Hemostatic complications in renal disorders of the young

Pediatric Nephrology

Volumn 10, Issue 1, 1996, Pages 88-99

  Andrew, Maureen ^a   Brooker, Lu Ann ^a  

^a HAMILTON HEALTH SCIENCES   (Canada)

Author keywords

Hemostasis; Renal disorders; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; COUMARIN ANTICOAGULANT; HEPARIN; WARFARIN;

FIBRINOLYTIC THERAPY; GLOMERULONEPHRITIS; HEMOLYTIC UREMIC SYNDROME; HEMOSTASIS; HUMAN; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY HEMORRHAGE; KIDNEY TRANSPLANTATION; KIDNEY VEIN THROMBOSIS; NEPHROTIC SYNDROME; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; THROMBOEMBOLISM;

EID: 0030025762     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00863459     Document Type: Review

References (135)

1. Schmidt B, Andrew M (1995) Neonatal thrombosis: report of a prospective Canadian and International registry. Pediatrics (in press)
2. Harris JD, Ehrenfeld WK, Lee JC, Wylie EJ (1968) Experimental renal vein occlusion. Surg Gynecol Obstetr 126: 555
3. Crummy AB, Hipona FA (1965) The roentgen diagnosis of renal vein thrombosis; experimental aspects. Am J Roentgen 93: 898
4. Koehler PR, Bowles WT, McAlister WH (1966) Renal arteriography in experimental renal vein occlusion. Radiology 86: 851
5. Osborne ED, Sutherland CG, Scholl AG, Rowntree LG. Landmark article Feb 10, 1923: Roentgenography of urinary tract during excretion of Sodium iodide. Jama 250 (20): 2818-2853, 1983
6. Rogers P, Silva M, Carter J, Wadsworth L (1989) Renal vein thrombosis and response to therapy in a newborn due to protein C deficiency. Eur J Pediatr 149: 124-125
7. Kaplan BS, Cleary TG, Obrig TG (1990) Recent advances in understanding the pathogenesis of the hemolytic uremic syndromes. Pediatr Nephrol 4: 276-283
8. Loirat C, Sonsino E, Hinglais N, Jais J, Landais P, Fermanian J (1988) Treatment of the childhood haemolytic uraemic syndrome with plasma. Pediatr Nephrol 2: 279-285
9. Rizzoni G, Claris-Appiani A, Edefonti A, Facchin P, Franchini F, Gusmano R, Imbasciati E, Pavanello L, Perfumo F, Remuzzi G (1988) Plasma infusion for hemolytic-uremic syndrome in children: results of a multi-center controlled trial. J Pediatr 112: 284-290
10. Vitacco M, Avalos J, Gianantonio C (1973) Heparin therapy in the hemolytic-uremic sydrome. J Pediatr 83: 271-275
11. Robson W, Leung AKC, Kaplan BS (1993) Hemolytic-uremic syndrome. Curr Opin Pediatr 23 (1): 16-33
12. Kar NCAJ van der, Hmsbergh VWM van, Brommer EJP, Monnens LAH (1994) The fibrinolytic system in the hemolytic uremic syndrome: in vivo and in vitro studies. Pediatr Res 36: 257-264
13. Monteagudo J, Pereira A, Reverter JC, Pijoan J, Tusell J, Ordinas A, Castille R (1991) Thrombin generation and fibrinolysis in the thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. Thromb Haemost 55: 515-519
14. Suffredini AF, Harpel PC, Parillo JE (1989) Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects N Engl J Med 320: 1165-1172
15. Hinsbergh VWM van, Bauer KA, Kooistra T, Kluft C, Dooijewaard G, Sherman ML, Nieuwenhuizen W (1990) Progress of fibrinolysis during tumor necrosis factor infusions in humans. Concomitant increase in tissue-type plasminogen activator, plasminogen activator inhibitor type-1, and fibrin(ogen) degradation products. Blood 76: 2284-2289
16. Boyd B, Lingwood C (1989) Verocytotoxin receptor glycolipid in human renal tissue. Nephron 51: 207-210
17. Ogborn MR, Crocker JFS, Barnard DR (1990) Plasma therapy for severe hemolytic-uremic syndrome in children in Altantic Canada. Can Med Assoc J 143: 1323-1326
18. Hoyer PF, Gonda S, Barthels M, Krohn HP, Brodehl J (1986) Thromboembolic complications in children with nephrotic syndrome. Acta Paediatr Scand 75: 804-810
19. Huttunen NP (1976) Congenital nephrotic syndrome of Finnish type. Arch Dis Child 51: 344-348
