Use of a Mycobacterial Cell Wall Extract (MCWE) in Susceptible Mares to Clear Experimentally Induced Endometritis With Streptococcus zooepidemicus

Journal of Equine Veterinary Science

Volumn 27, Issue 3, 2007, Pages 112-117

  Rogan, D ^a   Fumuso, E ^b   Rodriguez E ^b   Wade, J ^c   Bruni, S F Sánchez ^b,d  

^a Bioniche Animal Health   (Canada)

^b UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

^c Bioniche Animal Health (Europe)   (Ireland)

^d Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Endometritis; Immunomodulation; Innate immunity; Mares; Mycobacterial cell wall extract (MCWE)

Indexed keywords

STREPTOCOCCUS EQUI SUBSP. ZOOEPIDEMICUS;

EID: 33947151453     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2007.01.010     Document Type: Article

References (40)

1. Troedsson M.H.T. Uterine clearance and resistance to persistent endometritis in the mare. Theriogenology 52 (1999) 461-471
2. Watson E.D. Post breeding endometritis in the mare. Anim Reprod Sci 60-61 (2000) 221-232
3. Hughes JP, Loy RG. Investigations of the effect of intrauterine innoculation of Streptococcus zooepidemicus in the mare. In: Proceedings 15th Annual Convention of the American Association of Equine Practitioners; 1969:285-289.
4. Waelchli R.O., and Winder N.C. Mononuclear cell infiltration of the equine endometrium: immunohistochemical studies. Equine Vet J 23 (1991) 470-474
5. Troedsson M.H., Liu I.K., and Thurmond M. Function of uterine and blood-derived polymorphonuclear neutrophils in mares susceptible and resistant to chronic uterine infection: phagocytosis and chemotaxis. Biol Reprod 49 (1993) 507-514
6. Watson E.D., Stokes C.R., and Bourne F.J. Cellular and humoral defence mechanisms in mares susceptible and resistant to persistent endometritis. Vet Immunol Immunopathol 16 (1987) 107-121
7. Cheung A.T., Liu I.K., Walsh E.M., and Miller M.E. Phagocytic and killing capacities of uterine-derived polymorphonuclear leukocytes from mares resistant and susceptible to chronic endometritis. Am J Vet Res 46 (1985) 1938-1940
8. Liu I.K., Cheung A.T., Walsh E.M., Miller M.E., and Lindenberg P.M. Comparison of peripheral blood and uterine-derived polymorphonuclear leukocytes from mares resistant and susceptible to chronic endometritis: chemotactic and cell elastimetry analysis. Am J Vet Res 46 (1985) 917-920
9. Couto M.A., and Hughes J.P. Intrauterine inoculation of a bacteria-free filtrate of Streptococcus zooepidemicus in clinically normal and infected mares. J Equine Vet Sci 5 (1985) 81-86
10. Zerbe H., Schuberth H.J., Engelke F., Frank J., Klug E., and Leibold W. Development and comparison of in vivo and in vitro models for endometritis in cows and mares. Theriogenology 60 (2003) 209-223
11. LeBlanc M., Neuwirth L., Mauragis D., Klapstein E., and Tran T. Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis. Equine Vet J 26 (1994) 279-282
12. LeBlanc M. Oxytocin: the new wonder drug for treatment of endometritis. Equine Vet Educ 6 (1994) 39-43
13. Fumuso E., Giguère S., Wade J., Rogan D., Videla-Dorna I., and Bowden R. Endometrial IL-1beta, IL-6 and TNF-alpha, mRNA expression in mares resistant or susceptible to post-breeding endometritis: effects of estrous cycle, artificial insemination and immunomodulation. Vet Immunol Immunopathol 96 (2003) 31-41
14. Fumuso E, Álvarez G, Bruno S, Videla-Dorna I, Wade J, Rogan D, et al. Non-specific immunomodulation at post-partum improves uterine condition and fertility in mares. In: Proceedings 8th World Equine Veterinary Association, Buenos Aires, Argentina; 2003:80.
15. Fumuso E, Aguilar J, Giguère S, Videla Dorna I, Wade J, Rogan D. Non-specific immunomodulation (NSI) can rectify an imbalanced uterine/ovarian milieu in mares susceptible to endometritis. In: Proceedings 6th International Symposium on Equine Embryo Transfer, Rio de Janeiro, Brazil; Havermeyer Foundation Monograph Series (ISSN 1472-3158) No. 14: 2004a:10-12.
16. Fumuso E, Demarchi E, González F, Rodriguez E, Videla Dorna I, Wade J, et al. Non-specific immuno-modulation improves fertility in sub-fertile mares. In: Proceedings 15th International Congress on Animal Reproduction (ICAR), Porto Seguro, Brazil; 2004b:247.
17. Rogan D, Fumuso E, Wade J, Sanchez Bruni SF. Immunotherapeutic activity of a mycobacterial cell wall formulation in treating Streptococcus zooepidemicus induced endometritis in mares. In: Proceedings Modern Vaccine/Adjuvant Formulation, Prague, Czech Republic; 2004: Proc. on CD, Index.html:8.
