Neonatal thromboembolism

Seminars in Thrombosis and Hemostasis

Volumn 29, Issue 2, 2003, Pages 227-233

  Nowak Göttl, Ulrike ^a   Kosch, Andrea ^a   Schlegel, Nicole ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Anticoagulation; Infants; Neonates; Thrombophilia; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; D DIMER; FRESH FROZEN PLASMA; HEPARIN; LIPOPROTEIN A; LOW MOLECULAR WEIGHT HEPARIN; PROTEIN C; PROTEIN S; PROTHROMBIN; STREPTOKINASE; UROKINASE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANTICOAGULANT THERAPY; ANTITHROMBIN DEFICIENCY; BLOOD CLOTTING FACTOR 5 DEFICIENCY; CENTRAL VENOUS CATHETER; CONGENITAL NEPHROTIC SYNDROME; DEHYDRATION; DIAGNOSTIC IMAGING; EXTRACORPOREAL CIRCULATION; FULMINATING PURPURA; HEART DISEASE; HEMOLYTIC UREMIC SYNDROME; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; KIDNEY DISEASE; LABORATORY DIAGNOSIS; NECROTIZING ENTEROCOLITIS; NEONATAL THROMBOEMBOLISM; NEWBORN; OUTCOMES RESEARCH; PARTIAL THROMBOPLASTIN TIME; PATHOPHYSIOLOGY; PERINATAL ASPHYXIA; POLYCYTHEMIA; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; PROTHROMBIN DEFICIENCY; PROTHROMBIN TIME; REFERENCE VALUE; RESPIRATORY DISTRESS SYNDROME; REVIEW; SEPTICEMIA; THROMBOCYTOPENIA; THROMBOEMBOLISM; THROMBOGENESIS; THROMBOPHILIA; THROMBUS;

BLOOD PROTEINS; HEMOSTASIS; HUMANS; INFANT; INFANT, NEWBORN; RISK FACTORS; THROMBOEMBOLISM; TREATMENT OUTCOME;

EID: 17044449454     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-38839     Document Type: Review

References (67)

1. Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 1995;95:936-943
2. Nowak-Göttl U, von Kries R, Göbel U. Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child 1997;76:F163-F167
3. Nowak-Göttl U, Dübbers A, Kececioglu D, et al. Factor V Leiden, protein C and lipoprotein (a) in catheter related thrombosis in childhood - a prospective study. J Pediatr 1997;131:608-612
4. Vitiello R, McCrindle BW, Nykanen D, et al. Complications associated with pediatric cardiac catheterization. J Am Col Cardiol 1998;32:1433-140
5. Salonvaara M, Riikonen P, Kekomaki R, et al. Clinical symptomatic central venous catheter-related deep venous thrombosis in newborns. Acta Paediatr 1999;88:642-646
6. Boo NY, Wong NC, Zulkifli SS, et al. Risk factors associated with umbilical vascular catheter-associated thrombosis in newborn infants. J Pediatr Child Health 1999;35:460-465
7. Schwartz DS, Gettner PA, Konstantino MM, et al. Umbilical venous catheterization and the risk of portal vein thrombosis. J Pediatr 1997;131:760-762
8. Sträter R, Vielhaber H, Kassenböhmer R, et al. Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey. Eur J Pediatr 1999;158:S122-S125
9. Schlegel N. Thromboembolic risks and complications in nephrotic children. Semin Thromb Hemost 1997;23:271-280
10. Hagstrom JN, Walter J, Bluebond-Langner R, et al. Prevalence of the factor V Leiden mutation in children and neonates with thromboembolic disease. J Pediatr 1998;133:777-781
11. Heller C, Schobess R, Kurnik K, et al. Abdominal venous thrombosis in neonates and infants: Role of prothrombotic risk factors - a multicentre case-control study. Br J Haematol 2000;111:534-539
12. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 1. Thromb Haemost 1996;76:651-662
13. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993;90:1004-1008
14. Bertina RM, Koeleman BPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67
15. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-3703
16. Mudd SH, Skovby F, Levy HL, et al. The natural history of homocystinuria due to cystathionine-beta-synthase deficiency. Am J Hum Genet 1985;37:1-31
17. Nowak-Göttl U, Junker R, Hartmeier M, et al. Increased lipoprotein (a) is an important risk factor for venous thrombosis in childhood. Circulation 1999;100:743-748
18. Nowak-Göttl U, Sträter R, Heinecke A, et al. Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin and methylenetetrahydrofolate reductase are risk factors of ischaemic stroke in childhood. Blood 1999;94:3678-3682
19. Ehrenforth S, Junker R, Koch HG, et al. Multicentre evaluation of combined prothrombotic defects with thrombophilia in childhood. Eur J Pediatr 1999;158:S97-S104
20. Junker R, Koch HG, Auberger K, et al. Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia. Arterioscler Thromb Vasc Biol 1999;19:2568-2572
21. Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost 1995;74:415-425
22. Ries M, Klinge J, Rauch R. Age-related reference values for activation markers of the coagulation and fibrinolytic systems in children. Thromb Res 1997;85:341-344
23. Schwarz HP, Muntean W, Watzke H, et al. Low total protein S antigen but higher protein S activity due to decreased C4b-binding protein in neonates. Blood 1988;71:562-565
24. Cvirn G, Gallistl S, Muntean W. Effects of antithrombin and protein C on thrombin generation in newborn and adult plasma. Thromb Res 1999;93:183-190
25. Andrew M, Schmidt B, Mitchell L, et al. Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb Haemost 1990;63:27-30
26. Ries M, Klinge J, Rauch R, et al. In vitro fibrinolysis after adding low doses of plasminogen activators and plasmin generation with and without oxidative inactivation of plasmin inhibitors in newborns and adults. J Ped Hematol Oncol 1996;18:346-351
27. Salafia CM, Vintzileos AM, Silberman L, et al. Placental pathology of idiopathic intrauterine growth retardation at term. Am J Perinatol 1992;9:179-184
28. Brenner B, Sarig G, Weiner Z, et al. Thrombophilic polymorphisms are common in women with foetal loss without apparent cause. Thromb Haemost 1999;82:6-9
29. Dizon-Townson DS, Meline L, Nelson LM, et al. Foetal carriers of the factor V Leiden are prone to miscarriage and placental infarction. Am J Obstet Gynecol 1997;177:402-405
30. Berg K, Roland B, Sande H. High Lp(a) lipoprotein level in maternal serum may interfere with placental circulation and cause foetal growth retardation. Clin Genet 1994;46:52-56
31. Pabinger I, Grafenhofer H, Kaider A, et al. Preeclampsia and fetal loss in women with a history of venous thromboembolism. Arterioscler Thromb Vasc Biol 2001;21:874-879
32. Göpel W, Kim D, Gortner L. Prothrombotic mutations as a risk factor for preterm birth. Lancet 1999;353:1411-1412
33. Verspyck E, Le Camp-Duchez V, Gravier A, et al. Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A). Eur J Obstet Gynecol Reprod Biol 1999;83:143-144
