Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide

Archives of Toxicology

Volumn 80, Issue 3, 2006, Pages 146-153

  Okuno, Takeo ^a   Matsuoka, Masato ^b   Sumizawa, Tomoyuki ^a   Igisu, Hideki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Acrylamide; ERK; p53; Phosphorylation; SH SY5Y cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACRYLAMIDE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN MDM2; PROTEIN P53; SERINE; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NEUROBLASTOMA CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOXICITY TESTING; WESTERN BLOTTING;

ACRYLAMIDE; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROBLASTOMA; PHOSPHORYLATION; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE;

EID: 33644613247     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0022-8     Document Type: Article

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