18. Rogan D, Strauss C. Potential use of immunomodulation in the treatment of endometritis in cattle. In: Proceedings 6° Simposio Internacional de Reproduccion Animale, Cordoba, Argentina; 2005:259-275.
19. Brinsko S, Rigby SL, Varner DD, Blanchard TL. A practical method for recognizing mares susceptible to post-breeding endometritis. In: Proceedings 49th Annual Convention of the American Association of Equine Practitioners, New Orleans, Louisiana. Ithaca: International Veterinary Information Service (www.ivis.org), 2003; Document No. P0657.1103.
20. Losinno L., and Aguilar J. Ultrasonografía aplicada a la reproducción en la yegua. Rev Col Cienc Pec 13 (2000) 60-71
21. Cadario M.E., Thatcher W.W., Klapstein E., Merrit A.M., Archbald L.F., Thatcher M.J., et al. Dynamics of prostaglandin secretion, intrauterine fluid and uterine clearance in reproductively normal mares and mares with delayed uterine clearance. Theriogenology 52 (1999) 1181-1192
22. Ricketts S.W. The barren mare. In Practice 11 (1989) 119-123
23. Ricketts S.W. The barren mare. In Practice 11 (1989) 156-164
24. st Annual Convention of the American Association of Equine Practitioners, Seattle, WA. Ithaca: International Veterinary Information Service (www.ivis.org), 2005; Document No. P2630.1205.
25. Miragaya M.H., Woods G.L., and Losinno L. Endometritis, salpingitis and fertilisation rates after mating mares with a history of intrauterine lumenal fluid accumulation. Equine Vet J 25 suppl. (1997) 109-112
26. Yamamura Y., Sakatani M., Ogura T., and Azuma I. Adjuvant immunotherapy of lung cancer with BCG cell wall skeleton (BCG-CWS). Cancer 43 (1979) 1314-1319
27. Azuma I., Ribi E.E., Meyer T.J., and Zbar B. Biologically active components from mycobacterial cell walls. I. Isolation and composition of cell wall skeleton and component P3. J Natl Cancer Inst 52 (1974) 95-101
28. Adam A., and Lederer E. Muramyl peptides: immunomodulators, sleep factors, and vitamins. Med Res Rev 4 (1984) 111-152
29. Azuma I., and Seya T. Development of immunoadjuvants for immunotherapy of cancer. Int Immunopharmacol 1 (2001) 1249-1259
30. Korf J., Stoltz A., Verschoor J., De Baetselier P., and Grooten J. The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses. Eur J Immunol 35 (2005) 890-900
31. Indrigo J., Hunter Jr. R.L., and Actor J.K. Cord factor trehalose 6,6′-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology 149 (2003) 2049-2059
32. Gobec S., Plantan I., Mravljak J., Wilson R.A., Besra G.S., and Kikelj D. Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall. Bioorg Med Chem Lett 4 (2004) 3559-3562
33. Strohmeier G.R., and Fenton M.J. Roles of lipoarabinomannan in the pathogenesis of tuberculosis. Microbes Infect 1 (1999) 709-717
34. Means T.K., Jones B.W., Schromm A.B., Shurtleff B.A., Smith J.A., Keane J., et al. Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses. J Immunol 166 (2001) 4074-4082
35. Velasco-Velazquez M.A., Barrera D., Gonzalez-Arenas A., Rosales C., and Agramonte-Hevia J. Macrophage-Mycobacterium tuberculosis interactions: role of complement receptor 3. Microb Pathog 35 (2003) 125-131
36. Klucinski W., Dembele K., Kleczkowski M., Sitarska E., Winnicka A., and Sikora J. Evaluation of the effect of experimental cow endometritis on bactericidal capability of phagocytizing cells isolated from the blood and uterine lumen. Zentralbl Veterinarmed A 42 (1995) 461-466
37. Colotta F., Re F., Polentarutti N., Sozzani S., and Mantovani A. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80 (1992) 2012-2020
38. Singh J., Sidhu S.S., Dhaliwal G.S., Pangaonkar G.R., Nanda A.S., and Grewal A.S. Effectiveness of lipopolysaccharide as an intrauterine immunomodulator in curing bacterial endometritis in repeat breeding cross-bred cows. Anim Reprod Sci 59 (2000) 159-166
39. Neufert C., Pai R.K., Noss E.H., Berger M., Boom W.H., and Harding C.V. Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation. J Immunol 167 (2001) 1542-1549
40. LeBlanc MM. Persistent mating induced endometritis in the mare: pathogenesis, diagnosis and treatment. In: Ball BA, ed. Recent advances in equine reproduction. Ithaca: International Veterinary Information Service (www.ivis.org), 2003; Document No. A0206.1203.