20. Mahan JD, Mauer SM, Sibley RK, Vernier RL (1984) Congenital nephrotic syndrome: evolution of medical management and results of renal transplantation. J Pediatr 105: 549-557
21. Mehls O, Andrassy K, Koderisch J, Herzog U, Ritz E (1987) Hemostasis and thromboembolism in children with nephrotic syndrome: differences from adults. J Pediatr 110: 862-867
22. Andrassy K, Ritz E, Bommer J (1980) Hypercoagulability in the nephrotic syndrome. Klin Wochenschr 58: 1029-1036
23. Kanfer A, Kleinknecht D, Broyer M, Josso F (1970) Coagulation studies in 45 cases of nephrotic syndrome without uremia. Thromb Diath Haemorrh 24: 562-571
24. Kauffman RH, Keltkamp JJ, Tilburg NH van, Es LA van (1978) Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome. Am J Med 65: 607-613
25. Kuhlmann U, Blattler W, Pouliadis G, Siegenthaler W (1979) Komplikationen des nephrotischen Syndroms unter besonderer Berücksichtigung thrombotischer Zwischenfälle. Schweiz Med Wochenschr 109: 200-209
26. Schrader J, Kostering H, Zuchner C, Kaiser H, Kramer P, Scheler F (1981) Antithrombin III-Bestimmung im Schnelltest: Ein Vergleich mit Partigen-Platten und einem chromogenen Substrat. Lab Med 5: 211-218
27. Thaler E, Baler E, Kopsa H, Pinggera WF (1978) Acquired antithrombin III deficiency in patients with glomerular proteinuria. Haemostasis 7: 257-272
28. Cameron JS (1991) Coagulation and thromboembolic complications in the nephrotic syndrome (Review). Adv Nephrol Advances in Nephrology from the Necker Hospital 13: 75-114, 1984
29. Chugh K, Malik N, Uberoi H, Gupta V, Aggarwal M, Singhal P, Suri S, Jain S (1981) Renal vein thrombosis in nephrotic syndrome - a prospective study and review. Postgrad Med J 57: 566-570
30. Wei LQ, Rong ZK, Gui L, Shan RD (1991) CT diagnosis of renal vein thrombosis in nephrotic syndrome. J Comput Assist Tomogr 15: 454-457
31. Menzel D, Levi M, Dooijewaard G, Peters M, Cate J ten (1994) Impaired fibrinolysis in the hemolytic-uremic syndrome of childhood. Ann Hematol 68: 43-48
32. Schieppati A, Dodesini P, Benigni A (1984) The metabolism of arachidonic acid by platelets in nephrotic syndrome. Kidney Int 25: 671-676
33. Stuart MJ, Spitzer R, Nelson DA, Sills RH (1980) Nephrotic syndrome: increased platelet prostaglandin endoperoxide formation, hyperaggregability, and reduced platelet life span. Reversal following remission. Pediatr Res 14: 1078-1081
34. Cameron J, Gill D, Turner D, Chantler C, Ogg C, Vosnides G, Williams D (1975) Combined immunosuppression and anacoagulation in rapidly progressive glomerulonephritis Lancet II: 923-925
35. Haycock G (1988) The treatment of glomerulonephritis in children. Pediatr Nephrol 2: 247-255
36. Robson A, Cole B, Kienstra R, Kissane J, Alkjaersig N, Fletcher A (1977) Severe glomerulonephritis complicated by coagulopathy: treatment with anticoagulant and immunosuppressive drugs. J Pediatr 90: 881-892
37. Savage J, Postlethwaite R, Lendon M, Houston I, Evans D (1982) Combined immunosuppressive and anticoagulant treatment in children with glomerulonephritis and declining renal function. Int J Pediatr Nephrol 3: 167-174
38. Srivastrava R, Choudry V (1980) Rapidly progressive (crescentic) glomerulonephritis. Int J Pediatr Nephrol 1: 94-96
39. Leititis JU, Brandis M (1992) Critical care in uraemic children. Pediatr Nephrol 6: 88-95
40. Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L (1992) Maturation of the hemostatic system during childhood. Blood 80: 1998-2005
41. Andrew M, Castle V, Mitchell L, Paes B (1989) A modified bleeding time in the infant. Am J Hematol 30: 190-191
42. Bowker J, Andrew M, Paes B (1990) Assessing bleeding disorders in the newborn. Can J Diagn 149-164
43. Feusner JH (1980) Normal and abnormal bleeding times in neonates and young children utilizing a fully standardized template technique. Am J Clin Pathol 74: 73-77
