Comparison of the human skin grafted onto nude mouse model with in vivo and in vitro models in the prediction of percutaneous penetration of three lipophilic pesticides

Regulatory Toxicology and Pharmacology

Volumn 47, Issue 3, 2007, Pages 274-287

  Capt, A ^a   Luzy, A P ^a   Esdaile, D ^a   Blanck, O ^a  

^a Unit of Bee Pathology   (France)

Author keywords

Comparative study; Cypermethrin; Dermal penetration absorption; Human skin grafted onto nude mouse; HuSki; in vivo in vitro; Lindane; Malathion; Rat human; Stratum corneum

Indexed keywords

CIPERMETHRIN; LINDANE; MALATHION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSIMETRY; DRUG ABSORPTION; EXPERIMENTAL MODEL; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PREDICTION; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; SKIN GRAFT; SKIN PENETRATION; TOPICAL TREATMENT; TOXICOKINETICS;

ANIMALS; FEMALE; HUMANS; INSECTICIDES; LINDANE; MALATHION; MALE; MICE; MICE, NUDE; MODELS, ANIMAL; PYRETHRINS; RATS; RATS, WISTAR; RISK ASSESSMENT; SKIN ABSORPTION; SKIN TRANSPLANTATION;

MUS MUSCULUS; RATTUS;

EID: 33947255482     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2006.11.008     Document Type: Article

References (33)

1. Bartek M.J., LaBudde J.A., and Maibach H.I. Skin permeability in vivo: comparison in rat, rabbit, pig and man. J. Invest. Dermatol. 58 (1972) 114-123
2. Benford D.J., Cocker J., Sartorelli P., Schneider T., van Hemmen J., and Firth J.G. Dermal route in systemic exposure. Scand J. Work Environ. Health 25 (1999) 511-520
3. Bronaugh R.L., Stewart R.F., and Congdon E.R. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol. Appl. Pharmacol. 62 (1982) 481-488
4. Chu I., Dick D., Bronaugh R., and Tryphonas L. Skin reservoir formation and bioavailability of dermally administered chemicals in hairless guinea pigs. Food Chem. Toxicol. 34 (1996) 267-276
5. ECETOC (1993). Monograph n°20, percutaneous absorption. D.A. Stringer, (Ed.), Brussels, Belgium.
6. Elias P.M. Stratum corneum defensive functions: an integrated view. J. Invest. Dermatol. 125 (2005) 183-200
7. Elias P.M., Feingold K.R., Menon G.K., Grayson S., Williams M.L., and Grubauer G. the stratum corneum two-compartment model and its functional implications. In: Shroot B., and Schaefer H. (Eds). Skin Pharmakokinet. vol. 1 (1987), Karger, Basel 1-9
8. Elias P.M., and Menon G.K. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv. Lipid Res. 24 (1991) 1-26
9. Feldmann R.J., and Maibach H.I. Percutaneous penetration of some pesticides and herbicides in man. Toxicol. Appl. Pharmacol. 28 (1974) 126-132
10. Guy R.H., and Potts R.O. Penetration of industrial chemicals across the skin: a predictive model. Am. J. Ind. Med. 23 (1993) 711-719
11. Higounenc I., Spies F., Bodde H., Schaefer H., Demarchez M., Shroot B., and Ponec M. Lipid composition and barrier function of human skin after grafting onto athymic nude mice. Skin Pharmacol. 7 (1994) 167-175
12. Holleran W.M., Feingold K.R., Man M.Q., Gao W.N., Lee J.M., and Elias P.M. Regulation of epidermal sphingolipid synthesis by permeability barrier function. J. Lipid Res. 32 (1991) 1151-1158
13. Hood H.L., Wickett R.R., and Bronaugh R.L. In vitro percutaneous absorption of the fragrance ingredient musk xylol. Food Chem. Toxicol. 34 (1996) 483-488
14. Lauer A., Lieb L.M., et al. Transfollicular drug delivery. Pharm. Res. 12 (1995) 179-186
15. Lien E.J., and Gao H. QSAR analysis of skin permeability of various drugs in man as compared to in vivo and in vitro studies in rodents. Pharm. Res. 12 (1995) 583-587
16. Maibach H.I., Feldman R.J., Milby T.H., and Serat W.F. Regional variation in percutaneous penetration in man. Pesticides. Arch. Environ. Health 23 (1971) 208-211
17. OECD, 2000a. Environmental health and safety publications., Draft guidance document for the conduct of skin absorption studies, p. www1.oecd/ehs/test/guidancewebversion.pdf. Paris, december 2000.
18. OECD, 2000b. Test guideline program. Percutaneous absorption testing; is there a way to consensus? vol. OECD document ENV/JM/TG(2000). Paris, France.
19. OECD, 2004a. Guidance Document for the Conduct of Skin Absorption Studies. In: OECD Environmental Health and Safety Publications Series on testing and Assessment, vol. 28.
20. OECD, 2004b. Guideline for the Testing of Chemicals, Skin Absorption: in vitro Method. In OECD Guideline for the Testing of Chemicals, vol. Guideline No. 428.
21. OECD, 2004c. Guideline for the Testing of Chemicals, Skin Absorption: in vivo Method, vol. Guideline No. 427, OECD.
22. Pinnagoda J., Tupker R.A., Agner T., and Serup J. Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis. 22 (1990) 164-178
23. Ramsey J.D., Woollen B.H., Auton T.R., Batten P.L., and Leeser J.E. Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing. Hum. Exp. Toxicol. 11 (1992) 247-254
24. Reddy M.B., Guy R.H., and Bunge A.L. Does epidermal turnover reduce percutaneous penetration?. Pharm. Res. 17 (2000) 1414-1419
25. Reifenrath W.G., Chellquist E.M., Shipwash E.A., Jederberg W.W., and Krueger G.G. Percutaneous penetration in the hairless dog, weanling pig and grafted athymic nude mouse: evaluation of models for predicting skin penetration in man. Br. J. Dermatol. 111 Suppl. 27 (1984) 123-135
26. Schaefer, H., Redelmeier, T.E., 1996. Prediction and measurement of percutaneous absorption. In: Skin barrier: principles of percutaneous absorption (Karger, (Ed.), Basel).
27. Snedecor G.W., and Cochran W.G. T-test and modified t-test. In: Edition E. (Ed). Statistical methods-Chap 6. The comparison of two samples (1989), Iowa State University Press, Ames.
28. Sokal, R.R., Rohlf, F.J., 1981. F-Test. In: Biometry (W.H. Freeman, Ed.), p. pp. 189 190, New York.
29. Surber C., Wilhelm K.P., Maibach H.I., Hall L.L., and Guy R.H. Partitioning of chemicals into human stratum corneum: implications for risk assessment following dermal exposure. Fundam. Appl. Toxicol. 15 (1990) 99-107
30. US-EPA, 1998. Prevention, pesticides and toxic substances (7101), Health effects test guidelines, Dermal penetration. In Prevention, Pesticides and toxic substances (7101), Health effects test guidelines, vol. OPPTS 870.7600.
31. Van de Sandt J.J., Meuling W.J., Elliott G.R., Cnubben N.H., and Hakkert B.C. Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur. Toxicol. Sci. 58 (2000) 15-22
32. Woollen B.H., Marsh J.R., Laird W.J., and Lesser J.E. The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica 22 (1992) 983-991
33. Yourick J.J., Koenig M.L., Yourick D.L., and Bronaugh R.L. Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption?. Toxicol. Appl. Pharmacol. 195 (2004) 309-320