Significant impact of MTHFR C677T polymorphism on plasma homovanillic acid (HVA) levels among alcohol-dependent patients

Addiction Biology

Volumn 12, Issue 1, 2007, Pages 100-105

  Lutz, Ulrich C ^a   Batra, Anil ^a   Wiatr, Gerlinde ^a   MacHicao, Fausto ^a   Kolb, Werner ^b   Maurer, Sandra ^a   Buchkremer, Gerhard ^a   Köhnke, Michael D ^a,c  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b Wilhelmsheim Hospital   (Germany)

^c Friedrich Petersen Hospital   (Germany)

Author keywords

Alcoholism; Homocysteine; HVA; MTHFR; Neurotoxicity; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOVANILLIC ACID;

ADULT; ALCOHOL ABSTINENCE; ALCOHOLISM; ALLELE; ARTICLE; BLOOD ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; ALCOHOLISM; ALLELES; DOPAMINE; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HOMOCYSTEINE; HOMOVANILLIC ACID; HOMOZYGOTE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 33947145270     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2006.00046.x     Document Type: Article

References (40)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Press.
2. Amin F, Davidson M, Davis KL (1992) Homovanillic acid measurement in clinical research: a review of methodology. Schizophr Bull 18:123-148.
3. Bleich S, Degner D, Bandelow B, von-Ahsen N, Ruther E, Kornhuber J (2000b) Plasma homocysteine is a predictor of alcohol withdrawal seizures. Neuroreport 11:2749-2752.
4. Bleich S, Degner D, Wiltfang J, Maler JM, Niedmann P, Cohrs S, Mangholz A, Porzig J, Sprung R, Ruther E, Kornhuber J (2000a) Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol 35:351-354.
5. Bleich S, Spilker K, Kurth C, Degner D, Quintela-Schneider M, Javaheripour K, Ruther E, Kornhuber J, Wiltfang J (2000c) Oxidative stress and an altered methionine metabolism in alcoholism. Neurosci Lett 293:171-174.
6. Bottiglieri T, Hyland K, Laundy M, Godfrey P, Carney MW, Toone BK, Reynolds EH (1992) Folate deficiency, biopterin and monoamine metabolism in depression. Psychol Med 22:871-876.
7. Bottiglieri T, Laundy M, Crellin R, Toone BK, Carney MWP, Reynolds EH (2000) Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 69:228-232.
8. Chango A, Potier-De-Courcy G, Boisson F, Guilland JC, Barbe F, Perrin MO, Christides JP, Rabhi K, Pfister M, Galan P, Hercberg S, Nicolas JP (2000) 5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) cohort. Br J Nutr 84:891-896.
9. Cravo ML, Camilo ME (2000) Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins B(6) and B(12) status. Nutrition 16:296-302.
10. Cubells JF, Kobayashi K, Nagatsu T, Kidd KK, Kidd JR, Calafell F, Kranzler HR, Ichinose H, Gelernter J (1997) Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). Am J Med Genet 74:374-379.
11. Davidson M, Giordani AB, Mohs RC, Mykytyn VV, Platt S, Aryan ZS, Davis KL (1987) Control of exogenous factors affecting plasma homovanillic acid concentration. Psychiatry Res 20:307-312.
12. Eisenhofer G, Aneman A, Hooper D, Holmes C, Goldstein D-S, Friberg P (1995) Production and metabolism of dopamine and norepinephrine in mesenteric organs and liver of swine. Am J Physiol 268:641-649.
13. Fadda F, Colombo G, Gessa GL (1991) Genetic sensitivity to effects of ethanol on dopaminergic system in alcohol preferring rats. Alcohol Alcohol Suppl 1:439-442.
14. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den-Heijer M, Kluijtmans LA, van-den-Heuvel LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113.
15. Fulton MK, Kramer G, Moeller FG, Chae Y, Isbell PG, Petty F (1995) Low plasma homovanillic acid levels in recently abstinent alcoholic men. Am J Psychiatry 152:1819-1820.
16. Gabel S (1995) Homovanillic acid and dopamine-β-hydroxylase in male youth: relationships with paternal substance abuse and antisocial behavior. Am J Drug Alcohol Abuse 21:363-378.
17. Geracioti TD, West SA, Baker DG, Hill KK, Ekhator NN, Wortman MD, Keck PE, Norman AB (1999) Low CSF concentration of a dopamine metabolite in tobacco smokers. Am J Psychiatry 156:130-132.
18. Goodwin FK (1988) Alcoholism research: delivering on the promise. Public Health Rep 103:569-574.
19. Goyette P, Frosst P, Rosenblatt DS, Rozen R (1995) Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency. Am J Hum Genet 56:1052-1059.
