Synthesis of β-1,4-di-d-mannuronic acid glycosides as potential ligands for toll-like receptors

Tetrahedron Letters

Volumn 48, Issue 16, 2007, Pages 2915-2918

  Jiang, Zi Hua ^a   Xu, Rongsong ^a   Wilson, Charlene ^a   Brenk, Agnes ^a  

^a LAKEHEAD UNIVERSITY   (Canada)

Author keywords

1,4 Di d mannuronic acid; Alginate; d Mannuronic acid; Glycolipid; Oligosaccharide; TLR ligand

Indexed keywords

ALGINIC ACID; GLYCOSIDE; IMMUNOSTIMULATING AGENT; MANNURONIC ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; GLYCOSIDATION; HOST RESISTANCE; INFECTION; INFLAMMATION; MALIGNANT NEOPLASTIC DISEASE; STEREOCHEMISTRY;

EID: 33947218834     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.02.086     Document Type: Article

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32. 3): δ 169.1, 168.1, 138.9, 138.7, 138.6, 138.0, 135.3, 135.1, 128.6, 128.5, 128.4, 128.3, 128.27, 128.2, 128.1, 128.0, 127.8, 127.7, 127.6, 127.4, 127.3, 127.2, 102.9, 102.1, 80.1, 79.4, 75.1, 75.0, 74.8, 74.6, 74.2, 73.7, 73.2, 72.3, 71.6, 70.5, 69.6, 68.0, 67.1, 66.9, 45.2, 31.9, 29.7, 29.6, 29.5, 29.3, 26.2, 22.7, 14.1.
33. +. A well resolved NMR spectrum was not obtained.
34. 2O): δ 173.2, 173.1, 101,3, 100.4, 78.3, 74.9, 74.3, 72.5, 71.5, 70.3, 69.6, 68.0, 57.3.