34. von Kries R, Junker R, Oberle D, Kosch A, Nowak-Göttl U. Foetal growth restriction in children with prothrombotic risk factors. Thromb Haemost 2001;86:1012-1016
35. Vries de LS, Eken P, Groenendaal F, et al. Antenatal onset of haemorrhagic and/or ischaemic lesions in preterm infants: prevalence and associated obstetric variables. Arch Dis Child 1998;78:F51-F56
36. Kraus FT, Acheen VI. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol 1999;30:759-769
37. Debus O, Koch HG, Kurlemann G, et al. Factor V Leiden and genetic defects of thrombophilia in childhood porencephaly. Arch Dis Child 1998;78:F121-F124
38. Govaets P, Matthys E, Zecic A, et al. Perinatal cortical infarction within middle cerebral artery trunks. Arch Dis Child 2000;82:F59-F63
39. Vielhaber H, Ehrenforth S, Koch HG, et al. Cerebral venous thrombosis in infancy and childhood: role of genetic and acquired risk factors of thrombophilia. Eur J Pediatr 1998;157:555-560
40. Mocan H, Beattie TJ, Murphy AV. Renal venous thrombosis in infancy: long-term follow-up. Pediatr Nephrol 1991;5:45-49
41. Bökenkamp A, von Kries R, Nowak-Göttl U, et al. Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome. Eur J Pediatr 2000;159:44-48
42. Riikonen RS, Vahtera EM, Kekomäki RM. Physiological anticoagulants and activated protein C resistance in childhood stroke. Acta Paediatr 1996;85:242-244
43. Zenz W, Bodo Z, Plotho J, et al. Factor V Leiden and prothrombin gene G20210A variant in children with stroke. Thromb Haemost 1998;80:763-766
44. Van Beynum IM, Smeitink JA, den Heijer M, et al. Hyperhomocysteinemia: a risk for ischaemic stroke in children. Circulation 1999;99:2070-2072
45. Kenet G, Sadetzki S, Murad H, et al. Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischaemic stroke in children. Stroke 2000;31:1283-1288
46. Günther G, Junker R, Sträter R, et al. Symptomatic ischaemic stroke in full-term neonates: role of acquired and genetic prothrombotic risk factors. Stroke 2000;31:246-251
47. Laeson SE, Butler D, Enayat MS, Williams MD. Congenital thrombophilia and thrombosis: a study in a single centre. Arch Dis Child 1999;81:176-178
48. Bonduel M, Hepner M, Sciuccati G, et al. Prothrombotic abnormalities in children with venous thromboembolism. J Pediatr Hematol Oncol 2000;22:66-72
49. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 2. Thromb Haemost 1996;76:824-834
50. Manco-Johnson M, Abshire T, Jacobson L, Marlar R. Severe neonatal protein C deficiency: prevalence and thrombotic risk. J Pediatr 1991;119:793-798
51. Manco-Johnson MJ, Nuss R, Key N, et al. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. J Pediatr 1996;128:319-323
52. Andrew M, Paes B, Johnston M. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 1990;12:95-104
53. Häuseler M, Duyue D, Merz U, et al. The clinical outcome after inferior vena cava thrombosis in early infancy. Eur J Pediatr 1999;158:416-420
54. Andrew M, Michelson AD, Bovill E, et al. Guidelines for antithrombotic therapy in pediatric patients. J Pediatr 1998;132:575-588
55. Massicotte P, Adams M, Marzinotto V, et al. Low molecular weight heparin in pediatric patients with thrombotic disease: a dose finding study. J Pediatr 1996;128:313-318
56. Dix D, Andrew M, Marzinotto V, et al. The use of low molecular weight heparin in pediatric patients: a prospective cohort study. J Pediatr 2000;136:439-445
57. Kirk CR, Qureshi SA. Streptokinase in the management of arterial thrombosis in infancy. Int J Cardiol 1989;25:15-20
58. Nowak-Göttl U, Schwabe D, Schneider W, et al. Thrombolysis with recombinant tissue-type plasminogen activator in renal venous thrombosis in infancy. Lancet 1992;340:1005
59. Wever ML, Liem KD, Geven WB, Tanke RB. Urokinase therapy in neonates with catheter related central venous thrombosis. Thromb Haemost 1995;73:180-185
60. Farnoux C, Camard O, Pinquier D, et al. Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates. J Pediatr 1998;133:137-140
61. Weiner GM, Castle VP, DiPietro MA, Faix RG. Successful treatment of neonatal arterial thrombosis with recombinant tissue plasminogen activator. J Pediatr 1998;133:133-136
62. Nowak-Göttl U, Auberger K, Halimeh S, et al. Thrombolysis in newborns and infants. Thromb Haemost 1999;82:S112-S116
63. Manco-Johnson MJ, Nuss R, Krupski W, et al. Combined thrombolytic and anticoagulant therapy for venous thrombosis in children. J Pediatr 2000;136:446-453
64. Marlar RA, Montgomery R, Broeckmans AW. Diagnosis and treatment of homozygous protein C deficiency. J Pediatr 1989;114:528-534
65. Dreyfus M, Magny JF, Bridey F, et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with purified protein C concentrate. N Engl J Med 1991;325:1565-1568
66. Monagle P, Adams M, Mahoney M, et al. Outcome of pediatric thromboembolic disease: a report from the Canadian childhood thrombophilia registry. Ped Res 2000;47:763-766
67. Nowak-Göttl U, Junker R, Kreuz W, et al. Risk of recurrent thrombosis in children with combined prothrombotic risk factors. Blood 2001;97:858-862