two human bladder carcinoma cell lines to cis-diamminedichloroplatinum(II)
-
Bedford P, Walker MC, Sharma HL, Perera A, McAuliffe CA, Masters J, Hill BT (1987) Factors influencing the sensitivity of two human bladder carcinoma cell lines to cis-diamminedichloroplatinum(II). Chem Biol Interact 61:1
-
(1987)
Chem Biol Interact
, vol.61
, pp. 1
-
-
Bedford, P.1
Walker, M.C.2
Sharma, H.L.3
Perera, A.4
McAuliffe, C.A.5
Masters, J.6
Hill, B.T.7
-
5
-
-
0023111825
-
Characterization of a cis-diamminedichloroplatinum( II) resistant human ovarian cancer cell line and its use in evaluation of platinum analogues
-
Behrens BC, Hamilton TC, Masuda H, Grotzinger KR, Whang-Peng J et al (1987) Characterization of a cis-diamminedichloroplatinum( II) resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res 47:414
-
(1987)
Cancer Res
, vol.47
, pp. 414
-
-
Behrens, B.C.1
Hamilton, T.C.2
Masuda, H.3
Grotzinger, K.R.4
Whang-Peng, J.5
-
6
-
-
0026035533
-
Development and characterization of a melphalan-resistant human multiple myeloma cell line
-
Bellamy WT, Dalton WS, Gleason MC, Grogan TM, Trent JM (1991) Development and characterization of a melphalan-resistant human multiple myeloma cell line. Cancer Res 51:995
-
(1991)
Cancer Res
, vol.51
, pp. 995
-
-
Bellamy, W.T.1
Dalton, W.S.2
Gleason, M.C.3
Grogan, T.M.4
Trent, J.M.5
-
7
-
-
0014196981
-
Studies of the enzymatic deamination of cytosine arabinoside-II
-
Camiener GW (1967) Studies of the enzymatic deamination of cytosine arabinoside-II. Biochem Pharmacol 16:1681
-
(1967)
Biochem Pharmacol
, vol.16
, pp. 1681
-
-
Camiener, G.W.1
-
9
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27
-
-
Chou, T.C.1
Talalay, P.2
-
10
-
-
0037816604
-
Gemcitabine increases systemic 5-fluorouracil exposure in advanced cancer patients
-
Correal P, Cerretani D, Marsili S, Pozzessere D, Petrioli R, Messinese S, Sabatino M, Roviello F, Pinto E, Francini G, Giorgi G (2003) Gemcitabine increases systemic 5-fluorouracil exposure in advanced cancer patients. Eur J Cancer 39:1547
-
(2003)
Eur J Cancer
, vol.39
, pp. 1547
-
-
Correal, P.1
Cerretani, D.2
Marsili, S.3
Pozzessere, D.4
Petrioli, R.5
Messinese, S.6
Sabatino, M.7
Roviello, F.8
Pinto, E.9
Francini, G.10
Giorgi, G.11
-
11
-
-
0022485356
-
Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein
-
Dalton WS, Durie BG, Alberts DS, Gerlach JH, Cress AE (1986) Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein. Cancer Res 46:5125
-
(1986)
Cancer Res
, vol.46
, pp. 5125
-
-
Dalton, W.S.1
Durie, B.G.2
Alberts, D.S.3
Gerlach, J.H.4
Cress, A.E.5
-
12
-
-
0016430104
-
Combinations versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer
-
DeVita VT, Young RC, Canellos GP (1975) Combinations versus single agent chemotherapy: a review of the basis for selection of drug treatment of cancer. Cancer 35:98
-
(1975)
Cancer
, vol.35
, pp. 98
-
-
DeVita, V.T.1
Young, R.C.2
Canellos, G.P.3
-
14
-
-
26644446906
-
Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines
-
Dorr RT, Raymond MA, Landowski TH, Roman NO, Fukushima S (2005) Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines. Int J Gastrointest Cancer 36:15
-
(2005)
Int J Gastrointest Cancer
, vol.36
, pp. 15
-
-
Dorr, R.T.1
Raymond, M.A.2
Landowski, T.H.3
Roman, N.O.4
Fukushima, S.5
-
15
-
-
33947309495
-
Phase I trial of imexon in patients with advanced malignancy
-
in press
-
Dragovich T, Gordon M, Mendeslon D, Wong L, Modiano M, Chow S, Samulitis B, O'Day S, Greiner K, Hersh E, Dorr R (2007) Phase I trial of imexon in patients with advanced malignancy. J Clin Oncol (in press)
-
(2007)
J Clin Oncol
-
-
Dragovich, T.1
Gordon, M.2
Mendeslon, D.3
Wong, L.4
Modiano, M.5
Chow, S.6
Samulitis, B.7
O'Day, S.8
Greiner, K.9
Hersh, E.10
Dorr, R.11
-
16
-
-
0034666730
-
Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon
-
Dvorakova K, Payne CM, Tome ME, Briehl MM, McClure T, Dorr RT (2000) Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon. Biochem Pharmacol 60:749
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 749
-
-
Dvorakova, K.1
Payne, C.M.2
Tome, M.E.3
Briehl, M.M.4
McClure, T.5
Dorr, R.T.6
-
17
-
-
0035383778
-
Induction of mitochondrial changes in myeloma cells by imexon
-
Dvorakova K, Waltmire CN, Payne CM, Tome ME, Briehl MM, Dorr RT (2001) Induction of mitochondrial changes in myeloma cells by imexon. Blood 97:3544
-
(2001)
Blood
, vol.97
, pp. 3544
-
-
Dvorakova, K.1
Waltmire, C.N.2
Payne, C.M.3
Tome, M.E.4
Briehl, M.M.5
Dorr, R.T.6
-
18
-
-
12244256084
-
Imexon activates an intrinsic apoptosis pathway in RPMI 8226 myeloma cells
-
Dvorakova K, Payne CM, Landowski TH, Tome ME, Halperin DS, Dorr RT (2002) Imexon activates an intrinsic apoptosis pathway in RPMI 8226 myeloma cells. Anticancer Drugs 13:1
-
(2002)
Anticancer Drugs
, vol.13
, pp. 1
-
-
Dvorakova, K.1
Payne, C.M.2
Landowski, T.H.3
Tome, M.E.4
Halperin, D.S.5
Dorr, R.T.6
-
19
-
-
0032990022
-
Supraadditive effect of 2′.2′-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines
-
Faivre S, Raymond E, Woynarowski JM, Cvitkovic E (1999) Supraadditive effect of 2′.2′-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines. Cancer Chemother Pharmacol 44:117
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 117
-
-
Faivre, S.1
Raymond, E.2
Woynarowski, J.M.3
Cvitkovic, E.4
-
20
-
-
33644871517
-
Chemical blockage of the proteasome inhibitory function of bortezomib: Impact on tumor cell death
-
Fernandez Y, Miller TP, Denoyelle C, Esteban JA, Tang W-H, Benstson AL, Soengas ME (2006) Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death. J Biol Chem 281:1107-1118
-
(2006)
J Biol Chem
, vol.281
, pp. 1107-1118
-
-
Fernandez, Y.1
Miller, T.P.2
Denoyelle, C.3
Esteban, J.A.4
Tang, W.-H.5
Benstson, A.L.6
Soengas, M.E.7
-
21
-
-
0015462030
-
Combination cancer therapy: Presidential address
-
Frei E (1972) Combination cancer therapy: presidential address. Cancer Res 32:2593
-
(1972)
Cancer Res
, vol.32
, pp. 2593
-
-
Frei, E.1
-
22
-
-
2442451440
-
Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines
-
Giovannetti E, Mey V, Danesi R, Mosca I, Del Tacca M (2004) Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines. Clin Cancer Res 10:2936
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2936
-
-
Giovannetti, E.1
Mey, V.2
Danesi, R.3
Mosca, I.4
Del Tacca, M.5
-
23
-
-
0019197595
-
Combined chemotherapy
-
Goldin A (1980) Combined chemotherapy. Oncology 37:3
-
(1980)
Oncology
, vol.37
, pp. 3
-
-
Goldin, A.1
-
24
-
-
0037383192
-
Characterization of the MM.1 human multiple myeloma (MM) cell lines: A model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells
-
Greenstein S, Krett NL, Kurosawa Y, Ma C, Chauhan D, Hideshima T, Anderson KC, Rosen ST (2003) Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells. Exp Hematol 31:271
-
(2003)
Exp Hematol
, vol.31
, pp. 271
-
-
Greenstein, S.1
Krett, N.L.2
Kurosawa, Y.3
Ma, C.4
Chauhan, D.5
Hideshima, T.6
Anderson, K.C.7
Rosen, S.T.8
-
25
-
-
0023783698
-
Comparison of the cellular pharmacokinetics and toxicity of 2′,2′- difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine
-
Heinemann V, Hertel LW, Grindey GB, Plunkett W (1988) Comparison of the cellular pharmacokinetics and toxicity of 2′,2′- difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res 48(14):4024
-
(1988)
Cancer Res
, vol.48
, Issue.14
, pp. 4024
-
-
Heinemann, V.1
Hertel, L.W.2
Grindey, G.B.3
Plunkett, W.4
-
26
-
-
84965831807
-
Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies
-
Henderson EH, Samaha RJ (1969) Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies. Cancer Res 29:2272
-
(1969)
Cancer Res
