Thromboembolism in childhood nephrotic syndrome: A rare but serious complication

Hematology

Volumn 12, Issue 1, 2007, Pages 69-73

  Zaffanello, Marco ^a   Franchini, Massimo ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b Verona Hospital   (Italy)

Author keywords

Children; Nephrotic syndrome; Thrombophilia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACETYLSALICYLIC ACID; ALTEPLASE; ANTICOAGULANT AGENT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; FIBRINOGEN; FIBRINOLYTIC AGENT; HEPARIN; HUMAN ALBUMIN; LIPID; LOW MOLECULAR WEIGHT HEPARIN; PROTEIN; PROTEIN C; PROTEIN S; PROTHROMBIN; STEROID; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; WARFARIN;

ANTICOAGULANT THERAPY; ARTERY THROMBOSIS; BUDD CHIARI SYNDROME; CEREBRAL SINUS THROMBOSIS; CHILDHOOD DISEASE; CLINICAL FEATURE; CLINICAL TRIAL; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTINUOUS INFUSION; DEEP VEIN THROMBOSIS; DISEASE EXACERBATION; EDEMA; FAMILY HISTORY; HEPARINIZATION; HUMAN; HYPERCOAGULABILITY; HYPERLIPIDEMIA; HYPOALBUMINEMIA; LEG THROMBOSIS; LOW DRUG DOSE; LUNG ANGIOGRAPHY; LUNG EMBOLISM; NEPHROTIC SYNDROME; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; PATHOGENESIS; PHLEBOGRAPHY; PLASMA TRANSFUSION; PRIORITY JOURNAL; PROTEIN S DEFICIENCY; PROTEINURIA; REVIEW; RISK FACTOR; THROMBOEMBOLISM; THROMBOPHILIA; VEIN THROMBOSIS;

ANTICOAGULANTS; ANTIFIBRINOLYTIC AGENTS; BLOOD COAGULATION DISORDERS, INHERITED; BLOOD COAGULATION FACTORS; CHILD; HUMANS; HYPOALBUMINEMIA; INCIDENCE; NEPHROTIC SYNDROME; PROTEINURIA; THROMBOEMBOLISM; THROMBOPHILIA;

EID: 33947116336     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1080/10245330600940048     Document Type: Review

References (54)

