Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma

Critical Care Medicine

Volumn 35, Issue 3, 2007, Pages 919-924

  Kline, Anthony E ^a,b,c   Massucci, Jaime L ^a,b,c   Zafonte, Ross D ^a   Dixon, C Edward ^a,b,c   DeFeo, Judith R ^a   Rogers, Emily H ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Beam balance; Catecholamines; Cognition; Controlled cortical impact; Functional recovery; Morris water maze; Traumatic brain injury

Indexed keywords

HALOPERIDOL; RISPERIDONE;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFICACY; MALE; MAZE TEST; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RAT; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANIMALS; ANTIPSYCHOTIC AGENTS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ESCAPE REACTION; HALOPERIDOL; HEAD INJURIES, CLOSED; INJECTIONS, INTRAPERITONEAL; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; MOTOR SKILLS; MUSCULOSKELETAL EQUILIBRIUM; NEUROLOGIC EXAMINATION; ORIENTATION; RATS; RATS, SPRAGUE-DAWLEY; RISPERIDONE;

EID: 33947158839     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000256722.88854.C0     Document Type: Article

References (39)

1. Dunn-Meynell A, Pan S, Levin BE: Focal traumatic brain injury causes widespread reductions in rat brain norepinephrine turnover from 6 to 24 h. Brain Res 1994; 660:88-95
2. Feeney DM, Weisend MP, Kline AE: Noradrenergic pharmacotherapy, intracerebral infusion and adrenal transplantation promote functional recovery after cortical damage. J Neural Transplant Plast 1993; 4:199-213
3. Huger F, Patrick G: Effect of concussive head injury on central catecholamine levels and synthesis rates in rat brain regions. J Neurochem 1979; 33:89-95
4. Massucci JL, Kline AE, Ma X, et al: Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats. Neurosci Lett 2004; 372:127-131
5. McIntosh TK, Yu T, Gennarelli TA: Alterations in regional brain catecholamine concentrations after experimental brain injury in the rat. J Neurochem 1994; 63:1426-1433
6. Feeney DM: From laboratory to clinic: Noradrenergic enhancement of physical therapy for stroke or trauma patients. Adv Neurol 1997; 73:383-394
7. Hamm RJ, Dixon CE, Gbadebo DM, et al: Cognitive deficits following traumatic brain injury produced by controlled cortical impact. J Neurotrauma 1992; 9:11-20
8. Kline AE, Massucci JL, Dixon CE, et al: The therapeutic efficacy conferred by the 5-HT(1A) receptor agonist 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) after experimental traumatic brain injury is not mediated by concomitant hypothermia. J Neurotrauma 2004; 21:175-185
9. Kline AE, Massucci JL, Ma X, et al: Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma. J Neurotrauma 2004; 21:1712-1722
10. Kline AE, Massucci JL, Marion DW, et al: Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact. J Neurotrauma 2002; 19:415-425
11. Kline AE, Yan HQ, Bao J, et al: Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats. Neurosci Lett 2000; 280:163-166
12. Wagner AK, Sokoloski JE, Ren D, et al: Controlled cortical impact injury affects dopaminergic transmission in the rat striatum. J Neurochem 2005; 95:457-465
13. Wilson MS, Chen X, Ma X, et al: Synaptosomal dopamine uptake in rat striatum following controlled cortical impact. J Neurosci Res 2005; 80:85-91
14. Yan HQ, Kline AE, Ma X, et al: Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury. Neuroreport 2001; 12:2323-2327
15. Yan HQ, Kline AE, Ma X, et al: Traumatic brain injury reduces dopamine transporter protein expression in the rat frontal cortex. Neuroreport 2002; 13:1899-1901
16. Dixon CE, Kraus MF, Kline AE, et al: Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats. Restor Neurol Neurosci 1999; 14:285-294
