Adiposity and bone mineral density of Chilean elderly women in relation to toll-like receptor 4 gene polymorphisms

Annals of Human Biology

Volumn 33, Issue 5-6, 2006, Pages 585-592

  Santos, José Luis ^a   Lera, L ^a   Perez Bravo F ^a   Albala, C ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Elderly; Genetic; Obesity; Osteoporosis; Toll like receptor

Indexed keywords

TOLL LIKE RECEPTOR 4;

ALLELE; BONE; DISEASE; ELDERLY POPULATION; GENETICS; GENOTYPE; IMMUNE SYSTEM; IMMUNOASSAY; OBESITY; POLYMORPHISM; WOMENS HEALTH;

AGED; ARTICLE; BONE DENSITY; CHILE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; HUMAN; MIDDLE AGED; MORPHOMETRICS; OBESITY; RADIODENSITOMETRY;

ADIPOSITY; AGED; AGED, 80 AND OVER; BODY WEIGHTS AND MEASURES; BONE DENSITY; CHILE; DENSITOMETRY, X-RAY; FEMALE; GENE FREQUENCY; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC; TOLL-LIKE RECEPTOR 4;

CHILE; SOUTH AMERICA;

EID: 33847749978     PISSN: 03014460     EISSN: 14645033     Source Type: Journal    
DOI: 10.1080/03014460601011798     Document Type: Article

References (25)

1. Abraham LJ, Kroeger KM. 1999. Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: Relevance to disease. J Leukoc Biol 66:562-566.
2. Anderson KV, Bokla L, Nusslein-Volhard C. 1985. Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 42:791-798.
3. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. 2000. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187-191.
4. Chen HY, Chen WC, Hsu CM, Tsai FJ, Tsai CH. 2005. Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: Correlation to bone mineral density and susceptibility to osteoporosis. Eur J Obstet Gynecol Reprod Biol 122:73-78.
5. Cleves M. 1999. Hardy-Weinberg equilibrium test and allele frequency estimation. Stat Tech Bull 48:34-37. Devlin B, Risch N. 1995. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29:311-322.
6. Hotamisligil GS, Shargill NS, Spiegelman BM. 1993. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259:87-91.
7. Illig T, Bongardt F, Schopfer A, Holle R, Muller S, Rathmann W, Koenig W, Meisinger C, Wichmann HE, Kolb H, KORA Study Group. 2003. The endotoxin receptor TLR4 polymorphisms is not associated with diabetes or components of the metabolic syndrome. Diabetes 52:2861-2864.
8. Johnson GB, Riggs BL, Platt JL. 2004. A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones. FASEB J 18:1282-1284.
9. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. 2002. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347:185-192.
10. McCauley LK, Nohutcu RM. 2002. Mediators of periodontal osseous destruction and remodelling: Principles and implications for diagnosis and therapy. J Periodontol 73:1377-1391.
11. Mander AP. 2001. Haplotype analysis in population-based association studies. STATA J 1:58-75.
12. Michel O, LeVan TD, Stern D, Dentener M, Thorn J, Gnat D, Beijer ML, Cochaux P, Holt PG, Martinez FD, et al. 2003. Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings. J Allergy Clin Immunol 112:923-929.
13. Norman RA, Bogardus C, Ravussin E. 1995. Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest 96:158-162.
14. Patiño-García A, Sotillo-Piñeiro E, Modesto C, Sierrasesúmaga L. 1999. Screening of the tumor necrosis factor-alpha (TNF-α) gene promoter polymorphisms by PCR-DGGE analysis. Mut Res Genom 406:121-125.
15. Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R. 2001. Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci USA 98:13960-13965.
16. Santos JL, Pérez-Bravo F, Carrasco E, Calvillán M, Albala C. 2001. Association between type 1 diabetes and HLA-DQB1 alleles in a case-parents study conducted in Santiago, Chile. Am J Epidemiol 153:794-798.
17. Santos JL, Albala C, Lera L, García C, Arroyo P, Pérez-Bravo F, Angel B, Peláez M. 2004. Anthropometric measurements in the elderly population of Santiago, Chile. Nutrition 20:452-457.
18. Schmidt MI, Duncan BB. 2003. Diabesity: An inflammation metabolic condition. Clin Chem Lab Med 41:1120-1130.
19. Schork NJ, Nath SK, Fallin D, Chakravarti A. 2000. Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. Am J Hum Genet 67:1208-1218.
20. Schutz Y, Kyle UUG, Pichard C. 2002. Fat-free mass index and fat mass index percentiles in Caucasians aged 18-98 y. Int J Obesity 26:953-960.
21. Takeda K, Akira S. 2005. Toll-like receptors in innate immunity. Int Immunol 17:1-14.
22. Torok HP, Glas J, Tonenchi L, Mussack T, Folwaczny C. 2004. Polymorphisms of the lipopolysaccharide-signalling complex in inflammatory bowel disease: Association of a mutation in the toll-like receptor 4 gene with ulcerative colitis. Clin Immunol 112:85-91.
23. Van der Graaf C, Kullberg BJ, Joosten L, Verver-Jansen T, Jacobs L, Van der Meer JW, Netea MG. 2005. Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism. Cytokine 30:264-268.
24. Wilson AG, di Symons JA, McDowell TL, McDevitt HO, Duff GW. 1997. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3195-3199.
25. WHO. 1994. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organization Study Group, WHO Technical Report Series 843. Geneva.