Haloperidol, but Not Olanzapine, Impairs Cognitive Performance After Traumatic Brain Injury in Rats

American Journal of Physical Medicine and Rehabilitation

Volumn 82, Issue 11, 2003, Pages 871-879

  Wilson, Margaret S ^a   Gibson, Cynthia J ^b   Hamm, Robert J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY   (United States)

Author keywords

Antipsychotic Agents; D2 like dopamine receptors; Dopamine; Haloperidol; Olanzapine; Traumatic Brain Injury

Indexed keywords

BRAIN; DRUG PRODUCTS; PATHOLOGY; PATIENT TREATMENT;

BRAIN INJURY;

PATIENT REHABILITATION;

DOPAMINE 2 RECEPTOR; DRUG VEHICLE; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE;

AGGRESSION; AGITATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN INJURY; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; MALE; MAZE TEST; MOOD DISORDER; NONHUMAN; PERSONALITY DISORDER; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BRAIN INJURIES; COGNITION DISORDERS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; INJECTIONS, INTRAPERITONEAL; MALE; MAZE LEARNING; PIRENZEPINE; RATS; RATS, SPRAGUE-DAWLEY; SWIMMING;

EID: 0142213178     PISSN: 08949115     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PHM.0000091982.33232.CB     Document Type: Article

References (20)

1. Capruso DX, Levin HS: Cognitive impairment following closed head injury. Neurol Clin 1992;10:879-93
2. Wroblewski BA, Guidos A, Leary J, et al: Control of depression with fluoxetine and antiseizure medication in a brain-injured patient. Am J Psychiatry 1992;149:273
3. Stanislav SW: Cognitive effects of antipsychotic agents in persons with traumatic brain injury. Brain Inj 1997;11:335-41
4. Feeney DM, Gonzalez A, Law WA: Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 1982;217:855-7
5. Feeney DM, Hovda DA: Amphetamine and apomorphine restore tactile placing after motor cortex injury in the cat. Psychopharmacology (Berl) 1983;79:67-71
6. Zhu J, Hamm RJ, Reeves TM, et al: Postinjury administration of L-deprenyl improves cognitive function and enhances neuroplasticity after traumatic brain injury. Exp Neurol 2000;166:136-52
7. Kline AE, Massucci JL, Marion DW, et al: Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact. J Neurotrauma 2002;19:415-25
8. McDowell S, Whyte J, D'Esposito M: Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients. Brain 1998;121(pt 6):1155-64
9. Fowler SB, Hertzog J, Wagner BK: Pharmacological interventions for agitation in head-injured patients in the acute care setting. J Neurosci Nurs 1995;27:119-23
10. Ploeger GE, Spruijt BM, Cools AR: Spatial localization in the Morris water maze in rats: Acquisition is affected by intra-accumbens injections of the dopaminergic antagonist haloperidol. Behav Neurosci 1994;108:927-34
11. Terry AV Jr, Hill WD, Parikh V, et al: Differential effects of chronic haloperidol and olanzapine exposure on brain cholinergic markers and spatial learning in rats. Psychopharmacology (Berl) 2002;164:360-8
12. Maguire GA: Comprehensive understanding of schizophrenia and its treatment. Am J Health Syst Pharm 2002;59(17 suppl 5):S4-11
13. Andersson C, Hamer RM, Lawler CP, et al: Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs. Neuropsychopharmacology 2002;27:143-51
14. Bai O, Chlan-Fourney J, Bowen R, et al: Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J Neurosci Res 2003;71:127-31
15. McIntosh TK, Vink R, Noble L, et al: Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model. Neuroscience 1989;28:233-44
16. Dixon CE, Kraus MF, Kline AE, et al: Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats. Restorative Neurol Neurosci 1999;14:285-94
17. Wilkinson R, Meythaler JM, Guin-Renfroe S: Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. Brain Inj 1999;13:1025-31
18. Vincent FM, Zimmerman JE, Van Haren J: Neuroleptic malignant syndrome complicating closed head injury. Neurosurgery 1986;18:190-3
19. Bascunana H, Villarreal I, Alfonso S, et al: [Agitation in head injury: I. Definition and treatment with anxiolytic neuroleptics and antiepileptic drugs.] Rev Neurol 2000;30:850-4
20. Fava M: Psychopharmacologic treatment of pathologic aggression. Psychiatr Clin North Am 1997;20:427-51