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Volumn 17, Issue 3, 2007, Pages 351-356

Pyrazole trk kinase inhibitors for the treatment of cancer

Author keywords

NGF; Pyrazole; TrkA

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID DERIVATIVE; ANTINEOPLASTIC AGENT; CEP 2563; CEP 3555; CEP 701; CEP 751; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; ISOTHIAZOLE DERIVATIVE; OXINDOLE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE A; PROTEIN TYROSINE KINASE INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 33847743421     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.17.3.351     Document Type: Article
Times cited : (6)

References (33)
  • 2
  • 3
    • 0026766860 scopus 로고
    • The nerve growth factor family of receptors
    • MEAKIN SO, SHOOTER EM: The nerve growth factor family of receptors. Trends Neurosci. (1992) 15:323-331.
    • (1992) Trends Neurosci. , vol.15 , pp. 323-331
    • Meakin, S.O.1    Shooter, E.M.2
  • 4
    • 0025343230 scopus 로고
    • Signal transduction by receptor with tyrosine kinase activity
    • ULLRICH A, SCHLESSINGER J: Signal transduction by receptor with tyrosine kinase activity. Cell (1990) 61:203-212.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 5
    • 0025735392 scopus 로고
    • The trk proto-oncogene product: A signal transducing receptor for nerve growth factor
    • KAPLAN DR, HEMPSTEAD BL, MARTIN-ZANCA D, CHAO MV, PARADA LF: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science (1991) 252:554-558.
    • (1991) Science , vol.252 , pp. 554-558
    • Kaplan, D.R.1    Hempstead, B.L.2    Martin-Zanca, D.3    Chao, M.V.4    Parada, L.F.5
  • 6
    • 0028115022 scopus 로고
    • Neurotrophin signal transduction by the trk receptor
    • KAPLAN DR, STEPHENS MR: Neurotrophin signal transduction by the trk receptor. J. Neurobiol. (1994) 25:1404-1417.
    • (1994) J. Neurobiol. , vol.25 , pp. 1404-1417
    • Kaplan, D.R.1    Stephens, M.R.2
  • 7
    • 0019071287 scopus 로고
    • Physiology of nerve growth factor
    • THOENEN H, BARDE YA: Physiology of nerve growth factor. Physiol. Rev. (1980) 60:1284-1335.
    • (1980) Physiol. Rev. , vol.60 , pp. 1284-1335
    • Thoenen, H.1    Barde, Y.A.2
  • 8
    • 0342288702 scopus 로고
    • Pharmacology of neurotrophic factors in models of neurodegenerative diseases
    • DISTEFANO PS: Pharmacology of neurotrophic factors in models of neurodegenerative diseases. Annu. Rep. Med. Chem. (1993)28:11-17.
    • (1993) Annu. Rep. Med. Chem. , vol.28 , pp. 11-17
    • Distefano, P.S.1
  • 9
    • 0032877546 scopus 로고    scopus 로고
    • Role of neurotrophin-trk interactions in oncology: The anti-tumor efficacy of potent and selective rrk tyrosine kinase inhibitors in pre-clinical tumor models
    • RUGGERI BA, MIKNYOCZKI SJ, SINGH J, HUDKINS RL: Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective rrk tyrosine kinase inhibitors in pre-clinical tumor models. Curr. Med. Chem. (1999) 6:845-857.
    • (1999) Curr. Med. Chem. , vol.6 , pp. 845-857
    • Ruggeri, B.A.1    Miknyoczki, S.J.2    Singh, J.3    Hudkins, R.L.4
  • 10
    • 0030429531 scopus 로고    scopus 로고
    • Neurotrophin-trk receptor interactions in neoplasia: A possible role in interstitial and perineural invasion in ductal pancreatic cancer
    • MIKNYOCZKI SJ, KLEIN-SZANTO AJ, RUGGERI BA: Neurotrophin-trk receptor interactions in neoplasia: a possible role in interstitial and perineural invasion in ductal pancreatic cancer. Crit. Rev. Oncogen. (1996) 7:89-100.
    • (1996) Crit. Rev. Oncogen. , vol.7 , pp. 89-100
    • Miknyoczki, S.J.1    Klein-Szanto, A.J.2    Ruggeri, B.A.3
  • 11
    • 0032939723 scopus 로고    scopus 로고
    • Neurotrophins and trk receptors in human pancreatic ductal adrenocarcinoma: Expression patterns and effects on in vitro invasive behavior
    • MIKNYOCZKI SJ, LANG L, KLEIN-SZANTO AJ, DIONNE CA, RUGGERI BA: Neurotrophins and trk receptors in human pancreatic ductal adrenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int. J. Cancer (1999) 81:417-427.
    • (1999) Int. J. Cancer , vol.81 , pp. 417-427