, vol.29
, pp. 2272
-
-
Henderson, E.H.1
Samaha, R.J.2
-
27
-
-
0346100660
-
Chemical basis for the biological activity of imexon and related cyanoaziridines
-
Iyengar BS, Dorr RT, Remers WA (2004) Chemical basis for the biological activity of imexon and related cyanoaziridines. J Med Chem 47:218
-
(2004)
J Med Chem
, vol.47
, pp. 218
-
-
Iyengar, B.S.1
Dorr, R.T.2
Remers, W.A.3
-
28
-
-
14544268597
-
Prediction of docetaxel response in human breast cancer by gene expression profiling
-
Iwao-Koizumi K, Matoba R, Ueno N, Kim SJ, Ando A, Miyoshi Y, Maeda E, Noguchi S, Kato K (2005) Prediction of docetaxel response in human breast cancer by gene expression profiling. J Clin 23:422
-
(2005)
J Clin
, vol.23
, pp. 422
-
-
Iwao-Koizumi, K.1
Matoba, R.2
Ueno, N.3
Kim, S.J.4
Ando, A.5
Miyoshi, Y.6
Maeda, E.7
Noguchi, S.8
Kato, K.9
-
29
-
-
0036239375
-
Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: A new mode of catalytic inhibition
-
Jenson LH, Renodon-Corniere A, Wessel I, Langer SW, Sokilde B, Carstensen EV, Sehested M, Jensen PB (2002) Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: a new mode of catalytic inhibition. Mol Pharmacol 61:1235
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1235
-
-
Jenson, L.H.1
Renodon-Corniere, A.2
Wessel, I.3
Langer, S.W.4
Sokilde, B.5
Carstensen, E.V.6
Sehested, M.7
Jensen, P.B.8
-
30
-
-
4444235841
-
The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo
-
Kamat AM, Karashima T, Davis DW, Lashinger L, Bar-Eli M, Millikan R, Shen Y, Dinnery CPN, McConkey DJ (2004) The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo. Mol Cancer Ther 3:279
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 279
-
-
Kamat, A.M.1
Karashima, T.2
Davis, D.W.3
Lashinger, L.4
Bar-Eli, M.5
Millikan, R.6
Shen, Y.7
Dinnery, C.P.N.8
McConkey, D.J.9
-
31
-
-
0022457418
-
Mechanism of cytotoxicity of anticancer platinum drugs: Evidence that cis-diamminedichloro- platinum(II), and cis-diammine-(1,1-cyclobutanedicarboxylato)- platinum(II) differ only in the kinetics of their interactions with DNA
-
Knox RJ, Friedlos F, Lydall DA et al (1986) Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloro- platinum(II), and cis-diammine-(1,1-cyclobutanedicarboxylato)- platinum(II) differ only in the kinetics of their interactions with DNA. Cancer Res 46:1972
-
(1986)
Cancer Res
, vol.46
, pp. 1972
-
-
Knox, R.J.1
Friedlos, F.2
Lydall, D.A.3
-
32
-
-
0020070741
-
Activation by reduced glutathione of methotrexate transport into isolated rat liver cells
-
Leszczynska A, Pfaff E (1982) Activation by reduced glutathione of methotrexate transport into isolated rat liver cells. Biochem Pharmacol 31:1911
-
(1982)
Biochem Pharmacol
, vol.31
, pp. 1911
-
-
Leszczynska, A.1
Pfaff, E.2
-
33
-
-
0027309218
-
Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity
-
Liebmann JE, Hahn SM, Cook JA, Lipschulz C, Mitchell JB, Kaufman DC (1993) Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity. Cancer Res 53:2066
-
(1993)
Cancer Res
, vol.53
, pp. 2066
-
-
Liebmann, J.E.1
Hahn, S.M.2
Cook, J.A.3
Lipschulz, C.4
Mitchell, J.B.5
Kaufman, D.C.6
-
34
-
-
0022407471
-
A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1- cyclobutanedicarboxylato)-platinum(II) and cis- diamminedichloroplatinum(II) on L1210 cells
-
Micetich KC, Barnes D, Erickson LC (1985) A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1- cyclobutanedicarboxylato)-platinum(II) and cis- diamminedichloroplatinum(II) on L1210 cells. Cancer Res 45:4043
-
(1985)
Cancer Res
, vol.45
, pp. 4043
-
-
Micetich, K.C.1
Barnes, D.2
Erickson, L.C.3
-
35
-
-
22344434243
-
Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity
-
Minami T, Adachi M, Kawamura R, Zhang Y, Shinomura Y, Imai K (2005) Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity. Cancer Ther Preclin 11:5248
