Transgenic Animals in Experimental Xenotransplantation Models: Orthotopic Heart Transplantation in the Pig-to-Baboon Model

Transplantation Proceedings

Volumn 39, Issue 2, 2007, Pages 577-578

  Brandl, U ^a   Michel, S ^a   Erhardt, M ^a   Brenner, P ^a   Burdorf, L ^a   Jockle H ^a   Bittmann, I ^a   Rossle M ^a   Mordstein, V ^a   Baschnegger, H ^a   Bauer, A ^a   Hammer, C ^a   Reichart, B ^a   Schmoeckel, M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSIDASE; CYCLOPHOSPHAMIDE; GAS 914; HLA ANTIBODY; METHYLPREDNISOLONE; RAPAMYCIN; RITUXIMAB; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; BABOON; BLOOD CELL COUNT; COMPLEMENT DEPOSITION; CONTROLLED STUDY; DRUG MONITORING; GRAFT FAILURE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOLOGY; IMMUNOGLOBULIN DEPOSITION; MALE; MORTALITY; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; SWINE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD55; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 33947118793     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.12.021     Document Type: Article

References (10)

1. Galili U. The α-Gal epitope (Galα1-3Gal1-4GlcNAc-R) in xenotransplantation. Biochimie 83 (2001) 557
2. Teranishi K., Alwayn I.P.J., Bühler L., et al. Depletion of anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model. Transplant Proc 34 (2002) 2757
3. Cozzi E., and White D.J.G. Characterization of pigs transgenic for human decay accelerating factor. Transplantation 64 (1997) 1383
4. Diamond L.E., Quinn C.M., and Martin M.J. A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 71 (2001) 132
5. Niemann H., Verhoeyen E., Wonigeit K., et al. Cytomegalovirus early promotor induced expression of hCD59 in porcine organs provides protection against hyperacute rejection. Transplantation 72 (2001) 1898
6. Brandl U., Michel S., Erhardt M., et al. Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation model. Xenotransplantation 12 (2005) 134
7. Goddard M.J., Dunning J., Horsley J., et al. Histopathology of cardiac xenograft rejection in the pig-to-baboon model. J Heart Lung Transplant 23 (2004) 505
8. Schmoeckel M., Bhatti F., Zaidi A., et al. Orthotopic heart transplantation in a transgenic pig-to-primate model. Transplantation 65 (1998) 1570
9. Hering B.J., Wijkstrom M., Graham M.L., et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 12 (2006) 301
10. Cardona K., Korbutt G.S., Milas Z., et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting co-stimulation pathways. Nat Med 12 (2006) 304