A nanoscopic multivalent antigen-presenting carrier for sensitive detection and drug delivery to T Cells

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 3, Issue 1, 2007, Pages 75-85

  Fahmy, Tarek M ^a   Schneck, Jonathan P ^b   Saltzman, W Mark ^a  

^a Yale University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Peptide loaded major histocompatibility complex; Polyamidoamine dendrimer; Polyethylene glycol; Streptavidin; T cell receptor

Indexed keywords

ANTIBODIES; CELLS; DISEASES; DRUG DELIVERY; POLYETHYLENE GLYCOLS;

PEPTIDE-LOADED MAJOR HISTOCOMPATIBILITY COMPLEX; POLYAMIDOAMINE DENDRIMERS; STREPTAVIDIN; T-CELL RECEPTOR;

ANTIGENS;

DOXORUBICIN; MACROGOL; POLYAMIDOAMINE; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; T LYMPHOCYTE; TARGET CELL;

ADOPTIVE TRANSFER; AMINES; ANIMALS; ANTIBODY AFFINITY; ANTIGEN PRESENTATION; ANTIGENS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; DENDRIMERS; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; MICE; NANOPARTICLES; PEPTIDES; POLYETHYLENE GLYCOLS; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES;

EID: 33947233339     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2006.11.010     Document Type: Article

References (30)

1. Klenerman P., Cerundolo V., and Dunbar P.R. Tracking T cells with tetramers: new tales from new tools. Nat Rev Immunol 2 4 (2002) 263-272
2. Howard M.C., Spack E.G., Choudhury K., Greten T.F., and Schneck J.P. MHC-based diagnostics and therapeutics-clinical applications for disease-linked genes. Immunol Today 20 4 (1999) 161-165
3. Schwartz R.H. T cell anergy. Annu Rev Immunol 21 (2003) 305-334
4. Casares S., Stan A.C., Bona C.A., and Brumeanu T.D. Antigen-specific downregulation of T cells by doxorubicin delivered through a recombinant MHC II-peptide chimera. Nat Biotechnol 19 2 (2001) 142-147
5. Garcia K.C., Tallquist M.D., Pease L.R., Brunmark A., Scott C.A., Degano M., et al. αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. Proc Natl Acad Sci U S A 94 25 (1997) 13838-13843
6. Fremont D.H., Rees W.A., and Kozono H. Biophysical studies of T-cell receptors and their ligands. Curr Opin Immunol 8 1 (1996) 93-100
7. Fahmy T.M., Bieler J.G., and Schneck J.P. Probing T cell membrane organization using dimeric MHC-Ig complexes. J Immunol Methods 268 1 (2002) 93-106
8. Luo D., Haverstick K., Belcheva N., Han E., and Saltzman W.M. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery. Macromolecules 35 9 (2002) 3456-3462
9. Schneck J.P. Monitoring antigen-specific T cells using MHC-Ig dimers. Immunol Invest 29 2 (2000) 163-169
10. Schneck J.P., Slansky J.E., Herrin S.M.O., and Greten T.F. Monitoring antigen-specific T cells using MHC-Ig dimers (2000), Wiley, New York 17.2.1-17.2.17
11. Kruisbeek A.M., and Shevach E.M. In vitro assays for mouse lymphocyte function. In: Current protocols in immunology. Current protocols in immunology (2004), Wiley, New York 3.12-1-3.12-20 [Section III: Assays for T cell Function]
12. Esfand R., and Tomalia D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today 6 8 (2001) 427-436
13. D'Emanuele A., and Attwood D. Dendrimer-drug interactions. Adv Drug Deliv Rev 57 15 (2005) 2147-2162
14. Jansen J.F.GA., de Brabander-van den Berg E.M., and Meijer E.W. Encapsulation of guest molecules into a dendritic box. Science 266 5188 (1994) 1226-1229
15. Jansen J.F.GA., Meijer E.W., and de Brabander-van den Berg E.M.M. The dendritic box-shape-selective liberation of encapsulated guests. J Am Chem Soc 117 15 (1995) 4417-4418
16. Kobayashi H., and Brechbiel M.W. Dendrimer-based macromolecular MRI contrast agents: characteristics and application. Mol Imaging 2 1 (2003) 1-10
17. Dennig J., and Duncan E. Gene transfer into eukaryotic cells using activated polyamidoamine dendrimers. J Biotechnol 90 3-4 (2002) 339-347
18. Yoo H., Sazani P., and Juliano R.L. PAMAM dendrimers as delivery agents for antisense oligonucleotides. Pharm Res 16 12 (1999) 1799-1804
19. Kobayashi H., Wu C., Kim M.K., Paik C.H., Carrasquillo J.A., and Brechbiel M.W. Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody. Bioconjug Chem 10 1 (1999) 103-111
20. Tomalia D.A., Naylor A.M., and Goddard W.A. Starburst dendrimers-molecular-level control of size, shape, surface-chemistry, topology, and flexibility from atoms to macroscopic matter. Angew Chem Int Ed Engl 29 2 (1990) 138-175
21. Sykulev Y., Brunmark A., Tsomides T.J., Kageyama S., Jackson M., and Peterson P.A. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc Natl Acad Sci U S A 91 24 (1994) 11487-11491
22. Dunbar P.R., and Ogg G.S. Oligomeric MHC molecules and their homologues: state of the art. J Immunol Methods 268 1 (2002) 3-7
23. Gerweck L.E., Kozin S.V., and Stocks S.J. The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells. Br J Cancer 79 5-6 (1999) 838-842
24. Roos A. Weak acids, weak bases, and intracellular pH. Respir Physiol 33 (1978) 27-30
25. Sykulev Y., Vugmeyster Y., Brunmark A., Ploegh H.L., and Eisen H.N. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity 9 4 (1998) 475-483
26. Altman J.D., Moss P.A., Goulder P.J., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274 5284 (1996) 94-96
27. Bromley S.K., Burack W.R., Johnson K.G., Somersalo K., Sims T.N., Sumen C., et al. The immunological synapse. Annu Rev Immunol 19 (2001) 375-396
28. Belcheva N., Baldwin S.P., and Saltzman W.M. Synthesis and characterization of polymer-(multi)-peptide conjugates for control of specific cell aggregation. J Biomat Sci Polym Ed 9 3 (1998) 207-226
29. Belcheva N., Woodrow-Mumford K., Mahoney M.J., and Saltzman W.M. Synthesis and biological activity of polyethylene glycol-mouse nerve growth factor conjugate. Bioconjug Chem 10 6 (1999) 932-937
30. Katre N. The conjugation of proteins with polyethylene glycol and other polymers. Altering properties of proteins to enhance their therapeutic potential. Adv Drug Delivery Rev 10 (1993) 91-114