A novel element regulates expression of the proximal human proglucagon promoter in islet cells

General and Comparative Endocrinology

Volumn 151, Issue 2, 2007, Pages 230-239

  Tsai, Brian ^a,b   Yue, Shijun ^a,b   Irwin, David M ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Evolution; Expression; Gene expression; Glucagon; Islet; Mammals; Pancreatic islet; Proglucagon

Indexed keywords

NUCLEOTIDE; PROGLUCAGON;

ANIMAL CELL; ARTICLE; ARTIODACTYLA; CARNIVORE; CONTROLLED STUDY; DNA FLANKING REGION; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MAMMAL; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; PANCREAS ISLET CELL; PRIMATE; PRIORITY JOURNAL; PROMOTER REGION; RAT; REGULATOR GENE; RHESUS MONKEY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

EID: 33947185194     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2007.01.012     Document Type: Article

References (43)

1. Anini Y., and Brubaker P.L. Glucagon-like peptides: GLP-1 and GLP-2. In: Henry H.L., and Norman A.W. (Eds). Encyclopedia of Hormones Vol. 2 (2003), Academic Press, Boston 55-62
2. Bell G.I., Santerre R.F., and Mullenbach G.T. Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302 (1983) 716-718
3. Chen Y.E., and Drucker D.J. Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard. J. Biol. Chem. 272 (1997) 4108-4115
4. Drucker D.J. The glucagon-like peptides. Endocrinology 142 (2001) 521-527
5. Drucker D.J. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122 (2002) 531-544
6. Drucker D.J. Glucagon gene expression. In: Henry H.L., and Norman A.W. (Eds). Encyclopedia of Hormones vol. 2 (2003), Academic Press, Boston 47-55
7. Drucker D.J., Philippe J., Jepal L., and Habener J.F. Glucagon gene 5′-flanking sequences promote islet cell-specific glucagon gene transcription. J. Biol. Chem. 262 (1987) 15659-15665
8. Drucker D.J., Jin T., Asa S.L., Young T.A., and Brubaker P.L. Activation of proglucagon gene by protein kinase A in a novel enteroendocrine cell line. Mol. Endocrinol. 8 (1994) 1646-1655
9. Efrat S., Teitelman G., Anwar D., Ruggiero D., and Hanahan D. Glucagon gene regulatoryregion directs oncoprotein expression to neurons and pancreatic a cells. Neuron 1 (1988) 605-613
10. Farre D., Roset R., Huerta M., Adsuara J.E., Rosello L., Alba M.M., and Messenguer X. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res. 31 (2003) 3651-3653
11. Hussain M.A., Daniel P.B., and Habener J.F. Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic β-cells. Diabetes 49 (2000) 1681-2000
12. Inada A., Yamada Y., Someya Y., Kubota A., Yasuda K., Ihara Y., Kagimoto S., Kuroe A., Tsuda K., and Seino Y. Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats. Biochem. Biophys. Res. Commun. 253 (1998) 712-718
13. Inada A., Someya Y., Yamada Y., Ihara Y., Kubota A., Ban N., Watanabe R., Tsuda K., and Seino Y. The cyclic AMP reponse element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. J. Biol. Chem. 274 (1999) 21095-21103
14. Irwin D.M. cDNA cloning of proglucagon from the stomach and pancreas of the dog. DNA Seq. 12 (2001) 253-260
15. Irwin D.M. Ancient duplications of the human proglucagon gene. Genomics 79 (2002) 741-746
16. Irwin D.M., and Gong Z. Molecular evolution of vertebrate goose-type lysozyme genes. J. Mol. Evol. 56 (2003) 234-242
17. Irwin D.M., and Wong J. Trout and chicken proglucagon: alternative splicing generates mRNA transcripts encoding glucagon-like peptide 2. Mol. Endocrinol. 9 (1995) 267-277
18. Irwin D.M., Sidow A., White R.T., and Wilson A.C. Multiple genes for ruminant lysozymes. In: Smith-Gill S.J., and Sercarz E.E. (Eds). The Immune Response to Structurally Defined Proteins: The Lysozyme Model (1989), Adenine Press, Schenectady, NY 73-85
19. Irwin D.M., Satkunarajah M., Wen Y., Brubaker P.L., Pederson R.A., and Wheeler M.B. The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties. Proc. Natl. Acad. Sci. USA 94 (1997) 7915-7920