44. Fabris F, Cordiano I, Randi ML, Casonato A, Montini G (1991) Effect of human recombinant erythropoietin on bleeding time, platelet number and function in children with end-stage renal disease maintained by haemodialysis, Pediatr Nephrol 5: 225-228
45. Sloand EM, Sloand JA, Prodouz K, Klein HG, Harvath L, Fricke W (1991) Reduction of platelet glycoprotein Ib in uraemia. Br J Haematol 77: 375-381
46. Eberst M, Berkowitz L (1994) Hemostasis in renal disease: pathophysiology and management. Am J Med 96: 168-178
47. Gralnick H, McKeown L, Williams S, Shafer B, Pierce L (1988) Plasma and platelet von-Willebrand factor in uremia. Am J Med 85: 806-810
48. Kazatchkine M, Sultan Y, Caen J, Bariety J (1976) Bleeding in renal failure: a possible cause. BMJ 2: 612-615
49. Remuzzi G (1990) Bleeding disorders in uremia: pathophysiology and treatment. Adv Nephrol 18: 171-186
50. Gralnick HR, McKeown LP, Williams SB, Shafer BC (1988) Plasma and platelet von Willebrand factor defects in uremia. Am J Med 85: 806-810
51. Janson PA, Jubelirer SJ, Weinstein MJ, Deykin D (1980) Treatment of the bleeding tendency in uremia with cryoprecipitate. N Engl J Med 303: 1318-1322
52. Mannucci PM, Remuzzi G, Pusineri F, Lombardi R, Valsecchi C, Mecca G, Zimmerman TS (1983) Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med 308: 8-12
53. Vigano G, Gaspari F, Locatelli M, Pusineri F, Bonati M, Remuzzi G (1988) Dose-effect and pharmacokinetics of estrogens given to correct bleeding time in uremia. Kidney Int 34: 853-858
54. Vigano G, Mannucci PM, Lattuada A, Harris A, Remuzzi G (1989) Subcutaneous desmopressin (DDAVP) shortens the bleeding time in uremia. Am J Hematol 31: 32-35
55. Remuzzi G, Pusineri F (1988) Coagulation defects in uremia. Kidney Int 33 [Suppl 24]: S13-S17
56. McFarland JG, Aster RH, Bussel JB, Gianopoulos JG, Derbes RS, Newman PJ (1991) Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele-specific oligonucleotide probes. Blood 78: 2276-2282
57. Eknoyan G, Wacksman S, Glueck H, Will J (1969) Platelet function in renal failure. N Engl J Med 280: 677-681
58. Larsson S, Hedner U, Nilsson I (1971) On coagulation and fibrinolysis in uraemic patients on maintenance haemodialysis. Acta Med Scand 189: 443-451
59. Delorme M, Saeed N, Sevcik A, Mitchell L, Berry L, Johnston M, Andrew M (1993) Plasma dermatan sulfate proteoglycan in a patient on chronic hemodialysis. Blood 82: 3380-3385
60. Fernandez F, Goudable C, Sie P, Ton-That H, Durand D, Suc JM, Boneu B. Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusions. Br J Haematol 59 (1) 139-148, 1985
61. Livio M, Marchesi D, Remuzzi G, Gotti E, Mecca G, de Gaetano G (1982) Uraemic bleeding: role of anaemia and beneficial effect of red cell transfusions. Lancet 2 (2306): 1013-1015
62. Cases A, Escolar G, Reverter JC, Ordinas A, Lopez-Pedret J, Revert L, Castillo R (1992) Recombinant human erythropoietin treatment improves platelet function in uremic patients. Kidney Int 42: 668-672
63. Nenci G, Berretine M, Agnelli G, Parice P, Bouncristiani W, Ballatori E (1979) Effect of peritoneal dialysis, hemodialysis, and kidney transplantation on blood platelet function. Nephron 23: 287-292
64. Pales JL, Lopez A, Asensio A, Merola E, Company X, Deulofeu R, Garcia M, Balague A (1987) Inhibitory effect of peak 2-4 of uremic middle molecules on platelet aggregation. Eur J Haematol 39: 197-202
65. Remuzzi G, Livio M, Marchiaro G, Mecca G, DeGaetano G (1978) Bleeding in renal failure: altered platelet function in chronic uremia only partially corrected by hemodialysis Nephron 22: 347-353
66. Abman SH (1994) Pathogenesis and treatment of neonatal and postnatal pulmonary hypertension (Review) Curr Opinion Pediatr 6 (3): 239-247
67. Finer NN, Etches PC, Kamstra B, Tierney AJ, Peliowski A, Ryan CA (1994) Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose response. J Pediatr 124, 302-308