-
(2005)
Cancer Ther Preclin
, vol.11
, pp. 5248
-
-
Minami, T.1
Adachi, M.2
Kawamura, R.3
Zhang, Y.4
Shinomura, Y.5
Imai, K.6
-
36
-
-
0025816320
-
The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines
-
Mistry P, Kelland LR, Abel G, Sidhar S, Harrap KR (1991) The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. Br J Cancer 64:215
-
(1991)
Br J Cancer
, vol.64
, pp. 215
-
-
Mistry, P.1
Kelland, L.R.2
Abel, G.3
Sidhar, S.4
Harrap, K.R.5
-
37
-
-
17644445630
-
Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers
-
Park JS, Yamamoto W, Sekikawa T, Matsukawa M, Okamoto R, Sasaki M, Ukon K, Tanimoto K, Kumazaki T, Nishiyama M (2002) Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers. Int J Oncol 20:333
-
(2002)
Int J Oncol
, vol.20
, pp. 333
-
-
Park, J.S.1
Yamamoto, W.2
Sekikawa, T.3
Matsukawa, M.4
Okamoto, R.5
Sasaki, M.6
Ukon, K.7
Tanimoto, K.8
Kumazaki, T.9
Nishiyama, M.10
-
38
-
-
2542523228
-
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
-
Pei XY, Dai Y, Grant S (2004) Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin Cancer Res 10:3839
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3839
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
39
-
-
0023238688
-
Multiple mechanisms of cellular resistance to platinum coordination complexes
-
Richon VM, Schulte N, Eastman A (1987) Multiple mechanisms of cellular resistance to platinum coordination complexes. Cancer Res 47(8):2056
-
(1987)
Cancer Res
, vol.47
, Issue.8
, pp. 2056
-
-
Richon, V.M.1
Schulte, N.2
Eastman, A.3
-
40
-
-
33947326502
-
Imexon and gemcitabine are synergistic against human pancreatic cancer cells in vitro and in vivo
-
abst, 5884
-
Roman NO, Fukushima S, Raymond MA, Landowski T, Dorr RT (2005) Imexon and gemcitabine are synergistic against human pancreatic cancer cells in vitro and in vivo. In: AACr 96th annual meeting, abst # 5884, vol 46, p 1385
-
(2005)
AACr 96th annual meeting
, vol.46
, pp. 1385
-
-
Roman, N.O.1
Fukushima, S.2
Raymond, M.A.3
Landowski, T.4
Dorr, R.T.5
-
41
-
-
0025367455
-
Comparison of in vitro anticancer-drug- screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
-
Rubinstein LV, Shoemaker RH, Paull KD, Simon RM, Tosini S, Skehan P, Scudiero DA, Monks A, Boyd MR (1990) Comparison of in vitro anticancer-drug- screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 82:1113
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1113
-
-
Rubinstein, L.V.1
Shoemaker, R.H.2
Paull, K.D.3
Simon, R.M.4
Tosini, S.5
Skehan, P.6
Scudiero, D.A.7
Monks, A.8
Boyd, M.R.9
-
42
-
-
0014746823
-
Studies of the mechanism of action of the antitumor agent 5(4)-(3,3-dimethyl-1-triazeno) imidazole-4(5)-carboxamide in Bacillus subtilis
-
Saunders PP, Schultz GA (1970) Studies of the mechanism of action of the antitumor agent 5(4)-(3,3-dimethyl-1-triazeno) imidazole-4(5)-carboxamide in Bacillus subtilis. Biochem Pharmacol 19:911
-
(1970)
Biochem Pharmacol
, vol.19
, pp. 911
-
-
Saunders, P.P.1
Schultz, G.A.2
-
43
-
-
0026312972
-
Differential sensitivities of murine melanocytes and melanoma cells to buthionine sulfoximine and anticancer drugs
-
Thrall BD, Raha GA, Springer DL, Meadows GG (1991) Differential sensitivities of murine melanocytes and melanoma cells to buthionine sulfoximine and anticancer drugs. Pigment Cell Res 4:234
-
(1991)
Pigment Cell Res
, vol.4
, pp. 234
-
-
Thrall, B.D.1
Raha, G.A.2
Springer, D.L.3
Meadows, G.G.4
-
45
-
-
0036323457
-
Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells
-
Zhou B, Mi S, Mo X, Shih J, Tsai J, Hu E, Hsu M, Kay K, Yen Y (2002) Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells. Anitcancer Res 22:1369
-
(2002)
Anitcancer Res
, vol.22
, pp. 1369
-
-
Zhou, B.1
Mi, S.2
Mo, X.3
Shih, J.4
Tsai, J.5
Hu, E.6
Hsu, M.7
Kay, K.8
Yen, Y.9
|