Mesenteric Vasoconstriction Triggers Nitric Oxide Overproduction in the Superior Mesenteric Artery of Portal Hypertensive Rats

Gastroenterology

Volumn 125, Issue 5, 2003, Pages 1452-1461

  Tsai, Ming Hung ^a,b   Iwakiri, Yasuko ^a,b,c   Cadelina, Gregory ^a   Sessa, William C ^c   Groszmann, Roberto J ^a,b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; METHOXAMINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY LIGATION; ARTICLE; CATHETERIZATION; CONTROLLED STUDY; DOPPLER FLOWMETER; ENZYME ACTIVITY; HEMODYNAMICS; KIDNEY ARTERY LIGATION; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC BLOOD VESSEL OCCLUSION; MESENTERY BLOOD FLOW; NONHUMAN; PERFUSION PRESSURE; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PORTAL VEIN LIGATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUPERIOR MESENTERIC ARTERY; VASCULAR RESISTANCE; VASOCONSTRICTION; VEIN LIGATION;

EID: 0242490247     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gastro.2003.07.014     Document Type: Article

References (35)

1. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A 1987;84:9265-9269.
2. Cahill PA, Foster C, Redmond EM, Gingalewski C, Wu Y, Sitzmann JV. Enhanced nitric oxide synthase activity in portal hypertensive rabbits. Hepatology 1995;22:598-606.
3. Martin PY, Xu DL, Niederberger M, Weigert A, Tsai P, St John J, Gines P, Schrier RW. Upregulation of endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am J Physiol 1996;270:F494-F499.
4. Niederberger M, Gines P, Martin PY, Tsai P, Morris K, McMurtry I, Schrier RW. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 1996;24:947-951.
5. Niederberger M, Martin PY, Gines P, Morris K, Tsai P, Xu DL, McMurtry I, Schrier RW. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 1995;109:1624-1630.
6. Groszmann RJ, Loureiro-Silva M, Tsai MH. The biology of portal hypertension. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Schafritz D, eds. The liver: biology and pathobiology. 4th ed. New York: Lippincott Williams & Wilkins, 2001:679-697.
7. Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol 1983;244:G52-G57.
8. Colombato LA, Albillos A, Groszmann RJ. Temporal relationship of peripheral vasodilatation, plasma volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats. Hepatology 1992;15:323-328.
9. Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC. The phosphorylation of endothelial nitric oxide synthase initiates excessive nitric oxide production in the early phases of portal hypertension. Am J Physiol 2002;282:H2084-H2090.
10. Wiest R, Shah V, Sessa WC, Groszmann RJ. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol 1999;276:G1043-G1051.
11. Sikuler E, Kravetz D, Groszmann RJ. Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model. Am J Physiol 1985;248:G618-G625.
12. Morgan JS, Groszmann RJ, Rojkind M, Enriquez R. Hemodynamic mechanisms of emerging portal hypertension caused by schistosomiasis in the hamster. Hepatology 1990;11:98-104.
13. de Wit C, Jahrbeck B, Schafer C, Bolz SS, Pohl U. Nitric oxide opposes myogenic pressure responses predominantly in large arterioles in vivo. Hypertension 1998;31:787-794.
14. Pohl U, de Wit C. Interaction of nitric oxide with myogenic and adrenergic vasoconstrictor processes in the control of microcirculatory blood flow. Pflugers Arch 1996;432:R107-R110.
15. Juncos LA, Garvin J, Carretero OA, Ito S. Flow modulates myogenic responses in isolated microperfused rabbit afferent arterioles via endothelium-derived nitric oxide. J Clin Invest 1995;95:2741-2748.
16. Meininger GA, Routh LK, Granger HJ. Autoregulation and vasoconstriction in the intestine during acute renal hypertension. Hypertension 1985;7:364-373.
17. Jalan R, Forrest EH, Redhead DN, Dillon JF, Hayes PC. Reduction in renal blood flow following acute increases in the portal pressure: evidence for the existence of a hepatorenal reflex in man? Gut 1997;40:664-670.
18. Lang F, Tschernko E, Schule E, Ottl I, Ritter M, Volkl H, Hallbrucker C, Haussinger D. Hepatorenal reflex regulating kidney function. Hepatology 1991;14:590-594.
19. Niederberger M, Schrier RW. Pathogenesis of sodium and water retention in liver disease. Prog Liver Dis 1992;10:329-347.
20. Chen L, Groszmann RJ. Blood in the gastric lumen increases splanchnic blood flow and portal pressure in portal-hypertensive rats. Gastroenterology 1996;111:1103-1110.
21. McGregor D. The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric vessels of the rat. J Physiol 1965;177:21-30.
22. Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstien S, Groszmann RJ. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. J Clin Invest 1999;104:1223-1233.
23. Sieber CC, Groszmann RJ. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992;103:235-239.
24. Haywood JR, Shaffer RA, Fastenow C, Fink GD, Brody MJ. Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am J Physiol 1981;241:H273-H278.
25. Colombato LA, Sabba C, Polio J, Groszmann RJ. Influence of anesthesia, postanesthetic state, and restraint on superior mesenteric arterial flow in normal rats. Am J Physiol 1991;260:G1-G6.
26. Cahill PA, Redmond EM, Hodges R, Zhang S, Sitzmann JV. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatol 1996;25:370-378.
27. Bayliss WM. On the local changes of the arterial wall to changes of internal pressure. J Physiol 1902;28:220-231.
28. Selkurt EE, Johnson PC. Effect of acute elevation of portal venous pressure on mesenteric blood volume, interstitial fluid volume and hemodynamics. Circ Res 1958;6:592-599.
29. Scotland RS, Chauhan S, Vallance PJ, Ahluwalia A. An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. Hypertension 2001;38:833-839.
30. Ming Z, Han C, Lautt WW. Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction. Am J Physiol 1999;277:G1200-G1206.
31. Hecker M, Mulsch A, Bassenge E, Busse R. Vasoconstriction and increased flow: two principal mechanisms of shear stress-dependent endothelial autacoid release. Am J Physiol 1993;265:H828-H833.
32. Llach J, Gines P, Arroyo V, Rimola A, Tito L, Badalamenti S, Jimenez W, Gaya J, Rivera F, Rodes J. Prognostic value of arterial pressure, endogenous vasoactive systems, and renal function in cirrhotic patients admitted to the hospital for the treatment of ascites. Gastroenterology 1988;94:482-487.
33. Koller A, Bagi Z. On the role of mechanosensitive mechanisms eliciting reactive hyperemia. Am J Physiol 2002;283:H2250-H2259.
34. Dora KA, Doyle MP, Duling BR. Elevation of intracellular calcium in smooth muscle causes endothelial cell generation of NO in arterioles. Proc Natl Acad Sci U S A 1997;94:6529-6534.
35. Sun D, Huang A, Recchia FA, Cui Y, Messina EJ, Koller A, Kaley G. Nitric oxide-mediated arteriolar dilation after endothelial deformation. Am J Physiol 2001;280:H714-H721.