68. Kinsella JP, Neish SR, Ivy DD, Shaffer E, Abman SH (1993) Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide. J Pediatr 123: 103-108
69. Remuzzi G, Perico N, Zoja C, Macconi D, Vigano G (1990) Role of endothelium-derived nitric oxide in the bleeding tendency of uremia. J Clin Invest 86: 1768-1771
70. Geary DF, Gajaria M, Fryer-Keene S, Willumsen J (1991) Low-dose and heparin-free hemodialysis in children. Pediatr Nephrol 5: 220-224
71. Borm J, Krediet R, Sturk A, Cate J ten (1986) Heparin versus low molecular weight heparin K2165 in chronic hemodialysis patients: a randomized cross-over study. Haemostasis 16: 59-68
72. Lane D, Flynn A, Ireland H, Anastassiades E, Curtis J (1986) On the evaluation of heparin and low-molecular-weight heparin in hemodialysis tor chronic renal failure. Haemostasis 16 [Suppl 2]: 38-47 (Abstract)
73. Wessler S, Reimer S, Sheps M (1959) Biological assay of a thrombosis inducing activity in human serum. J Appl Physiol 14: 943-946
74. Abejo RC, John EG, Spigos DG (1985) Low-dose streptokinase-induced clot lysis of an occluded arteriovenous fistula. J Pediatr 106: 321-323
75. Rodkin RS, Bookstein JJ, Heeney DJ, Davis GB (1983) Streptokinase and transluminal angioplasty in the treatment of acutely thrombosed hemodialysis access fistulas. Radiology 149: 425-428
76. Young AT, Hunter DW, Castaneda-Zuniga WR, So SKS, Mercado S, Cardella JF, Amplaz K (1985) Thrombosed synthetic hemodialysis access fistulas: failure of fibrinolytic therapy. Radiology 154: 639-642
77. Churchill BM, Sheldon CA, McLorie GA, Arbus GS (1988) Factors influencing patient and graft survival in 300 cadaveric pediatric renal transplants. J Urol 140: 1129-1133
78. Broyer M (1989) Kidney transplantation in children-data from the EDTA registry. Transplant Proc 21: 1985-1988
79. Broyer M, Mitsioni A, Gagnadoux MF, Fischer AM, Beurton D, Niaudet P, Habib R (1993) Early failures of kidney transplantation: a study of 70 cases from 801 consecutive grafts performed in children and adolescents. Adv Nephrol 22: 169
80. Harmon WE, Stablein D, Alexander SR, Tejani A (1991) Graft thrombosis in pediatric renal transplant recipients. Transplantation 51: 406-412
81. Kalicinski P, Kaminski A, Prokural A, Grenda R, Smirska E, Chrupek M, Szymczak M, Drewniak T, Ishmail H (1994) Surgical complications after kidney transplantation in children. Transplant Proc 26: 42-43
82. Sheldon CA, Churchill BM, McLorie GA, Arbus GS (1992) Evaluation of factors contributing to mortality in pediatric renal transplant recipients. J Pediatr Surg 27: 629-633
83. Valdes R, Munoz R, Bracho E, Gordillo G, Velazquez L, Nieto J (1994) Surgical complications of renal transplantation in malnourished children. Transplant Proc 26: 50-51
84. McEnery PT, Stablein DM, Arbus G, Tejani A (1992) Renal transplantation in children. A report of the North American Pediatric Renal Transplant Cooperative Study. N Engl J Med 326: 1727-1732
85. Andrew M, Berube C, Adams M, Vegh P (1995) The relationship between non-specific inhibitors in children with systemic lupus erythematosus and thromboembolic complications: a cross-sectional study. Lupus 3 (4): 360 Abstr 190, August 1994
86. Montes de Oca MA, Babron MC, Bletry O, Broyer M, Courtecuisse V, Fontaine JL, Loirat C, Mery JP, Reinen P, Wechsler B, Levy M (1991) Thrombosis in systemic lupus erythematosus: a French collaborative study. Arch Dis Child 66: 713-717
87. Lam AH, Shulman LA (1985) Ultrasound in congenital haemorrhage secondary to isoimmune thrombocytopenia. Pediatr Radiol 15: 8-11
88. Nuss R, Hays T, Manco-Johnson M (1994) Efficacy and safety of heparin anticoagulation for neonatal renal vein thrombosis. Am J Pediatr Hematol Oncol 16: 127-131
