T-bet expression in the iris and spleen parallels disease expression during endotoxin-induced uveitis

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 245, Issue 3, 2007, Pages 407-413

  Li, Bing ^a,b,c   Yang, Peizeng ^a,b,c   Chu, Liqun ^a,b,c   Zhou, Hongyan ^a,b,c   Huang, Xiangkun ^a,b,c   Zhu, Lianxiang ^a,b,c   Kijlstra, Aize ^d  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Endotoxin induceduveitis; LPS; T bet; Th1 cells

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; MESSENGER RNA; TRANSCRIPTION FACTOR T BET;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE SEVERITY; EYE INFLAMMATION; FOOT PAD; FROZEN SECTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IRIS; MALE; NICK END LABELING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; SLIT LAMP; SPLEEN; UVEITIS;

ANIMALS; APOPTOSIS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; IRIS; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALMONELLA TYPHIMURIUM; SPLEEN; T-BOX DOMAIN PROTEINS; UVEITIS;

EID: 33947176698     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-006-0385-4     Document Type: Article

References (33)

1. Bhattacherjee P, Williams RN, Eakins KE (1983) An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat footpad. Invest Ophthalmol Vis Sci 24:196-202
2. De Vos AF, Klaren VN, Kijlstra A (1994) Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis Sci 35:3873-3883
3. Finotto S, Neurath MF, Glichman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH (2002) Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295:336-338
4. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM (2001) Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14:205-215
5. Hoekzema R, Verhagen C, Van Haren M, Kijlstra A (1992) Endotoxin-induced uveitis in the rat. The significance of intraocular interleukin 6. Invest Ophthalmol Vis Sci 33:532-539
6. Kogiso M, Tanouchi Y, Mimura Y, Nagasawa H, Himeno K (1992) Endotoxin-induced uveitis in mice. I. Induction of uveitis and role of T lymphocytes. Jpn J Ophthamol 36:281-290
7. Kozhich AT, Chan CC, Gery I, Whitcup SM (2000) Recurrent intraocular inflammation in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 41:1823-1826
8. Li B, Yang P, Zhou H, Zhang Z, Xie C, Lin X, Huang X, Kijlstra A (2003) T-bet expression is upregulated in active Behcet's disease. Br J Ophthalmol 87:1264-1267
9. Li B, Yang P, Zhou H, Huang X, Jin H, Chu L, Gao Y, Zhu L, Kijlstra A (2005) Upregulation of T-bet expression in peripheral blood mononuclear cells during Vogt-Koyanagi-Harada disease. Br J Ophthalmol 89:1410-1412
10. Lighvani AA, Frucht DM, Jankovic D, Yamane H, Aliberti J, Hissong BD, Nguyen BV, Gadina M, Sher A, Paul WE, O'Shea JJ (2001) T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci USA 98:15137-15142
11. McMenamin PG, Crewe J (1995) Endotoxin-induced uveitis: Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol Vis Sci 36:1949-1959
12. McMenamin PG, Crewe J, Morrison S, Holt PG (1994) Immunomorphologic studies of macrophage and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse and human eye. Invest Ophthalmol Vis Sci 35:3234-3250
13. Mosmann TR, Sad S (1996) The expanding universe of T cell subsets: Th1, Th2 and more. Immunol Today 17:138-146 138-146
14. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL (2001) Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292:1907-1910 1907-1910
15. Neurath MF, Weigmann B, Finotto S, Glickman J, Nieuwenhuis E, Iijima H, Mizoguchi A, Mizoguchi E, Mudter J, Galle PR, Bhan A, Autschbach F, Sullivan BM, Szabo SJ, Glimcher LH, Blumberg RS (2002) The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 195:1129-1143
16. Ohta K, Wiggert B, Taylor AW, Streilein JW (1999) Effects of experimental ocular inflammation on ocular immune privilege. Invest Ophthalmol Vis Sci 40:2010-2018
17. Okumura A, Mochizuki M (1988) Endotoxin-induced uveitis in rats: morphological and biochemical study. Jpn J Ophthalmol 32:457-465
18. Papaioannou VE (2001) T-box genes in development: From hydra to humans. Int Rev Cytol 207:1-70
19. Paul WE, Seder RA (1994) Lymphocyte responses and cytokines. Cell 76:241-251
20. Planck SR, Huang XN, Robertson JE, Rosenbaum JT (1994) Cytokine mRNA levels in rat ocular tissues after systemic endotoxin treatment. Invest Ophthalmol Vis Sci 35:924-930
21. Romagnani S (1997) The Th1/Th2 paradigm. Immunol Today 18:263-266
22. Rosenbaum JT (1984) Endotoxin-induced uveitis. In: Tabarra KF (ed) Animal models of ocular disease. Thomas, Springfield, IL, pp 247-253
23. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR (1980) Endotoxin-induced uveitis in rats as a model for human disease. Nature 286:611-613
24. Ruiz-Moreno JM, Thillaye B, de Kozak Y (1992) Rentino-choroidal changes in endotoxin-induced uveitis in the rat. Ophthalmic Res 24:162-168
25. Salvati VM, MacDonald TT, Bajaj-Elliott M, Borrelli M, Staiano A, Auricchio S, Troncone R, Monteleone G (2002) Interleukin-18 and associated markers of T helper cell type I activity in coeliac disease. Gut 50:186-190
26. Shen DF, Chang MA, Matteson DM, Buggage R, Kozhich AT, Chan CC (2000) Biphasic ocular inflammatory response to endotoxin-induced uveitis in the mouse. Arch Ophthalmol 118:521-527
27. Smith JR, Hart PH, Standfield SD, Coster DJ, Wing SJ, Williams KA (2000) Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat. Br J Ophthalmol 84:205-211
28. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:609-655
29. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH (2002) Distinct effects of T-bet in Th1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295:338-342
30. Yang P, de Vos AF, Kijlstra A (1996) Macrophages in the retina of normal Lewis rats and their dynamic after injection of lipopolysaccharide. Invest Ophthalmol Vis Sci 37:77-85
31. Yang P, de Vos AF, Kijlstra A (1997) Macrophages and MHC class II positive cells in the choroid during endotoxin-induced uveitis. Br J Ophthalmol 81:396-401
32. Yang P, de Vos AF, Kijlstra A (1998) Interferon-gamma immunoreactivity in iris nerve fibres during endotoxin induced uveitis in the rat. Br J Ophthalmol 82:695-699
33. Yang P, Smith JR, Damodar KS, Planck SR, Rosenbaum JT (2003) Visualization of cell death in vivo during murine endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 44:1993-1997