Tumor suppressors in hepatocellular carcinoma: Many are called, but few are chosen

Journal of Hepatology

Volumn 46, Issue 4, 2007, Pages 546-548

  Buendia, Marie Annick ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 6; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; CANCER INHIBITION; CARCINOGENESIS; CELL ONCOGENE; CELL PROLIFERATION; CHROMOSOME ABERRATION; CHRONIC LIVER DISEASE; EDITORIAL; GENE EXPRESSION; HEPATITIS B VIRUS; HETEROZYGOSITY LOSS; HUMAN; LIVER CELL CARCINOMA; LIVER FUNCTION; MUTATION; PRIORITY JOURNAL; SOLID TUMOR; TUMOR GENE; TUMOR RECURRENCE; TUMOR SUPPRESSOR GENE;

CARCINOMA, HEPATOCELLULAR; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HEPATITIS C; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS;

EID: 33947156361     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.01.005     Document Type: Editorial

References (32)

1. El-Serag H.B. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 127 (2004) S27-S34
2. Parkin D.M. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118 (2006) 3030-3044
3. Bruix J., Boix L., Sala M., and Llovet J.M. Focus on hepatocellular carcinoma. Cancer Cell 5 (2004) 215-219
4. Bruix J., Hessheimer A.J., Forner A., Boix L., Vilana R., and Llovet J.M. New aspects of diagnosis and therapy of hepatocellular carcinoma. Oncogene 25 (2006) 3848-3856
5. Avila M.A., Berasain C., Sangro B., and Prieto J. New therapies for hepatocellular carcinoma. Oncogene 25 (2006) 3866-3884
6. Buendia M.A. Genetics of hepatocellular carcinoma. Semin Cancer Biol 10 (2000) 185-200
7. Laurent-Puig P., and Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene 25 (2006) 3778-3786
8. Lee J.S., and Thorgeirsson S.S. Comparative and integrative functional genomics of HCC. Oncogene 25 (2006) 3801-3809
9. Breuhahn K., Longerich T., and Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 25 (2006) 3787-3800
10. Zucman-Rossi J, Benhamouche S, Godard C, Boyault S, Grimber G, Balabaud C, et al. Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. Oncogene 2007, in press.
11. Bluteau O., Jeannot E., Bioulac-Sage P., Marques J.M., Blanc J.F., Bui H., et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet 32 (2002) 312-315
12. Calvisi D.F., Ladu S., Gorden A., Farina M., Conner E.A., Lee J.S., et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 130 (2006) 1117-1128
13. Pineau P., Marchio A., Nagamori S., Seki S., Tiollais P., and Dejean A. Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. Hepatology 37 (2003) 852-861
14. Murakami Y., Saigo K., Takashima H., Minami M., Okanoue T., Brechot C., et al. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 54 (2005) 1162-1168
15. Kremer-Tal S., Narla G., Chen Y., Hod E., DiFeo A., Yea S., et al. Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J Hepatol 46 (2007) 645-654
16. Narla G., Heath K.E., Reeves H.L., Li D., Giono L.E., Kimmelman A.C., et al. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science 294 (2001) 2563-2566
17. Kremer-Tal S., Reeves H.L., Narla G., Thung S.N., Schwartz M., Difeo A., et al. Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. Hepatology 40 (2004) 1047-1052
18. Boyault S., Herault A., Balabaud C., and Zucman-Rossi J. Absence of KLF6 gene mutation in 71 hepatocellular carcinomas. Hepatology 41 (2005) 681-682 author reply 682-683
19. Song J., Kim C.J., Cho Y.G., Kim S.Y., Nam S.W., Lee S.H., et al. Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma. J Gastroenterol Hepatol 21 (2006) 1286-1289
20. Ito G., Uchiyama M., Kondo M., Mori S., Usami N., Maeda O., et al. Kruppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Cancer Res 64 (2004) 3838-3843
21. Ratziu V., Lalazar A., Wong L., Dang Q., Collins C., Shaulian E., et al. Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci USA 95 (1998) 9500-9505
22. Starkel P., Sempoux C., Leclercq I., Herin M., Deby C., Desager J.P., et al. Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. J Hepatol 39 (2003) 538-546
23. Botella L.M., Sanchez-Elsner T., Sanz-Rodriguez F., Kojima S., Shimada J., Guerrero-Esteo M., et al. Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. Blood 100 (2002) 4001-4010
24. Kojima S., Hayashi S., Shimokado K., Suzuki Y., Shimada J., Crippa M.P., et al. Transcriptional activation of urokinase by the Kruppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells. Blood 95 (2000) 1309-1316
25. Warke V.G., Nambiar M.P., Krishnan S., Tenbrock K., Geller D.A., Koritschoner N.P., et al. Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. J Biol Chem 278 (2003) 14812-14819
26. DiFeo A., Narla G., Camacho-Vanegas O., Nishio H., Rose S.L., Buller R.E., et al. E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor. Oncogene 25 (2006) 6026-6031
27. Li D., Yea S., Li S., Chen Z., Narla G., Banck M., et al. Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J Biol Chem 280 (2005) 26941-26952
28. Das A., Fernandez-Zapico M.E., Cao S., Yao J., Fiorucci S., Hebbel R.P., et al. Disruption of an SP2/KLF6 repression complex by SHP is required for Farnesoid X receptor-induced endothelial cell migration. J Biol Chem (2006)
29. Slavin D.A., Koritschoner N.P., Prieto C.C., Lopez-Diaz F.J., Chatton B., and Bocco J.L. A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function. Oncogene 23 (2004) 8196-8205
30. Narla G., Difeo A., Reeves H.L., Schaid D.J., Hirshfeld J., Hod E., et al. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Res 65 (2005) 1213-1222
31. Narla G., DiFeo A., Yao S., Banno A., Hod E., Reeves H.L., et al. Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread. Cancer Res 65 (2005) 5761-5768
32. Martin-Caballero J., Flores J.M., Garcia-Palencia P., and Serrano M. Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. Cancer Res 61 (2001) 6234-6238