1. Richardson, MW, Allen, GA and Monahan, PE (2002) Thrombosis in children: Current perspective and distinct challenges. Thromb Haemost, 88, pp. 900-911.
2. Revel-Vilk, S. and Massicotte, P. (2003) Thromboembolic diseases of childhood. Blood Rev, 17, pp. 1-6.
3. Coccheri, S. and Palareti, G. (1994) Pro-thrombotic states and their diagnosis. Ann Ital Med Int, 9, pp. 16-21.
4. Cameron, JS (1984) Coagulation and thromboembolic complications in the nephrotic syndrome. Adv Nephrol, 13, pp. 75-114.
5. Citak, A., Emre, S., Sairin, A., Bilge, I. and Nayir, A. (2000) Hemostatic problems and thromboembolic complications in nephrotic children. Pediatr Nephrol, 14, pp. 138-142.
6. Abella, EM (1994) Hemostatic problems associated with renal disease. Int J Pediatr Hematol Oncol, 1, pp. 43-51.
7. Tinaztepe, K., Buyan, N., Tinaztepe, B. and Akkok, N. (1989) The association of nephrotic syndrome and renal vein thrombosis: A clinicopathological analysis of eight pediatric patients. Turk J Pediatr, 31, pp. 1-18.
8. Hoyer, PF, Gonda, S., Barthels, M., Krohn, HP and Brodehl, J. (1986) Thromboembolic complications in children with nephrotic syndrome. Risk and incidence. Acta Paediatr Scand, 75, pp. 804-810.
9. Orth, SR and Ritz, E. (1998) The nephrotic syndrome. N Engl J Med, 338, pp. 1202-1211.
10. Ozkayin, N., Mir, S. and Kavakli, K. (2004) Hypercoagulability risk factors in children with minimal change disease and the protective role of protein-C activity. Int Urol Nephrol, 36, pp. 599-603.
11. Crew, RJ, Radhakrishnan, J. and Appel, G. (2004) Complications of the nephrotic syndrome and their treatment. Clin Nephrol, 62, pp. 245-259.
12. Lau, SO, Tkachuck, JY, Hasegawa, DK and Edson, JR (1980) Plasminogen and antithrombin III deficiencies in the childhood nephrotic syndrome associated with plasminogenuria and antithrombinuria. J Pediatr, 96, pp. 390-392.
13. Hanevold, CD, Lazarchick, J., Constantin, MA, Hiott, KL and Orak, JK (1996) Acquired free protein S deficiency in children with steroid resistant nephrosis. Ann Clin Lab Sci, 26, pp. 279-282.
14. Kemkes-Matthes, B. (1992) Acquired protein S deficiency. Clin Invest, 70, pp. 529-534.
15. Harris, RC and Ismail, N. (1994) Extrarenal complications of the nephrotic syndrome. Am J Kidney Dis, 23, pp. 477-497.
16. Colle, JP, Mishal, Z. and Lesty, C. (1999) Abnormal fibrin clot architecture in nephrotic patients is related to hypofibrinolysis: Influence of plasma biochemical modifications: A possible mechanism for the high thrombotic tendency?. Thromb Haemost, 82, pp. 1482-1489.
17. Yoshida, N. and Aoki, N. (1978) Release of arachidonic acid from human platelets. A key role for the potentiation of platelet aggregability in normal subjects as well as in those with nephrotic syndrome. Blood, 52, pp. 969-977.
18. Machleidt, C., Mettang, T., Starz, E., Weber, J., Risler, T. and Kuhlmann, U. (1989) Multifactorial genesis of enhanced platelet aggregability in patients with nephrotic syndrome. Kidney Int, 36, pp. 1119-1124.
19. Llach, F. (1985) Hypercoagulability, renal vein thrombosis, and other thrombotic complications of nephrotic syndrome. Kidney Int, 28, pp. 429-439.
20. Andrew, M. and Brooker, LA (1996) Hemostatic complications in renal disorders of the young. Pediatr Nephrol, 10, pp. 88-99.
21. Lilova, MI, Velkovski, IG and Topalov, IB (2000) Thromboembolic complications in children with nephrotic syndrome in Bulgaria (1974-1996). Pediatr Nephrol, 15, pp. 74-78.
22. Nowak-Gottl, U., Kosch, A. and Schlegel, N. (2003) Neonatal thromboembolism. Semin Thromb Hemost, 29, pp. 227-234.
23. Fabri, D., Belangero, VM, Annichino-Bizzacchi, JM and Arruda, VR (1998) Inherited risk factors for thrombophilia in children with nephrotic syndrome. Eur J Pediatr, 157, pp. 939-942.
24. Ulinski, T., Guigonis, V., Baudet-Bonneville, V., Auber, F., Garcette, K. and Bensman, A. (2003) Mesenteric thrombosis causing short bowel syndrome in nephrotic syndrome. Pediatr Nephrol, 18, pp. 1295-1297.
25. Campisi, S. and Cavatorta, F. (1998) A case of deep vein thrombosis in idiopathic nephrotic syndrome with resistance to activated protein C. J Nephrol, 11, pp. 76-77.
26. Ara, J Martinez, Rioja, R Gomez, Rinon, C., Munoz, Garcia MS, Caravaca, ML Ruiz and Miguel, JL (2000) Prevalence of genetic prothrombotic factors (factor V Leiden and II20210 prothrombin mutation) in glomerular nephropathies with or without thrombosis. Nefrologia, 20, pp. 139-144.
27. Kanfer, A. (1990) Coagulation factors in nephrotic syndrome. Am J Nephrol, 10, pp. 63-68.
