A note on the physiological background of the ethylene oxide adduct 7-(2-hydroxymethyl)guanine in DNA from human blood

Archives of Toxicology

Volumn 71, Issue 11, 1997, Pages 719-721

  Bolt, Hermann M ^a   Leutbecher, Monika ^a   Golka, Klaus ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

7 (2 Hydroxyethyl)guanine; DNA adducts; Ethylene; Ethylene oxide

Indexed keywords

7 (2 HYDROXYETHYL)GUANINE; ETHYLENE; ETHYLENE OXIDE;

ARTICLE; BLOOD; CANCER RISK; DNA ADDUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0030821017     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050451     Document Type: Article

References (11)

1. Bolt HM (1996) Quantification of endogenous carcinogens. The ethylene oxide paradox. Biochem Pharmacol 52: 1-5
2. Bolt HM (1997) Risiken durch Stoffe am Arbeitsplatz; Möglichkeiten der Quantifizierung des endogenen Risikos. Gefahrstoffe - Reinhaltung der Luft, vol 6-9
3. Bolt HM, Leutbecher M (1993) Dose-DNA adduct relationship for ethylene oxide. Arch Toxicol 67: 712-713
4. Filser JG, Kreuzer, PE, Greim H, Bolt HM (1994) New scientific arguments for regulation of ethylene oxide residues in skin-care products. Arch Toxicol 68: 401-405
5. Föst U, Marczynski B, Kasemann R, Peter H (1989) Determination of 7-(2-hydroxyethyl)guanine with gas chromatography mass spectrometry as a parameter for genotoxicity of ethylene oxide. Arch Toxicol Suppl 13: 250-253
6. Granath F, Rohlén O, Göransson C, Hansson L, Magnusson AL, Törnqvist M (1996) Relationship between dose in vivo of ethylene oxide and exposure to ethene studied in exposed workers. Hum Exp Toxicol 15: 825-833
7. Leutbecher M (1995) Untersuchungen zur DNA-Bindungsfähigkeit von Ethylenoxid und 2-Methylpropenmetaboliten. Thesis,University Dortmund. Cuvillier, Göttingen
8. Miller SA, Dykes DD, Polesky HF (1988) A simple procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215
9. Nath RG, Randerath K, Li D, Chung FL (1996) Endogenous production of DNA adducts. Regul Toxicol Pharmacol 23: 22-28
10. Törnqvist M, Gustafsson B, Kautiainen A, Harms-Ringdahl M, Granath F, Ehrenberg L (1989) Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethylene and ethylene oxide. Carcinogenesis 10: 39-41
11. Walker VE, Fennell TR, Upton PB, Skopek TR, Prevost V, Shuker DEG, Swenberg JA (1992) Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice. Cancer Res 52: 4328-4334