20. Irwin D.M., Huner O., and Youson J.H. Lamprey proglucagon and the origin of glucagon-like peptides. Mol. Biol. Evol. 16 (1999) 1548-1557
21. Jiang G., and Zhang B.B. Glucagon and regulation of glucose metabolism. Am. J. Physiol. 284 (2003) E671-E678
22. Jin T., and Drucker D.J. The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription. Mol. Endocrinol. 9 (1995) 1306-1320
23. Kieffer T.J., and Habener J.F. The glucagon-like peptides. Endocrine Rev. 20 (1999) 876-913
24. Lalli E., and Sassone-Corsi P. Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem. 269 (1994) 17359-17362
25. Leung-Theung-Long S., Roulet E., Clerc P., Escrieut C., Marchal-Victorion S., Ritz-Laser B., Philippe J., Pradayrol L., Seva C., Fourmy D., and Dufresne M. Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells. J. Biol. Chem. 280 (2005) 7976-7984
26. Lopez L.C., Frazier M.L., Su C.J., Kumar A., and Saunders G.F. Mammalian pancreatic preproglucagon contains three glucagon-related peptides. Proc. Natl. Acad. Sci. USA 80 (1983) 5485-5489
27. Macpherson I. Characterization of a hamster cell clone transformed by polyoma virus. J. Natl. Cancer Inst. 30 (1963) 795-815
28. Murphy W.J., Pevzner P.A., and O'Brien S.J. Mammalian phylogenomics comes of age. Trends Genet. 20 (2004) 631-639
29. Nian M., Drucker D.J., and Irwin D. Divergent regulation of human and rat proglucagon gene promoters in vivo. Am. J. Physiol. 277 (1999) G829-G837
30. Philippe J. Structure and pancreatic expression of the insulin and glucagon genes. Endocr. Rev. 12 (1991) 252-271
31. Powers A.C., Efrat S., Mojsov S., Spector D., Habener J.F., and Hanahan D. Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes 39 (1990) 406-414
32. Rothenberg M.E., Eilertson C.D., Klein K., Zhou Y., Lindberg I., McDonald J.K., Mackin R.B., and Noe B.D. Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro. J. Biol. Chem. 270 (1995) 10136-10146
33. Schwartz S., Zhang Z., Frazer K.A., Smit A., Riemer C., Bouck J., Gibbs R., Hardison R., and Miller W. PipMaker-a web server for aligning two genomic DNA sequences. Genome Res. 10 (2000) 577-586
34. Steiner D.F. Glucagon processing. In: Henry H.L., and Norman A.W. (Eds). Encyclopedia of Hormones vol. 2 (2003), Academic Press, Boston 65-74
35. Swanson K.W., Irwin D.M., and Wilson A.C. Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection. J. Mol. Evol. 33 (1991) 418-425
36. Takaki R., Ono J., Nakamura M., Yokogawa Y., Kumae S., Hiraoka T., Yamaguchi K., Hamaguchi K., and Uchida S. Isolation of glucagon-secreting cell lines by cloning insulinoma cells. In vitro Cel. Dev. Biol. 22 (1986) 120-126
37. Thompson J.D., Higgins D.G., and Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994) 4673-4680
38. White J.W., and Saunders G.F. Structure of the human glucagon gene. Nucleic Acids Res. 14 (1986) 4719-4730
39. Yeung C.M., and Chow B.K. Identification of a proglucagon cDNA from Rana tigrina rugulosa that encodes two GLP-1s and that is alternatively spliced in a tissue-specific manner. Gen. Comp. Endocrinol. 124 (2001) 144-151
40. Yue S., and Irwin D.M. Structure and expression of the chicken proglucagon gene. Mol. Cell. Endocrinol. 230 (2005) 69-76
41. Zhou L., and Irwin D.M. Fish proglucagon genes have differing coding potential. Comp. Biochem. Physiol. 137B (2004) 255-264
42. Zhou Y.-P., Marlen K., Palma J.F., Schweitzer A., Reilly L., Gregoire F.M., Xu G.G., Blume J.E., and Johnson J.D. Overexpression of repressive cAMP responsive element modulators in high glucose and fatty acid-treated rat islets. J. Biol. Chem. 278 (2003) 51316-51323
43. Zhou L., Nian M., Gu J., and Irwin D.M. Intron 1 sequences are required for pancreatic expression of the human proglucagon gene. Am. J. Physiol. 290 (2006) R634-R641