28. Mehls, O., Andrassy, K., Koderisch, J., Herzog, U. and Ritz, E. (1987) Hemostasis and thromboembolism in children with nephrotic syndrome: Differences from adults. J Pediatr, 110, pp. 862-867.
29. Louis, CU, Morgenstern, BZ and Butani, L. (2003) Thrombotic complications in childhood-onset idiopathic membranous nephropathy. Pediatr Nephrol, 18, pp. 1298-1300.
30. Garbrecht, F., Gardner, S., Johnson, V. and Grabowski, E. (1991) Deep venous thrombosis in a child with nephrotic syndrome associated with a circulating anticoagulant and acquired protein S deficiency. Am J Pediatr Hematol Oncol, 13, pp. 330-333.
31. van Ommen, CH, Heyboer, H., Groothoff, JW, Teeuw, R., Aronson, DC and Peters, M. (1998) Persistent tachypnea in children: Keep pulmonary embolism in mind. J Pediatr Hematol Oncol, 20, pp. 570-573.
32. Deshpande, PV and Griffiths, M. (2005) Pulmonary thrombosis in steroid-sensitive nephrotic syndrome. Pediatr Nephrol, 20, pp. 665-669.
33. Cherng, SC, Huang, WS, Wang, YF, Yang, SP and Lin, YF (2000) The role of lung scintigraphy in the diagnosis of nephrotic syndrome with pulmonary embolism. Clin Nucl Med, 25, pp. 167-172.
34. Appenzeller, S., Zeller, CB and Annichino-Bizzachi, JM (2005) Cerebral venous thrombosis: Influence of risk factors and imaging findings on prognosis. Clin Neurol Neurosurg, 107, pp. 371-378.
35. Palcoux, JB, Gaspard, F. and Campagne, D. (2003) Cerebral sinus thrombosis in a child with steroid-resistant nephrotic syndrome. Pediatr Nephrol, 18, pp. 610-611.
36. Gangakhedkar, A., Wong, W. and Pitcher, LA (2005) Cerebral thrombosis in childhood nephrosis. J Paediatr Child Health, 41, pp. 221-224.
37. Lin, CC, Lui, CC and Tain, YL (2002) Thalamic stroke secondary to straight sinus thrombosis in a nephrotic child. Pediatr Nephrol, 17, pp. 184-186.
38. Witz, M., Lehman, J., Shnaker, A. and Korzets, Z. (2004) Acute subclavian and brachial artery thrombosis as a complication of the nephrotic syndrome. Isr Med Assoc J, 6, pp. 441-442.
39. Siddiqi, FA, Tepler, J. and Fantini, GA (1997) Acquired protein S and antithrombin III deficiency caused by nephrotic syndrome: An unusual cause of graft thrombosis. J Vasc Surg, 25, pp. 576-580.
40. Weisz, W., Kemper, MJ, Weil, J. and Muller-Wiefel, DE (2002) Asymptomatic intracardiac thrombus in steroid-sensitive nephrotic syndrome. Pediatr Nephrol, 17, pp. 287-289.
41. Passos, EM, Legallicier, B. and Godin, M. (2003) Embranous nephropathy. Rev Prat, 53, pp. 2033-2038.
42. Osula, S., Bell, GM and Hornung, RS (2002) Acute myocardial infarction in young adults: Causes and management. Postgrad Med J, 78, pp. 27-30.
43. Segel, GB and Francis, CA (2000) Anticoagulant proteins in childhood venous and arterial thrombosis: A review. Blood Cells Mol Dis, 26, pp. 540-560.
44. Hoppe, C. and Matsunaga, A. (2002) Pediatric thrombosis. Pediatr Clin North Am, 49, pp. 1257-1283.
45. Lilova, MI, Velkovski, IG and Velichkov, NI (2000) Budd-Chiari syndrome and inferior vena cava thrombosis in a nephrotic child. Pediatr Nephrol, 14, pp. 412-415.
46. Ruud, E., Holmstrom, H. and Aagenaes, I. (2003) Successful thrombolysis by prolonged low-dose alteplase in catheter-directedinfusion. Acta Paediatr, 92, pp. 973-976.
47. Crabbe, SJ and Cloninger, CC (1987) Tissue plasminogen activator: A new thrombolytic agent. Clin Pharm, 6, pp. 373-386.
48. Kandler, C., Ries, M., Rupprecht, T., Ruder, H. and Harms, D. (1997) Successful systemic low-dose lysis of a caval thrombus by rt-PA in a neonate with congenital nephrotic syndrome. J Pediatr Hematol Oncol, 19, pp. 348-350.
49. Kennedy, LA, Drummond, WH, Knight, ME, Millsaps, MM and Williams, JL (1990) Successful treatment of neonatal aortic thrombosis with tissue plasminogen activator. J Pediatr, 116, pp. 798-801.
50. Manco-Johnson, MJ, Grabowski, EF and Hellgreen, M. (2002) Recommendations for tPA thrombolysis in children. Thromb Haemost, 88, pp. 157-158.
51. Parasuraman, S. and Goldhaber, SZ (2006) Venous thromboembolism in children. Circulation, 113, pp. e12-e16.
52. Mittal, B Rai, Singh, S., Bhattacharya, A., Prasad, V. and Singh, B. (2005) Lung scintigraphy in the diagnosis and follow-up of pulmonary thromboembolism in children with nephrotic syndrome. Clin Imaging, 29, pp. 313-316.
53. Tullu, MS, Deshmukh, CT, Save, SU, Bhoite, BK and Bharucha, BA (1999) Superior sagittal sinus thrombosis: A rare complication of nephrotic syndrome. J Postgrad Med, 45, pp. 120-122.
54. Papachristou, FT, Petridou, SH, Printza, NG, Zafeiriou, DI and Gompakis, NP (2005) Superior sagittal sinus thrombosis in steroid-resistant nephrotic syndrome. Pediatr Neurol, 32, pp. 282-284.