89. Van Damme-Lombaerts R, Proesmans W, Van Damme B, Eeckels R, Binda Ri Mucka P, Mercieca V, Vletinck R, Vermylen J (1988) Heparin plus dipyridamole in childhood hemolytic-uremic syndrome: a prospective, randomized study. J Pediatr 113: 913-918
90. Zobel G, Trop M, Muntean W, Ring E, Gleispach H (1988) Anticoagulation for continuous arteriovenous hemofiltration in children. Blood Purif 6: 90-95
91. Casu B, Oreste P, Torri G (1981) The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Biochem J 197: 599-609
92. Choay J, Lormeau JC, Petitou M, Sinay P, Fareed J (1981) Structural studies on a biologically active hexasaccharide obtained from heparin. Ann NY Acad Sci 370: 644-649
93. Hirsh J (1991) Heparin. N Engl J Med 324: 1565-1574
94. Levine MN, Hirsh J (1986) Hemorrhagic complications of anticoagulant therapy. Semin Thromb Haemost 12: 39-57
95. Nieuwenhuis HK, Albada J, Banga JD, Sixma JJ (1991) Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin. Blood 78: 2337-2343
96. Shojania A, Tetreault J, Turnbull G (1988) The variations between heparin sensitivity of different lots of activated partial thromboplastin time reagent produced by the same manufacturer. Am J Clin Pathol 89: 19-23
97. Refn I, Vestergaard L (1954) The titration of heparin with protamine. Scand J Clin Lab Invest 6: 284-287
98. Teien AN, Lie M (1977) Evaluation of amidolytic heparin assay method. Increased sensitivity by adding purified antithrombin III. Thromb Res 10: 399-410
99. Chiu H, Hirsh J, Yung W, Regoeczi E, Gent M (1977) Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis. Blood 49: 171-184
100. Levine M, Hirsh J, Gent M, Turpie A, Cruickshank M, Anderson D, Johnston M (1995) A randomized trial comparing the activated thromboplastin time with the heparin assay to monitor heparin therapy in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Intern Med (in press)
101. Gillies H, Rogers HJ, Johnston J, Harper PG, Rudge CJ (1985) Is repeated flushing of Hickman catheters necessary? BMJ 290: 1708
102. Lombardi TP, Gundersen B, Zammett LO, Walters JK, Morris B (1988) Efficacy of 09% sodium chloride injection with or without heparin sodium for maintaining patency of intravenous catheters in children. Clin Pharm 7: 832-836
103. Smith SM, Dawson SM, Hennessey R, Andrew M (1991) Maintenance of the patency of indwelling central venous catheters: is heparin necessary. Am J Pediatr Hematol Oncol 13. 141-143
104. Bern MM, Lokich JJ, Wallach SR, Bothe AJ, Benotti PN, Arkin CF, Greco FA, Huberman M, Moore C (1990) Very low doses of warfarin can prevent thrombosis in central venous catheters. A randomized prospective trial. Ann Intern Med 112: 423-428
105. Andrew M Marzinotto V Blanchette V Ginsberg J Burrows P Benson L Williams W David M Poon A Sparling C Heparin therapy in pediatric patients: A prospective cohort study. Pediatr Res 35: 78-83
106. Cruickshank M, Levine M, Hirsh J, Roberts R, Siguenza M (1991) A standard heparin nomogram for the management of heparin therapy. Arch Intern Med 151: 333-337
107. Andrew M, Ofosu F, Schmidt B, Brooker L, Hirsh J, Buchanan M (1988) Heparin clearance and ex vivo recovery in newborn piglets and adult pigs. Thromb Res 52: 517-527
108. McDonald MM, Jacobson LJ, Hay WW, Hathaway WE (1981) Heparin clearance in the newborn. Pediatr Res 15: 1015-1018
109. Turner Gomes S, Nitschmann E, Benson L, Burrows P, Andrew M (1993) Heparin is cleared faster in children with congenital heart disease than adults. J Am Coll Cardiol 21: 59a (Abstract)
110. Basu D, Gallus A, Hirsh J, Cade J (1972) A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. N Engl J Med 287: 324-327
111. Hull R, Raskob G, Hirsh J, et al (1986) Continuous intravenous heparin compared to intermittent subcutaneous heparin in the initial treatment of proximal vein thrombosis. N Engl J Med 315: 1109-1114
