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Volumn 20, Issue 2, 2007, Pages 290-299

Determination of endogenous and exogenously derived N7-(2-hydroxyethyl) guanine adducts in ethylene oxide-treated rats

Author keywords

[No Author keywords available]

Indexed keywords

7 (2 HYDROXYETHYL)GUANINE; ETHYLENE OXIDE;

EID: 33947187356     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx600264t     Document Type: Article
Times cited : (28)

References (58)
  • 1
    • 0036897994 scopus 로고    scopus 로고
    • Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: Update review (1990-2001)
    • Kolman, A., Chovanec, M., and Osterman-Golkar, S. (2002) Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: Update review (1990-2001). Mutat. Res. 515, 173-194.
    • (2002) Mutat. Res , vol.515 , pp. 173-194
    • Kolman, A.1    Chovanec, M.2    Osterman-Golkar, S.3
  • 4
    • 0007885581 scopus 로고
    • Genesis and biogenesis of ethylene
    • Liberman, M., and Mapson, L. W. (1964) Genesis and biogenesis of ethylene. Nature 204, 343-345.
    • (1964) Nature , vol.204 , pp. 343-345
    • Liberman, M.1    Mapson, L.W.2
  • 5
    • 0024581717 scopus 로고
    • Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide
    • Törnqvist, M., Gustafsson, B., Kautiainen, A., Harms-Ringdahl, M., Granath, F., and Ehrenberg, L. (1989) Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide. Carcinogenesis 10, 39-41.
    • (1989) Carcinogenesis , vol.10 , pp. 39-41
    • Törnqvist, M.1    Gustafsson, B.2    Kautiainen, A.3    Harms-Ringdahl, M.4    Granath, F.5    Ehrenberg, L.6
  • 6
    • 0014962758 scopus 로고
    • A mechanism for the production of ethylene from methional
    • Beauchamp, C., and Fridovich, I. (1970) A mechanism for the production of ethylene from methional. J. Biol. Chem. 245, 4641-4646.
    • (1970) J. Biol. Chem , vol.245 , pp. 4641-4646
    • Beauchamp, C.1    Fridovich, I.2
  • 7
    • 0033810239 scopus 로고    scopus 로고
    • Carcinogenicity and genotoxicity of ethylene oxide: New aspects and recent advances
    • Thier, R., and Bolt, H. M. (2000) Carcinogenicity and genotoxicity of ethylene oxide: New aspects and recent advances. Crit. Rev. Toxicol. 30, 595-608.
    • (2000) Crit. Rev. Toxicol , vol.30 , pp. 595-608
    • Thier, R.1    Bolt, H.M.2
  • 9
    • 0018762707 scopus 로고
    • Leukaemia in workers exposed to ethylene oxide
    • Hogstedt, C., Malmqvist, N., and Wadman, B. (1979) Leukaemia in workers exposed to ethylene oxide. J. Am. Med. Assoc. 241, 1132-1133.
    • (1979) J. Am. Med. Assoc , vol.241 , pp. 1132-1133
    • Hogstedt, C.1    Malmqvist, N.2    Wadman, B.3
  • 10
    • 0018538698 scopus 로고
    • A cohort study of mortality and cancer incidence in ethylene oxide production workers
    • Hogstedt, C., Rohlen, O., Berndtsson, B., Axelson, O., and Ehrenberg, L. (1979) A cohort study of mortality and cancer incidence in ethylene oxide production workers. Br. J. Ind. Med. 36, 276-280.
    • (1979) Br. J. Ind. Med , vol.36 , pp. 276-280
    • Hogstedt, C.1    Rohlen, O.2    Berndtsson, B.3    Axelson, O.4    Ehrenberg, L.5
  • 11
    • 0022619964 scopus 로고
    • Epidemiologic support for ethylene-oxide as a cancer-causing agent
    • Hogstedt, C., Aringer, L., and Gustavsson, A. (1986) Epidemiologic support for ethylene-oxide as a cancer-causing agent. J. Am. Med. Assoc. 255, 1575-1578.
    • (1986) J. Am. Med. Assoc , vol.255 , pp. 1575-1578
    • Hogstedt, C.1    Aringer, L.2    Gustavsson, A.3
  • 12
    • 0033428770 scopus 로고    scopus 로고
    • Ethylene oxide cancer risk assessment based on epidemiological data: Application of revised regulatory guidelines
    • Teta, M. J., Sielken, R. L., and Valdez-Flores, C. (1999) Ethylene oxide cancer risk assessment based on epidemiological data: Application of revised regulatory guidelines. Risk Anal. 19, 1135-1155.