    • Miknyoczki, S.J.1    Lang, L.2    Klein-Szanto, A.J.3    Dionne, C.A.4    Ruggeri, B.A.5
  • 12
    • 0036284490 scopus 로고    scopus 로고
    • The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenographs in nude mice
    • MIKNYOCZKI SJ, WAN W, CHANG H et al.: The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenographs in nude mice. Clin. Cancer Res. (2002) 8:1924-1931.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1924-1931
    • Miknyoczki, S.J.1    Wan, W.2    Chang, H.3
  • 13
    • 0028851242 scopus 로고
    • Expression of a high affinity nerve growth factor receptor in the human prostate
    • PFLUG BR, DIONNE CA, KAPLAN DR, LYNCH J, DJAKIEW D: Expression of a high affinity nerve growth factor receptor in the human prostate. Endocrinology (1995) 136:262-268.
    • (1995) Endocrinology , vol.136 , pp. 262-268
    • Pflug, B.R.1    Dionne, C.A.2    Kaplan, D.R.3    Lynch, J.4    Djakiew, D.5
  • 15
    • 0034007078 scopus 로고    scopus 로고
    • Nerve growth factor cooperates with p185(HER2) in activating growth of human breast carcinoma cells
    • TAGLIABUE E, CASTIGLIONI F, GHIRELLI C et al.: Nerve growth factor cooperates with p185(HER2) in activating growth of human breast carcinoma cells. J. Biol. Chem. (2000) 275:5388-5394.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5388-5394
    • Tagliabue, E.1    Castiglioni, F.2    Ghirelli, C.3
  • 16
    • 19044391610 scopus 로고    scopus 로고
    • Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
    • TOGNON C, KNEZEVICH SR, HUNTSMAN D et al.: Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell (2002) 2:367-376.
    • (2002) Cancer Cell , vol.2 , pp. 367-376
    • Tognon, C.1    Knezevich, S.R.2    Huntsman, D.3
  • 17
    • 0037500963 scopus 로고    scopus 로고
    • Expression and activation of the nerve growth factor receptor trkA in serous ovarian carcinoma
    • DAVIDSON B, REICH R, LAZAROVICI P: Expression and activation of the nerve growth factor receptor trkA in serous ovarian carcinoma. Clin. Cancer Res. (2003) 9:2248-2259.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2248-2259
    • Davidson, B.1    Reich, R.2    Lazarovici, P.3
  • 18
    • 0038670241 scopus 로고    scopus 로고
    • Mutational analysis of the tyrosine kinome in colorectal cancers
    • BARDELLI, A, PARSONS DW, SILLIMAN N et al.: Mutational analysis of the tyrosine kinome in colorectal cancers. Science (2003) 300:949.
    • (2003) Science , vol.300 , pp. 949
    • Bardelli, A.1    Parsons, D.W.2    Silliman, N.3
  • 20
    • 0028945672 scopus 로고
    • The role of trophic factors and autocrine/paracrine growth factors in brain marastasis
    • MENTER DG, HERRMANN JL, NICOLSON GL: The role of trophic factors and autocrine/paracrine growth factors in brain marastasis. Clin. Exp. Metastasis (1995) 13:67-88.
    • (1995) Clin. Exp. Metastasis , vol.13 , pp. 67-88
    • Menter, D.G.1    Herrmann, J.L.2    Nicolson, G.L.3
  • 21
    • 0028679238 scopus 로고
    • Tumor metastasis to brain: Role of endothelial cells, neurotrophins and paracrine growth factors
    • NICOLSON GL, MENTERDG, HERRMANN JL et al.: Tumor metastasis to brain: role of endothelial cells, neurotrophins and paracrine growth factors. Crit. Rev. Oncol. (1994) 5:451-471.
    • (1994) Crit. Rev. Oncol. , vol.5 , pp. 451-471
    • Nicolson, G.L.1    Menterdg2    Herrmann, J.L.3
  • 22
    • 0025895786 scopus 로고
    • Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate
    • DJAKIEW D, DELSITE R, PFLUG B et al.: Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate. Cancer Res. (1991) 51:3304.
    • (1991) Cancer Res. , vol.51 , pp. 3304
    • Djakiew, D.1    Delsite, R.2    Pflug, B.3
  • 23
    • 0034881357 scopus 로고    scopus 로고
    • Pan-trk inhibition decreases metastasis and enhances host survival in experimental models due to its selective induction of apoptosis of prostate cancer cell
    • WEERARATNA AT, DALRYMPLE SL, LAMB JC: Pan-trk inhibition decreases metastasis and enhances host survival in experimental models due to its selective induction of apoptosis of prostate cancer cell. Clin. Cancer Res. (2001)7:2237-2245.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2237-2245