112. Kaplan K, Davison R, Parker M, Mayberry B, Feiereisel P, Salinger M (1987) Role of heparin after intravenous thrombolytic therapy for acute myocardial infarction. Am J Cardiol 59: 241-244
113. Turpie A, Robinson J, Doyle D (1989) Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. N Engl J Med 320: 352-357
114. Hirsh J (1991) Oral anticoagulant drugs. Review article. N Engl J Med 324: 1865-1875
115. Quick AJ, Grossman AM (1939) Prothrombin concentration in newborns. Proc Soc Exp Biol Med 41: 227
116. International Committee for Standardization in Haematology; International Committee on Thrombosis and Haemostasis (1985) ICSH/ICTH Recommendations for reporting prothrombin time in oral anticoagulant control. Thromb Haemost 53: 155-156
117. Loeliger E, Besselaar A van den, Lewis S (1985) Reliability and clinical impact of the normalization of the prothrombin times in oral anticoagulant control. Thromb Haemost 53 (1): 148-154
118. Poller L (1987) Laboratory control of oral anticoagulants. BMJ 294: 1184
119. Poller L (1987) Progress in standardization anticoagulation control. Hematol Rev 1: 225-241
120. Roy A, Jaffe N, Djerassi I (1973) Prophylactic platelet transfusions in children with acute leukemia: a dose response study. Transfusion 13: 283
121. Hirsh J, Poller L, Deykin D, Levine M, Dalen JE (1989) Optimal therapeutic range for oral anticoagulants. Chest 95: 5S-11S
122. Kumar S, Haigh J, Rhodes L, Peaker S, Davies J, Roberts B, Feely M (1989) Poor compliance is a major factor in unstable outpatient control of anticoagulant therapy. Thromb Haemost 62: 729-732
123. Stewart S, Cianciotta D, Alexson C, Manning J (1987) The long-term risk of warfarin sodium therapy and the incidence of thromboembolism in children after prosthetic cardiac valves. J Thorac Cardiovasc Surg 93: 551-554
124. Harada Y, Imai Y, Kurosawa H, et al (1990) Ten-year follow-up after valve replacement with the St Jude Medical prosthesis in children. J Thorac Cardiovasc Surg 100: 175-180
125. McGrath L, Gonzalez-Lavin L, Edlredge W, Colombi M, Restrepo D (1987) Thromboembolic and other events following valve replacement in a pediatric population treated with anti-platelet agents. Ann Thorac Surg 43: 285-287
126. Spevak P, Freed M, Castaneda A, et al (1986) Valve replacement in children less than 5 years of age. Am J Cardiol 8: 901-908
127. Woods A, Vargas J, Berri G, Kreutzer G, Meschengieser S, Lazzari MA (1986) Antithrombotic therapy in children and adolescents. Thromb Res 42: 289-301
128. Andrew M, Marzinotto V, Brooker L, Adams M, Ginsberg J, Freedom R, Williams W (1994) Oral anticoagulant therapy in pediatric patients: a prospective study. Thromb Haemost 71: 265-269
129. Bradley LM, Midgley FM, Watson DC, et al (1985) Anti-coagulation therapy in children with mechanical prosthetic cardiac valves. Am J Cardiol 56: 533-535
130. Carpentieri U, Nghiem QX, Harris LC (1976) Clinical experience with an oral anticoagulant in children. Arch Dis Child 51: 445-448
131. Doyle JJ, Koren G, Chen MY, Blanchette VS (1988) Anti-coagulation with sodium warfarin in children: effect of a loading regimen. J Pediatr 113: 1095-1097
132. Kellam B, Froze D, Kanarek K (1987) Clot lysis for thrombosed central venous catheters in pediatric patients. J Perinatol 7: 242-244
133. Mirro JJ, Rao BN, Stokes DC, Austin BA, Kumar M, Dabe GV, Colten M, Balas L, Rafferty M, Hancock M, Fairclough D (1989) A prospective study of Hickman/Broviac catheters and implantable ports in pediatric oncology patients. J Clin Oncol 7: 214-222
134. Morris J, Occhionero M, Gauderer M, et al (1990) Totally implantable vascular access devices in cystic fibrosis: a four-year experience with fifty-eight patients. J Pediatr 117: 82-85
135. Winthrop AL, Wesson DE (1984) Urokinase in the treatment of occluded central venous catheters in children J Pediatr Surg 19: 536-538