    • (1999) Risk Anal , vol.19 , pp. 1135-1155
    • Teta, M.J.1    Sielken, R.L.2    Valdez-Flores, C.3
  • 13
    • 1842558280 scopus 로고    scopus 로고
    • Mortality of British workers exposed to ethylene oxide: Extended follow up of a British cohort
    • Coggon, D., Harris, E. C., Poole, J., and Palmer, K. T. (2004) Mortality of British workers exposed to ethylene oxide: Extended follow up of a British cohort. Occup. Environ. Med. 61, 358-362.
    • (2004) Occup. Environ. Med , vol.61 , pp. 358-362
    • Coggon, D.1    Harris, E.C.2    Poole, J.3    Palmer, K.T.4
  • 14
    • 0346924345 scopus 로고    scopus 로고
    • Mortality analyses in a cohort of 18235 ethylene oxide exposed workers: Follow up extended from 1987 to 1998
    • Steenland, K., Stayner, J., and Deddens, J. (2004) Mortality analyses in a cohort of 18235 ethylene oxide exposed workers: Follow up extended from 1987 to 1998. Occup. Environ. Med. 61, 2-7.
    • (2004) Occup. Environ. Med , vol.61 , pp. 2-7
    • Steenland, K.1    Stayner, J.2    Deddens, J.3
  • 15
    • 0020532850 scopus 로고
    • Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide
    • Hogstedt, B., Gullberg, B., Hedner, K., Kolnig, A.-M., Mitelman, F., Skerfving, S., and Widegren, B. (1983) Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide. Hereditas 98, 105-113.
    • (1983) Hereditas , vol.98 , pp. 105-113
    • Hogstedt, B.1    Gullberg, B.2    Hedner, K.3    Kolnig, A.-M.4    Mitelman, F.5    Skerfving, S.6    Widegren, B.7
  • 16
    • 33947176451 scopus 로고
    • Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75-21-8) in BGC3F Mice (Inhalation Studies)
    • National Toxicology Program , Department of Health and Human Services, Research Triangle Park, NC
    • National Toxicology Program (1987) Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75-21-8) in BGC3F Mice (Inhalation Studies), Technical Report Series No. 326, Department of Health and Human Services, Research Triangle Park, NC.
    • (1987) Technical Report Series No , vol.326
  • 17
    • 0032984152 scopus 로고    scopus 로고
    • Cytogenetic effects of ethylene oxide, with an emphasis on population monitoring
    • Preston, R. J. (1999) Cytogenetic effects of ethylene oxide, with an emphasis on population monitoring. Crit. Rev. Toxicol. 29, 263-282.
    • (1999) Crit. Rev. Toxicol , vol.29 , pp. 263-282
    • Preston, R.J.1
  • 18
    • 0021214130 scopus 로고
    • A two-year inhalation study of the carcinogenic potential of ethylene oxide in Fischer 344 rats
    • Snellings, W. M., Weil, C. S., and Maronpot, A. (1984) A two-year inhalation study of the carcinogenic potential of ethylene oxide in Fischer 344 rats. Toxicol. Appl. Pharmacol. 75, 105-117.
    • (1984) Toxicol. Appl. Pharmacol , vol.75 , pp. 105-117
    • Snellings, W.M.1    Weil, C.S.2    Maronpot, A.3
  • 20
    • 0022655501 scopus 로고
    • Frequency, size and location of brain tumours in F-344 rats chronically exposed to ethylene oxide
    • Garman, R. H., and Snellings, W. M. (1986) Frequency, size and location of brain tumours in F-344 rats chronically exposed to ethylene oxide. Food Chem. Toxicol. 24, 145-153.
    • (1986) Food Chem. Toxicol , vol.24 , pp. 145-153
    • Garman, R.H.1    Snellings, W.M.2
  • 21
  • 22
    • 0027198881 scopus 로고
    • A mouse model for the study of in-vivo mutational spectra-Sequence specificity of ethylene oxide at the HPRT locus
    • Walker, V. E., and Skopek, T. R. ( 1993) A mouse model for the study of in-vivo mutational spectra-Sequence specificity of ethylene oxide at the HPRT locus. Mutat. Res. 288, 151-162.