17. Kline AE, Chen MJ, Tso-Olivas DY, et al: Methylphenidate treatment following ablation-induced hemiplegia in rat: Experience during drug action alters effects on recovery of function. Pharmacol Biochem Behav 1994; 48:773-779
18. Kraus MF, Maki PM: Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: Case studies and review. J Neuropsychiatry Clin Neurosci 1997; 9:222-320
19. McDowell S, Whyte J, D'Esposito M: Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients. Brain 1998; 121:1155-1164
20. Plenger PM, Dixon CE, Castillo RM, et al: Subacute methylphenidate treatment for moderate to moderately severe traumatic brain injury: A preliminary double-blind placebo-controlled study. Arch Phys Med Rehabil 1996; 77:536-540
21. Whyte J, Hart T, Schuster K, et al: Effects of methylphenidate on attentional function after traumatic brain injury: A randomized, placebo-controlled trial. Am J Phys Med Rehabil 1997; 76:440-450
22. Parton A, Coulthard E, Husain M: Neuropharmacological modulation of cognitive deficits after brain damage. Curr Opin Neurol 2005; 18:675-680
23. Elovic EP, Lansang R, Li Y, et al: The use of atypical antipsychotics in traumatic brain injury. J Head Trauma Rehabil 2003; 18:177-195
24. Levy M, Berson A, Cook T, et al: Treatment of agitation following traumatic brain injury: A review of the literature. NeuroRehabilitation 2005; 20:279-306
25. Lombard LA, Zafonte RD: Agitation after traumatic brain injury: Considerations and treatment options. Am J Phys Med Rehabil 2005; 84:797-812
26. Feeney DM, Gonzalez A, Law WA: Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 1982; 217:855-857
27. Goldstein LB, Bullman S: Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats. Neurorehabil Neural Repair 2002; 16:1-5
28. Feeney DM, Westerberg VS: Norepinephrine and brain damage: Alpha noradrenergic pharmacology alters functional recovery after cortical trauma. Can J Psychol 1990; 44:233-252
29. Wilson MS, Gibson CJ, Hamm RJ: Haloperidol, but not olanzapine, impairs cognitive performance after traumatic brain injury in rats. Am J Phys Med Rehabil 2003; 82:871-879
30. Kline AE, Dixon CE: Contemporary in vivo models of brain trauma and a comparison of injury responses. In: Head Trauma: Basic, Preclinical and Clinical Directions. Miller LP, Hayes RL (Eds). New York, John Wiley and Sons, 2001, 65-84
31. Rosengarten H, Quartermain D: The effect of chronic treatment with typical and atypical antipsychotics on working memory and jaw movements in three-and eighteen-month-old rats. Prog Neuropsychopharmacol Biol Psychiatry 2002; 26:1047-1054
32. Alleva E, Della-Seta D, Cirulli F, et al: Haloperidol treatment decreases nerve growth factor levels in the hypothalamus of adult mice. Prog Neuropsychopharmacol Biol Psychiatry 1996; 20:483-489
33. Feeney DM, De Smet AM, Rai S: Noradrenergic modulation of hemiplegia: Facilitation and maintenance of recovery. Restor Neurol Neurosci 2004; 22:175-190
34. Goldstein LB: Common drugs may influence motor recovery after stroke: The Sygen in Acute Stroke Study Investigators. Neurology 1995; 45:865-871
35. Schotte A, Janssen PF, Megens AA, et al: Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain Res 1993; 631:191-202
36. Feeney DM, Sutton RL: Pharmacotherapy for recovery of function after brain injury. Crit Rev Neurobiol 1987; 3:135-197
37. Phillips JP, Devier DJ, Feeney DM: Rehabilitation pharmacology: Bridging laboratory work to clinical application. J Head Trauma Rehabil 2003; 18:342-356
38. Meneses A: 5-HT system and cognition. Neurosci Biobehav Rev 1999; 23:1111-1125
39. Meneses A, Hong E: Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in learning. Behav Brain Res 1997; 87:105-110