Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa

Molecular Immunology

Volumn 44, Issue 11, 2007, Pages 3037-3048

  Dobano C ^a,b   Doolan, D L ^a,c  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

CD4+ T cells; CD8+; Epitope mapping; Immunization; Peptides; Plasmodium yoelii; PyHEP17

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DNA BINDING; EPITOPE MAPPING; ERYTHROCYTE; FEMALE; IMMUNE RESPONSE; LIVER CELL; LYMPHOCYTE PROLIFERATION; MALARIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PLASMODIUM BERGHEI; PRIORITY JOURNAL; SPOROZOITE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; MALARIA; MALARIA VACCINES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PROTOZOAN PROTEINS;

MUS; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII;

EID: 33947151945     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.01.001     Document Type: Article

References (22)

1. Brice G.T., Graber N.L., Carucci D.J., and Doolan D.L. Optimal induction of antigen-specific CD8+ T cell responses requires bystander cell participation. J. Leukoc. Biol. 72 (2002) 1164-1171
2. Charoenvit Y., Leef M.F., Yuan L.F., Sedegah M., and Beaudoin R.L. Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens. Infect. Immun. 55 (1987) 604-608
3. Charoenvit Y., Majam Fallarme V., Corradin G., Sacci Jr. J.B., Wang R., Doolan D.L., Jones T.R., Abot E., Patarroyo M.E., Guzman F., and Hoffman S.L. CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein. Infect. Immun. 67 (1999) 5604-5614
4. Charoenvit Y., Mellouk S., Sedegah M., Toyoshima T., Leef M.F., De la Vega P., Beaudoin R.L., Aikawa M., Fallarme V., and Hoffman S.L. Plasmodium yoelii: 17-kDa hepatic and erythrocytic stage protein is the target of an inhibitory monoclonal antibody. Exp. Parasitol. 80 (1995) 419-429
5. Del Giudice G., Grillot D., Renia L., Muller I., Corradin G., Louis J.A., Mazier D., and Lambert P.H. Peptide-primed CD4+ cells and malaria sporozoites. Immunol. Lett. 25 (1990) 59-63
6. Doolan D.L., Hedstrom R.C., Rogers W.O., Charoenvit Y., Rogers M., De la Vega P., and Hoffman S.L. Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1. J. Biol. Chem. 271 (1996) 17861-17868
7. Doolan D.L., Sedegah M., Hedstrom R.C., Hobart P., Charoenvit Y., and Hoffman S.L. Circumventing genetic restriction of protection against malaria with multi-gene DNA immunization: CD8+ T cell, interferon-γ, and nitric oxide dependent immunity. J. Exp. Med. 183 (1996) 1739-1746
8. Franke E.D., Corradin G., and Hoffman S.L. Induction of protective CTL responses against the Plasmodium yoelii circumsporozoite protein by immunization with peptides. J. Immunol. 159 (1997) 3424-3433
9. Hartikka J., Sawdey M., Cornefert-Jensen F., Margalith M., Barnhart K., Nolasco M., Vahlsing H.L., Meek J., Marquet M., Hobart P., Norman J., and Manthorpe M. An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum. Gene Ther. 7 (1996) 1205-1217
10. Hoffman S.L., Goh L.M., Luke T.C., Schneider I., Le T.P., Doolan D.L., Sacci J., de La Vega P., Dowler M., Paul C., Gordon D.M., Stoute J.A., Church L.W., Sedegah M., Heppner D.G., Ballou W.R., and Richie T.L. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 185 (2002) 1155-1164
11. Lal A.A., de la Cruz V.F., Welsh J.A., Charoenvit Y., Maloy W.L., and McCutchan T.F. Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. A rodent model for examining antimalarial sporozoite vaccines. J. Biol. Chem. 262 (1987) 2937-2940
12. Luke C.J., Carner K., Liang X., and Barbour A.G. An OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi. J. Infect. Dis. 175 (1997) 91-97
13. Narum D.L., Kumar S., Rogers W.O., Fuhrmann S.R., Liang H., Oakley M., Taye A., Sim B.K., and Hoffman S.L. Codon optimization of gene fragments encoding Plasmodium falciparum merzoite proteins enhances DNA vaccine protein expression and immunogenicity in mice. Infect. Immun. 69 (2001) 7250-7253
14. Nussenzweig V., and Nussenzweig R.S. Circumsporozoite proteins of malaria parasites. Bull. Mem. Acad. R. Med. Belg. 144 (1989) 493-504
15. Renia L., Marussig M.S., Grillot D., Pied S., Corradin G., Miltgen F., Del Giudice G., and Mazier D. In vitro activity of CD4+ and CD8+ T lymphocytes from mice immunized with a synthetic malaria peptide. Proc. Natl. Acad. Sci. USA 88 (1991) 7963-7967
16. Sedegah M., Hedstrom R., Hobart P., and Hoffman S.L. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. USA 91 (1994) 9866-9870
17. Simmons D., Woollet G., Bergin-Cartwright M., Kay D., and Scaife J. A malaria protein exported into a new compartment within the host erytrocyte. EMBO J. 6 (1987) 485-491
18. Valmori D., Romero J.F., Men Y., Maryanski J.L., Romero P., and Corradin G. Induction of a cytotoxic T cell response by co-injection of a T helper peptide and a cytotoxic T lymphocyte peptide in incomplete Freund's adjuvant (IFA): further enhancement by pre-injection of IFA alone. Eur. J. Immunol. 24 (1994) 1458-1462
19. Wang R., Epstein J., Baraceros F.M., Gorak E.J., Charoenvit Y., Carucci D.J., Hedstrom R.C., Rahardjo N., Gay T., Hobart P., Stout R., Jones T.R., Richie T.L., Parker S.E., Doolan D.L., Norman J., and Hoffman S.L. Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine. Proc. Natl. Acad. Sci. USA 98 (2001) 10817-10822 Epub 2001 Aug 28
20. Weiss W.R., Berzovsky J.A., Houghten R.A., Sedegah M., Hollingdale M., and Hoffman S.L. A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei. J. Immunol. 149 (1992) 2103-2109
21. Weiss W.R., Ishii K.J., Hedstrom R.C., Sedegah M., Ichino M., Barnhart K., Klinman D.M., and Hoffman S.L. A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J. Immunol. 161 (1998) 2325-2332
22. Weiss W.R., Sedegah M., Beaudoin R.L., Miller L.H., and Good M.F. CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc. Natl. Acad. Sci. USA 85 (1988) 573-576