    • (1993) Mutat. Res , vol.288 , pp. 151-162
    • Walker, V.E.1    Skopek, T.R.2
  • 23
    • 0042510534 scopus 로고    scopus 로고
    • Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl) guanine levels in Drosophila
    • Nivard, M. J. M., Czene, K., Segerbäck, D., and Vogel, E. E. (2003) Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl) guanine levels in Drosophila. Mutat. Res. 529, 95-107.
    • (2003) Mutat. Res , vol.529 , pp. 95-107
    • Nivard, M.J.M.1    Czene, K.2    Segerbäck, D.3    Vogel, E.E.4
  • 24
    • 0033976741 scopus 로고    scopus 로고
    • Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment
    • Van Sittert, N. J., Boogaard, P. J., Natarajan, A. T., Tates, A. D., Ehrenberg, L. G., and Tornqvist, M. A. (2000) Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment. Mutat. Res. 447, 27-48.
    • (2000) Mutat. Res , vol.447 , pp. 27-48
    • Van Sittert, N.J.1    Boogaard, P.J.2    Natarajan, A.T.3    Tates, A.D.4    Ehrenberg, L.G.5    Tornqvist, M.A.6
  • 25
    • 0030744798 scopus 로고    scopus 로고
    • In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure
    • Walker, V. E., Recio, L., Sisk, S. C., and Skopek, T. R. (1997) In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure. Mutat. Res. 392, 211-222.
    • (1997) Mutat. Res , vol.392 , pp. 211-222
    • Walker, V.E.1    Recio, L.2    Sisk, S.C.3    Skopek, T.R.4
  • 26
    • 2942583950 scopus 로고    scopus 로고
    • In vivo mutagenicity and mutation spectrum in the bone marrow and testes of B6C3F1 lacI transgenic mice following inhalation exposure to ethylene oxide
    • Recio, L., Donner, M., Abernethy, D., Pluta, L., Steen, A.-M., Wong, B. A., James, A., and Preston, R. J. (2004) In vivo mutagenicity and mutation spectrum in the bone marrow and testes of B6C3F1 lacI transgenic mice following inhalation exposure to ethylene oxide. Mutagenesis 19, 215-222.
    • (2004) Mutagenesis , vol.19 , pp. 215-222
    • Recio, L.1    Donner, M.2    Abernethy, D.3    Pluta, L.4    Steen, A.-M.5    Wong, B.A.6    James, A.7    Preston, R.J.8
  • 27
    • 0021145730 scopus 로고
    • Sister-chromatid exchanges and chromosome-aberrations in lymphocytes from monkeys exposed to ethylene-oxide and propylene-oxide by inhalation
    • Lynch, D. W., Lewis, T. R., Moorman, W. J., Burg, J. R., Gulati, D. K., Kaur, P., and Sabharwal, P. S. (1984) Sister-chromatid exchanges and chromosome-aberrations in lymphocytes from monkeys exposed to ethylene-oxide and propylene-oxide by inhalation. Toxicol. Appl. Pharmacol. 76, 85-95.
    • (1984) Toxicol. Appl. Pharmacol , vol.76 , pp. 85-95
    • Lynch, D.W.1    Lewis, T.R.2    Moorman, W.J.3    Burg, J.R.4    Gulati, D.K.5    Kaur, P.6    Sabharwal, P.S.7
  • 28
    • 0020628379 scopus 로고
    • Sister-chromatid exchange induction in peripheral-blood lymphocytes of rats exposed to ethylene-oxide by inhalation
    • Kligerman, A. D., Erexson, G. L., Phelps, M. E., and Wilmer, J. L. (1983) Sister-chromatid exchange induction in peripheral-blood lymphocytes of rats exposed to ethylene-oxide by inhalation. Mutat. Res. 120, 37-44.
    • (1983) Mutat. Res , vol.120 , pp. 37-44
    • Kligerman, A.D.1    Erexson, G.L.2    Phelps, M.E.3    Wilmer, J.L.4
  • 29
    • 0026788021 scopus 로고
    • Molecular dosimetry of ethylene oxide: Formation and persistence of N7-(2-hydroxyethyl)-guanine in DNA following repeated exposure of rats and mice
    • Walker, V. E., Fennell, T. R., Upton, P. B., Skopek, T. R., Prevost, V., Shuker, D. E. G., and Swenberg, J. A. (1992) Molecular dosimetry of ethylene oxide: formation and persistence of N7-(2-hydroxyethyl)-guanine in DNA following repeated exposure of rats and mice. Cancer Res. 52, 4328-4334.