20. Gudnason V, Stansbie D, Scott J, Bowron A, Nicaud V, Humphries S (1998) C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group. Atherosclerosis 136:347-354.
21. Heinz A, Weingartner H, George D, Hommer D, Wolkowitz OM, Linnoila M (1999) Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations. Psychiatry Res 89:97-106.
22. Kiianmaa K, Tuomainen P, Makova N, Seppa T, Mikkola JA, Petteri-Piepponen T, Ahtee L, Hyytia P (2000) The effect of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats. Eur J Pharmacol 407:293-302.
23. Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H, Strain JJ, McPartlin J, Scott JM, Whitehead AS (2003) Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 101:2483-2488.
24. Köhnke MD, Kolb W, Lutz U, Schick S, Wiatr G, Batra A. Allele distribution of a monoamine oxidase A gene promoter polymorphism in German alcoholics and in subgroups with severe forms of alcohol withdrawal and its influence on plasma homovanillic acid. Psychiatr Genet, in press.
25. Köhnke MD, Wiatr G, Kolb W, Köhnke AM, Schick S, Lutz U, Vonthein R, Gaertner I (2003) Plasma homovanillic acid: a significant association with alcoholism is independent of a functional polymorphism of the human catechol-O-methyltransferase gene. Neuropsychopharmacology 28:1004-1010.
26. Lee ES, Chen H, Soliman KF, Charlton CG (2005) Effects of homocysteine on the dopaminergic system and behavior in rodents. Neurotoxicology 26:361-371.
27. McBride WJ, Bodart B, Lumeng L, Li TK (1995) Association between low contents of dopamine and serotonin in the nucleus accumbens and high alcohol preference. Alcohol Clin Exp Res 19:1420-1422.
28. Mares P, Folbergrova J, Langmeier M, Haugvicova R, Kubova H (1997) Convulsant action of D,1-homocysteic acid and its stereoisomers in immature rats. Epilepsia 38:767-776.
29. Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
30. Petrakis IL, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal JH (1999) CSF monoamine metabolite and beta endorphin levels in recently detoxified alcoholics and healthy controls: prediction of alcohol cue-induced craving? Alcohol Clin Exp Res 23:1336-1341.
31. Pietila K, Laakso I, Ahtee L (1995) Chronic oral nicotine administration affects the circadian rhythm of dopamine and 5-hydroxytryptamine metabolism in the striata of mice. Naunyn Schmiedebergs Arch Pharmacol 353:110-115.
32. Russo GT, Friso S, Jacques PF, Rogers G, Cucinotta D, Wilson PW, Ordovas JM, Rosenberg IH, Selhub J (2003) Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort. J Nutr 133:3416-3421.
33. Salminen O, Ahtee L (2000) The effects of acute nicotine on the body temperature and striatal dopamine metabolism of mice during chronic nicotine infusion. Neurosci Lett 284:37-40.
34. Stickel F, Choi SW, Kim YI, Bagley PJ, Seitz HK, Russell RM, Selhub J, Mason JB (2000) Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res 24:259-264.
35. de-la-Vega MJ, Santolaria F, Gonzalez-Reimers E, Aleman MR, Milena A, Martinez-Riera A, Gonzalez-Garcia C (2001) High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR). Alcohol 25:59-67.
36. Wittchen HU, Zaudig M, Fydrich T (1997) SKID. Strukturiertes Klinisches Interview fuer DSM-IV (Users Guide for the Structured Clinical Interview for DSM-IV, modified version), (Original: First MB, Gibbon M, Spitzer RL, Williams JBW (1996). SCID-I; SCID-II); Testzentrale, Robert-Bosch-Breite 25, 37079 Goettingen, Germany.
37. Wood PL, Altar CA (1988) Dopamine release in vivo from nigrostriatal, mesolimbic and mesocortical neurons: utility of 3-methoxytyramine measurements. Pharmacol Rev 40:163-187.
38. Yasui K, Kowa H, Nakaso K, Takeshima T, Nakashima K (2000) Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 55:437-440.
39. Zalsman G, Huang YY, Harkavy-Friedmann JM, Oqundo MA, Ellis SP, Mann JJ (2005) Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of Caucasians: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 132:100-103.
40. Zhao WQ, Williams Z, Shepherd KR, Reuben JS, Lee ES, Darling-Reed S, Lamango N, Soliman KF, Charlton CG (2002) Sadenosyl-methionine-induced apoptosis in PC12 cells. J Neurosci Res 69:519-529.