Changes in 2-hydroxyestrone and 16α-hydroxyestrone metabolism with flaxseed consumption: Modification by COMT and CYP1B1 genotype

Cancer Epidemiology Biomarkers and Prevention

Volumn 16, Issue 2, 2007, Pages 256-262

  McCann, Susan E ^a,g   Wactawski Wende, Jean ^a   Kufel, Kari ^b   Olson, James ^c   Ovando, Bladimir ^c   Kadlubar, Susan Nowell ^d   Davis, Warren ^a   Carter, Lisa ^a   Muti, Paola ^e   Shields, Peter G ^f   Freudenheim, Jo L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c NEW YORK STATE DEPARTMENT OF HEALTH   (United States)

^d UNIVERSITY OF ARKANSAS AT LITTLE ROCK   (United States)

^e REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^f GEORGETOWN UNIVERSITY   (United States)

^g ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA HYDROXYESTRONE; 2 HYDROXYESTRONE; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450 1B1; LEUCINE; METHIONINE; VALINE;

ADULT; AGED; ALLELE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIETARY INTAKE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HORMONE METABOLISM; HUMAN; HUMAN EXPERIMENT; LINSEED; POSTMENOPAUSE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; URINALYSIS;

AGED; ARYL HYDROCARBON HYDROXYLASES; CATECHOL O-METHYLTRANSFERASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLAX; GENOTYPE; HUMANS; HYDROXYESTRONES; INTERVENTION STUDIES; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POSTMENOPAUSE; STATISTICS, NONPARAMETRIC;

EID: 33847738093     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-06-0633     Document Type: Article

References (35)

1. Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. Role of exogenous and endogenous hormones in endometrial cancer: review of the evidence and research perspectives. Ann N Y Acad Sci 2001;943:296-315.
2. Persson I. Estrogens in the causation of breast, endometrial, and ovarian cancers - evidence and hypotheses from epidemiological findings. J Steroid Biochem Mol Biol 2000;74:357-64.
3. Garcia-Closas R, Castellsague X, Bosch X, Gonzalez CA. The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int J Cancer 2005;117:629-37.
4. Mitrunen K, Hirvonen A. Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. Mutat Res 2003;544:9-41.
5. Lord RS, Bongiovanni B, Bralley JA. Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites. Altern Med Rev 2002;7:112-29.
6. Paracchini V, Pedotti P, Raimondi S, et al. A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med 2005;43:702-6.
7. CYP1B1 Single Nucleotide Polymorphism report [2006]. NCBI SNP Database. Available from: http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1056836.
8. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243-50.
9. Dawling S, Hachey DL, Roodi N, Parl FF. In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol. Chem Res Toxicol 2004;17:1258-64.
10. Webb AL, McCullough ML. Dietary lignans: potential role in cancer prevention. Nutr Cancer 2005;51:117-31.
11. Brooks JD, Ward WE, Lewis JE, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr 2004;79:318-25.
12. Haggans CJ, Hutchins AM, Olson BA, Thomas W, Martini MC, Slavin JL. Effect of flaxseed consumption on urinary estrogen metabolites in postmenopausal women. Nutr Cancer 1999;33:188-95.
13. Hutchins AM, Martini MC, Olson BA, Thomas W, Slavin JL. Flaxseed consumption influences endogenous hormone concentrations in postmenopausal women. Nutr Cancer 2001;39:58-65.
14. Kocabas NA, Sardas S, Cholerton S, Daly AK, Karakaya AE. Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population. Arch Toxicol 2002;76:643-9.
15. Nutritionist Pro Nutrient Analysis software. First DataBank. San Bruno (CA); 2003.
16. U.S. Department of Agriculture, Agricultural Research Service, 2005. USDA National Nutrient Database for Standard Reference, Release 18. Nutrient Data Laboratory. Available from: http://www.nal.usda.gov/fnic/foodcomp.
17. Dai Q, Franke AA, Jin F, et al. Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai. Cancer Epidemiol Biomarkers Prev 2002;11:815-21.
18. den Tonkelaar I, Keinan-Boker L, Veer PV, et al. Urinary phytoestrogens and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 2001;10:223-8.
19. Hulten K, Winkvist A, Lenner P, Johansson R, Adlercreutz H, Hallmans G. An incident case-referent study on plasma enterolactone and breast cancer risk. Eur J Nutr 2002;41:168-76.
20. Ingram D, Sanders K, Kolybaba M, Lopez D. Case-control study of phytooestrogens and breast cancer. Lancet 1997;350:990-4.
21. Keinan-Boker L, van der Schouw YT, Grobbee DE, Peeters PH. Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr 2004;79:282-8.
22. Kilkkinen A, Virtamo J, Vartiainen E, et al. Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study. Int J Cancer 2004;108:277-80.
23. Linseisen J, Piller R, Hermann S, Chang-Claude J. Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. Int J Cancer 2004;110:284-90.
24. McCann SE, Muti P, Vito D, Edge SB, Trevisan M, Freudenheim JL. Dietary lignan intakes and risk of pre- and postmenopausal breast cancer. Int J Cancer 2004;111:440-3.
25. Pietinen P, Stumpf K, Mannisto S, Kataja V, Uusitupa M, Adlercreutz H. Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev 2001;10:339-44.
26. Zeleniuch-Jacquotte A, Adlercreutz H, Shore RE, et al. Circulating enterolactone and risk of breast cancer: a prospective study in New York. Br J Cancer 2004;91:99-105.
27. Nowell SA, Ahn J, Ambrosone CB. Gene-nutrient interactions in cancer etiology. Nutr Rev 2004;62:427-38.
28. Low YL, Taylor JI, Grace PB, et al. Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions. Cancer Epidemiol Biomarkers Prev 2005;14:213-20.
29. Low YL, Taylor JI, Grace PB, et al. Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men. J Nutr 2005;135:2680-6.
30. Hall WL, Vafeiadou K, Hallund J, et al. Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2005;82:1260-8.
31. McCann SE, Moysich KB, Freudenheim JL, Ambrosone CB, Shields PG. The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. J Nutr 2002;132:3036-41.
32. Piller R, Verla-Tebit E, Wang-Gohrke S, Linseisen J, Chang-Claude J. CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans. J Nutr 2006;136:1596-603.
33. Ahn J, Gammon MD, Santella RM, et al. Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use. Am J Epidemiol 2005;162:943-52.
34. Ahn J, Gammon MD, Santella RM, et al. Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk. Cancer Res 2004;64:7634-9.
35. Feigelson HS, Kean-Cowdin R, Pike MC, et al. Cytochrome P450c17α gene (CYP17) polymorphism predicts use of hormone replacement therapy. Cancer Res 1999;59:3908-10.