    • (1992) Cancer Res , vol.52 , pp. 4328-4334
    • Walker, V.E.1    Fennell, T.R.2    Upton, P.B.3    Skopek, T.R.4    Prevost, V.5    Shuker, D.E.G.6    Swenberg, J.A.7
  • 30
    • 0025099493 scopus 로고
    • Reaction products in hemoglobin and DNA after in vitro treatment with ethylene oxide and N-(2-hydroxyethyl)-N- nitrosourea
    • Segerbäck, D. (1990) Reaction products in hemoglobin and DNA after in vitro treatment with ethylene oxide and N-(2-hydroxyethyl)-N- nitrosourea. Carcinogenesis 11, 307-312.
    • (1990) Carcinogenesis , vol.11 , pp. 307-312
    • Segerbäck, D.1
  • 31
    • 0026773508 scopus 로고
    • In vitro reaction of ethylene oxide with DNA and characterization of DNA adducts
    • Li, F., Segal, A., and Solomon, J. J. (1992) In vitro reaction of ethylene oxide with DNA and characterization of DNA adducts. Chem.-Biol. Interact. 83, 35-54.
    • (1992) Chem.-Biol. Interact , vol.83 , pp. 35-54
    • Li, F.1    Segal, A.2    Solomon, J.J.3
  • 34
    • 0028104592 scopus 로고
    • The role of 3-hydroxyethyldeoxyuridine in mutagenesis by ethylene oxide
    • Bhanot, O. S., Singh, U. S., and Solomon, J. J. (1994) The role of 3-hydroxyethyldeoxyuridine in mutagenesis by ethylene oxide. J. Biol. Chem. 269, 30056-30064.
    • (1994) J. Biol. Chem , vol.269 , pp. 30056-30064
    • Bhanot, O.S.1    Singh, U.S.2    Solomon, J.J.3
  • 35
    • 24944529168 scopus 로고    scopus 로고
    • Effects of ethylene oxide and ethylene inhalation of DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen and liver
    • Rusyn, I., Asakura, S., Li, Y., Kosyk, O., Koc, H., Nakamura, J., Upton, P. B., and Swenberg, J. A. (2005) Effects of ethylene oxide and ethylene inhalation of DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen and liver. DNA Repair 4, 1099-1110.
    • (2005) DNA Repair , vol.4 , pp. 1099-1110
    • Rusyn, I.1    Asakura, S.2    Li, Y.3    Kosyk, O.4    Koc, H.5    Nakamura, J.6    Upton, P.B.7    Swenberg, J.A.8
  • 36
    • 0030821017 scopus 로고    scopus 로고
    • A note on the physiological background of the ethylene oxide adduct 7-(2-hydroxyethyl)guanine in DNA from human blood
    • Bolt, H. M., Leutbecher, M., and Golka, K. (1997) A note on the physiological background of the ethylene oxide adduct 7-(2-hydroxyethyl)guanine in DNA from human blood. Arch. Toxicol. 71, 719-721.
    • (1997) Arch. Toxicol , vol.71 , pp. 719-721
    • Bolt, H.M.1    Leutbecher, M.2    Golka, K.3
  • 37
    • 0000643523 scopus 로고    scopus 로고
    • Endogenous and background DNA adducts by methylating and 2-hydroxyethylating agents
    • Zhao, C. Y., Tyndyk, M., Eide, I., and Hemminki, K. (1999) Endogenous and background DNA adducts by methylating and 2-hydroxyethylating agents. Mutat. Res. Fundam. Mol. Mech. Mutagen. 424, 117-125.
    • (1999) Mutat. Res. Fundam. Mol. Mech. Mutagen , vol.424 , pp. 117-125
    • Zhao, C.Y.1    Tyndyk, M.2    Eide, I.3    Hemminki, K.4
  • 38
    • 0031955471 scopus 로고    scopus 로고
    • The carcinogenic risk of ethene (ethylene)
    • Bolt, H. M. (1998) The carcinogenic risk of ethene (ethylene). Toxicol. Pathol. 26, 454-456.
    • (1998) Toxicol. Pathol , vol.26 , pp. 454-456
    • Bolt, H.M.1
  • 39
    • 33947131507 scopus 로고    scopus 로고
    • http://www.osha.gov/SLTC/ethyleneoxide/standards.html.
  • 40
    • 13844269360 scopus 로고    scopus 로고
    • Detection of DNA damage derived from a direct acting ethylating agent present in cigarette smoke by use of liquid chromatography-tandem mass spectrometry
    • Singh, R., Kaur, B., and Farmer, P. B. (2005) Detection of DNA damage derived from a direct acting ethylating agent present in cigarette smoke by use of liquid chromatography-tandem mass spectrometry. Chem. Res. Toxicol. 18, 249-256.
