Increased neuronal nitric oxide synthase interaction with soluble guanylate cyclase contributes to the splanchnic arterial vasodilation in portal hypertensive rats

Hepatology Research

Volumn 37, Issue 1, 2007, Pages 58-67

  Kwon, So Young ^a,c   Groszmann, Roberto J ^a,b   Iwakiri, Yasuko ^a,b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Konkuk University Hospital   (South Korea)

Author keywords

Liver diseases; Nitricoxide; nNOS; Vasodilation

Indexed keywords

7 NITROINDAZOLE; GUANYLATE CYCLASE; METHOXAMINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; IMMUNOPRECIPITATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SMOOTH MUSCLE FIBER; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY; VASCULAR ENDOTHELIUM; VEIN LIGATION;

EID: 33947183965     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2007.00005.x     Document Type: Article

References (37)

1. Sieber CC, Lopez-Talavera JC, Groszmann RJ. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993 ; 104: 1750-4.
2. Lee FY, Colombato LA, Albillos A, Groszmann RJ. N omega-nitro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension and ameliorates plasma Volume expansion and sodium retention in portal hypertensive rats. Hepatology 1993 ; 17: 84-90.
3. Pizcueta P, Pique JM, Fernandez M et al. Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Gastroenterology 1992 ; 103: 1909-15.
4. Pollock JS, Forstermann U, Mitchell JA et al. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci USA 1991 ; 88: 10480-4.
5. Segal SS, Brett SE, Sessa WC. Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters. Am J Physiol 1999 ; 277: H1167-77.
6. Boulanger CM, Heymes C, Benessiano J et al. Neuronal nitric oxide synthase is expressed in rat vascular smooth muscle cells: Activation by angiotensin II in hypertension. Circ Res 1998 ; 83: 1271-8.
7. Cahill PA, Redmond EM, Hodges R et al. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatology 1996 ; 25: 370-8.
8. Atucha NM, Shah V, Garcia-Cardena G et al. Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenterology 1996 ; 111: 1627-32.
9. Shah V, Wiest R, Garcia-Cardena G et al. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol 1999 ; 277: G463-8.
10. Niederberger M, Gines P, Martin PY et al. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 1996 ; 24: 947-51.
11. Wiest R, Shah V, Sessa WC, Groszmann RJ. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol 1999 ; 276: G1043-51.
12. Hori N, Wiest R, Groszmann RJ. Enhanced release of nitric oxide in response to changes in flow and shear stress in the superior mesenteric arteries of portal hypertensive rats. Hepatology 1998 ; 28: 1467-73.
13. Garcia-Pagan JC, Fernandez M, Bernadich C et al. Effects of continued NO inhibition on portal hypertensive syndrome after portal vein stenosis in rat. Am J Physiol 1994 ; 267: G984-90.
14. Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol 2002 ; 283: G1074-81.
15. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990 ; 347: 768-70.
16. Sullivan JC, Pollock DM, Pollock JS. Altered nitric oxide synthase 3 distribution in mesenteric arteries of hypertensive rats. Hypertension 2002 ; 39: 597-602.
17. Bernhardt J, Tschudi MR, Dohi Y et al. Release of nitric oxide from human vascular smooth muscle cells. Biochem Biophys Res Commun 1991 ; 180: 907-12.
18. Papadaki M, Tilton RG, Eskin SG, McIntire LV. Nitric oxide production by cultured human aortic smooth muscle cells: Stimulation by fluid flow. Am J Physiol 1998 ; 274: H616-26.
19. Xu L, Carter EP, Ohara M et al. Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis. Am J Physiol Renal Physiol 2000 ; 279: F1110-5.
20. Jurzik L, Froh M, Straub RH et al. Upregulation of nNOS and associated increase in nitrergic vasodilation in superior mesenteric arteries in pre-hepatic portal hypertension. J Hepatol 2005 ; 43: 258-65.
21. Ignarro LJ, Buga GM, Wood KS et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987 ; 84: 9265-9.
22. Sikuler E, Kravetz D, Groszmann RJ. Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model. Am J Physiol 1985 ; 248: G618-25.
23. Colombato LA, Albillos A, Groszmann RJ. Temporal relationship of peripheral vasodilatation, plasma Volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats. Hepatology 1992 ; 15: 323-8.
24. McGregor D. The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric vessels of the rat. J Physiol 1965 ; 177: 21-30.
25. Iwakiri Y, Tsai MH, McCabe TJ et al. Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. Am J Physiol Heart Circ Physiol 2002 ; 282: H2084-90.
26. Tsai MH, Iwakiri Y, Cadelina G et al. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology 2003 ; 125: 1452-61.
27. Sullivan JC, Giulumian AD, Pollock DM et al. Functional NOS 1 in the rat mesenteric arterial bed. Am J Physiol Heart Circ Physiol 2002 ; 283: H658-63.
28. Topors M, Monge JC, Stewart DJ, Hussain SNA. Endothelin-1 stimulates NO release from proliferating vascular smooth muscle cells: Evidence for constitutive nitric oxide synthase expression. Circ Suppl I 1995 ; 92: I-564.
29. Saur D, Neuhuber WL, Gengenbach B et al. Site-specific gene expression of nNOS variants in distinct functional regions of rat gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2002 ; 282: G349-58.
30. Huber A, Saur D, Kurjak M et al. Characterization and splice variants of neuronal nitric oxide synthase in rat small intestine. Am J Physiol 1998 ; 275: G1146-56.
31. Lee MA, Cai L, Hubner N et al. Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase. J Clin Invest 1997 ; 100: 1507-12.
32. Hall AV, Antoniou H, Wang Y et al. Structural organization of the human neuronal nitric oxide synthase gene (NOS1). J Biol Chem 1994 ; 269: 33082-90.
33. Saur D, Paehge H, Schusdziarra V, Allescher HD. Distinct expression of splice variants of neuronal nitric oxide synthase in the human gastrointestinal tract. Gastroenterology 2000 ; 118: 849-58.
34. Wang Y, Newton DC, Robb GB et al. RNA diversity has profound effects on the translation of neuronal nitric oxide synthase. Proc Natl Acad Sci USA 1999 ; 96: 12150-5.
35. Moore PK, Bland-Ward PA. 7-nitroindazole: An inhibitor of nitric oxide synthase. Methods Enzymol 1996 ; 268: 393-8.
36. Moore PK, Babbedge RC, Wallace P et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 1993 ; 108: 296-7.
37. Ayajiki K, Fujioka H, Okamura T, Toda N. Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries. Eur J Pharmacol 2001 ; 423: 179-83.