    • Weeraratna, A.T.1    Dalrymple, S.L.2    Lamb, J.C.3
  • 24
    • 0030002415 scopus 로고    scopus 로고
    • Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity
    • ANGELES TS, STEFFLER C, HUDKINS RL et al.: Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity. Anal. Biochem. (1996) 206:49-55.
    • (1996) Anal. Biochem. , vol.206 , pp. 49-55
    • Angeles, T.S.1    Steffler, C.2    Hudkins, R.L.3
  • 26
    • 0031872458 scopus 로고    scopus 로고
    • Cell cycle independent-death of prostate adenocarcinoma is induced by trk tyrosine kinase inhibitor CEP-751 (KT6587)
    • DIONNE C, CAMORATTO A, JANI J et al.: Cell cycle independent-death of prostate adenocarcinoma is induced by trk tyrosine kinase inhibitor CEP-751 (KT6587). Clin. Cancer Res. (1998) 4:1887-1898.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1887-1898
    • Dionne, C.1    Camoratto, A.2    Jani, J.3
  • 27
    • 0030874174 scopus 로고    scopus 로고
    • CEP-751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity
    • CAMORATTO AM, JANI J, ANGELES TS et al.: CEP-751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity. Int. J. Cancer (1997) 72:673-679.
    • (1997) Int. J. Cancer , vol.72 , pp. 673-679
    • Camoratto, A.M.1    Jani, J.2    Angeles, T.S.3
  • 28
    • 10244241837 scopus 로고    scopus 로고
    • Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors
    • UNDEVIA SD, VOGELZANG NJ MAUER AM, JANISCH L, MANI S, RATAIN MJ: Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors. Invest. New Drugs (2004) 22:449-458.
    • (2004) Invest. New Drugs , vol.22 , pp. 449-458
    • Undevia, S.D.1    Vogelzang, N.J.2    Mauer, A.M.3    Janisch, L.4    Mani, S.5    Ratain, M.J.6
  • 29
    • 20844444589 scopus 로고    scopus 로고
    • Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor
    • MARSHALL JL, KINDLER H, DEEKEN J: Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor. Invest. New Drugs (2005) 23:31-7.
    • (2005) Invest. New Drugs , vol.23 , pp. 31-37
    • Marshall, J.L.1    Kindler, H.2    Deeken, J.3
  • 30
    • 0032771840 scopus 로고    scopus 로고
    • The trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma
    • MIKNYOCZKI SJ, CHANG H, KLEIN-SZANTO AJ, DIONNE CA, RUGGERI BA: The trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma. Clin. Cancer Res. (1999) 5:2205-2212.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2205-2212
    • Miknyoczki, S.J.1    Chang, H.2    Klein-Szanto, A.J.3    Dionne, C.A.4    Ruggeri, B.A.5
  • 31
    • 0033563119 scopus 로고    scopus 로고
    • Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and trk tyrosine kinase inhibitors. CEP-751 (KT-6587) or CEP-701 (KT-5555)
    • GEORGE DJ, DIONNE CA, JANI J et al.: Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and trk tyrosine kinase inhibitors. CEP-751 (KT-6587) or CEP-701 (KT-5555). Cancer Res. (1999) 59:2395-2401.
    • (1999) Cancer Res. , vol.59 , pp. 2395-2401
    • George, D.J.1    Dionne, C.A.2    Jani, J.3
  • 32
    • 20144381281 scopus 로고    scopus 로고
    • Synthesis, modeling and in vitro activity of 3′-(S)-epi-K-252a analogs. Elucidating the stereochemical requirements of the 3′-sugar alcohol on trkA tyrosine kinase activity
    • GINGRICH DL, ANGELES TS, HUDKINS RL et al.: Synthesis, modeling and in vitro activity of 3′-(S)-epi-K-252a analogs. Elucidating the stereochemical requirements of the 3′-sugar alcohol on trkA tyrosine kinase activity. J. Med. Chem. (2005) 48:3776-3783.
    • (2005) J. Med. Chem. , vol.48 , pp. 3776-3783
    • Gingrich, D.L.1    Angeles, T.S.2    Hudkins, R.L.3
  • 33
    • 0037152506 scopus 로고    scopus 로고
    • Synthesis and kinase inhibitory activity of Med. Chem. Lett. 3′-(S)-epi-K-252a
    • GINGRICH DL, HUDKINS RL: Synthesis and kinase inhibitory activity of Med. Chem. Lett. 3′-(S)-epi-K-252a. Bioorg. (2002) 12:2829-2831.
    • (2002) Bioorg. , vol.12 , pp. 2829-2831
    • Gingrich, D.L.1    Hudkins, R.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.