    • (2005) Chem. Res. Toxicol , vol.18 , pp. 249-256
    • Singh, R.1    Kaur, B.2    Farmer, P.B.3
  • 42
    • 0035062133 scopus 로고    scopus 로고
    • Quantitative detection of N7-(2-hydroxyethyl)guanine adducts in DNA using high performance liquid chromatography/electrospray ionisation tandem mass spectrometry
    • Liao, P.-C., Li, C.-M., Hung, C.-W., and Chen, S.-H. (2001) Quantitative detection of N7-(2-hydroxyethyl)guanine adducts in DNA using high performance liquid chromatography/electrospray ionisation tandem mass spectrometry. J. Mass Spectrom. 36, 336-343.
    • (2001) J. Mass Spectrom , vol.36 , pp. 336-343
    • Liao, P.-C.1    Li, C.-M.2    Hung, C.-W.3    Chen, S.-H.4
  • 43
    • 0032794871 scopus 로고    scopus 로고
    • A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring
    • Wu, K. Y., Scheller, N., Ranasinghe, A., Yen, T. Y., Sangaiah, R., Giese, R., and Swenberg, J. A. (1999) A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chem. Res. Toxicol. 18, 722-729.
    • (1999) Chem. Res. Toxicol , vol.18 , pp. 722-729
    • Wu, K.Y.1    Scheller, N.2    Ranasinghe, A.3    Yen, T.Y.4    Sangaiah, R.5    Giese, R.6    Swenberg, J.A.7
  • 44
    • 0031570082 scopus 로고    scopus 로고
    • High performance liquid chromatography/electrospray mass spectrometry for the analysis of modified bases in DNA: 7-(2-Hydroxyethyl)guanine, the major ethylene oxide-DNA adduct
    • Leclercq, L., Laurent, C., and De Pauw, E. (1997) High performance liquid chromatography/electrospray mass spectrometry for the analysis of modified bases in DNA: 7-(2-Hydroxyethyl)guanine, the major ethylene oxide-DNA adduct. Anal. Chem. 69, 1952-1955.
    • (1997) Anal. Chem , vol.69 , pp. 1952-1955
    • Leclercq, L.1    Laurent, C.2    De Pauw, E.3
  • 45
    • 0028987540 scopus 로고
    • 32P-Postlabelling method for the detection of 7-alkylguanine adducts formed by the reaction of different 1,2-alkyl epoxides with DNA
    • 32P-Postlabelling method for the detection of 7-alkylguanine adducts formed by the reaction of different 1,2-alkyl epoxides with DNA. Carcinogenesis 16, 483-489.
    • (1995) Carcinogenesis , vol.16 , pp. 483-489
    • Kumar, R.1    Staffas, J.2    Försti, A.3    Hemminki, K.4
  • 47
    • 0025318667 scopus 로고
    • Generation of volatile hydrocarbons from amino acids and proteins by an iron/ascorbate/GSH system
    • Kessler, W., and Remmer, H. (1990) Generation of volatile hydrocarbons from amino acids and proteins by an iron/ascorbate/GSH system. Biochem. Pharmacol. 39, 1347-1351.
    • (1990) Biochem. Pharmacol , vol.39 , pp. 1347-1351
    • Kessler, W.1    Remmer, H.2
  • 48
    • 0036125605 scopus 로고    scopus 로고
    • The in vivo levels of DNA alkylation products in human lymphocytes are not age dependent: An assay of 7-methyl- and 7-(2-hydroxyethyl)-guanine DNA adducts
    • Zhao, C., and Hemminki, K. (2002) The in vivo levels of DNA alkylation products in human lymphocytes are not age dependent: An assay of 7-methyl- and 7-(2-hydroxyethyl)-guanine DNA adducts. Carcinogenesis 23, 307-310.
    • (2002) Carcinogenesis , vol.23 , pp. 307-310
    • Zhao, C.1    Hemminki, K.2
  • 49
    • 1842527077 scopus 로고    scopus 로고
    • Formation of N-(2-hydroxyethyl)-valine in human haemoglobin-Effects of lifestyle factors
    • Wu, K. Y., Chiang, S. Y., Huang, T., Tseng, Y. S., Chen, Y. L., Kuo, H. W., and Hsieh, C. L. (2004) Formation of N-(2-hydroxyethyl)-valine in human haemoglobin-Effects of lifestyle factors. Mutat. Res. 559, 73-82.
    • (2004) Mutat. Res , vol.559 , pp. 73-82
    • Wu, K.Y.1    Chiang, S.Y.2    Huang, T.3    Tseng, Y.S.4    Chen, Y.L.5    Kuo, H.W.6    Hsieh, C.L.7
  • 50
    • 0025101244 scopus 로고
    • Formation of reactive species that lead to haemoglobin adducts during storage of blood samples
    • Törnqvist, M. (1990) Formation of reactive species that lead to haemoglobin adducts during storage of blood samples. Carcinogenesis 11, 51-54.
    • (1990) Carcinogenesis , vol.11 , pp. 51-54
    • Törnqvist, M.1
  • 51
    • 0035875433 scopus 로고    scopus 로고
    • A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat and human
    • Fennell, T. R., and Brown, C. D. (2001) A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat and human. Toxicol. Appl. Pharmacol. 173, 161-175.
    • (2001) Toxicol. Appl. Pharmacol , vol.173 , pp. 161-175
    • Fennell, T.R.1    Brown, C.D.2
  • 52
    • 0032841761 scopus 로고    scopus 로고
    • Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl)guantne formation in tissues of rodents
    • Wu, K. Y., Ranasinghe, A., Upton, P. B., Walker, V. E., and Swenberg, J. A. (1999) Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl)guantne formation in tissues of rodents. Carcinogenesis 20, 1787-1792.
    • (1999) Carcinogenesis , vol.20 , pp. 1787-1792
    • Wu, K.Y.1    Ranasinghe, A.2    Upton, P.B.3    Walker, V.E.4    Swenberg, J.A.5
  • 54
    • 0033851430 scopus 로고    scopus 로고
    • Biomarkers of exposures and effects as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide
    • Walker, V. E., Wu, K.-Y., Upton, P., Ranasinghe, A., Scheller, N., Cho, M.-Y., Vergenes, J. S., Skopek, T. R., and Swenberg, J. A. (2000) Biomarkers of exposures and effects as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide. Carcinogenesis 21, 1661-1669.
    • (2000) Carcinogenesis , vol.21 , pp. 1661-1669
    • Walker, V.E.1    Wu, K.-Y.2    Upton, P.3    Ranasinghe, A.4    Scheller, N.5    Cho, M.-Y.6    Vergenes, J.S.7    Skopek, T.R.8    Swenberg, J.A.9
  • 55
    • 0025013472 scopus 로고
    • Macromolecular adducts of ethylene oxide: A literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation
    • Walker, V. E., Fennell, T. R., Boucheron, J. A., Fedtke, N., Ciroussel, F., and Swenberg, J. A. (1990) Macromolecular adducts of ethylene oxide: A literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation. Mutat. Res. 233, 151-164.
    • (1990) Mutat. Res , vol.233 , pp. 151-164
    • Walker, V.E.1    Fennell, T.R.2    Boucheron, J.A.3    Fedtke, N.4    Ciroussel, F.5    Swenberg, J.A.6
  • 56
    • 0030025982 scopus 로고    scopus 로고
    • In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice
    • Brown, C. D., Wong, B. A., and Fennell, T. R. (1996) In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice. Toxicol. Appl. Pharmacol. 136, 8-19.
    • (1996) Toxicol. Appl. Pharmacol , vol.136 , pp. 8-19
    • Brown, C.D.1    Wong, B.A.2    Fennell, T.R.3
  • 57
    • 0024437899 scopus 로고
    • Lipid peroxidation and the metabolism of glutathione in rat liver and brain following ethylene oxide inhalation
    • Katoh, T., Higashi, K., Inoue, N., and Tanaka, I. (1989) Lipid peroxidation and the metabolism of glutathione in rat liver and brain following ethylene oxide inhalation. Toxicology 58, 1-9.
    • (1989) Toxicology , vol.58 , pp. 1-9
    • Katoh, T.1    Higashi, K.2    Inoue, N.3    Tanaka, I.4
  • 58
    • 3242776195 scopus 로고    scopus 로고
    • The application of accelerator mass spectrometry to pharmacology and toxicology
    • White, I. N. H., and Brown, K. (2004) The application of accelerator mass spectrometry to pharmacology and toxicology. Trends Pharm. Sci. 25, 442-447.
    • (2004) Trends Pharm. Sci , vol.25 , pp. 442-447
    • White, I.N.H.1    Brown, K.2


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