Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells

Biochemical Journal

Volumn 402, Issue 2, 2007, Pages 397-403

  Makise, Masaki ^a   Takahashi, Naoko ^b   Matsuda, Kazuya ^a   Yamairi, Fumiko ^a   Suzuki, Keitarou ^a   Tsuchiya, Tomofusa ^b   Mizushima, Tohru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

DNA replication; Orc4p; Orc5 ap; Origin recognition complex (ORC); Walker A motif; Yeast

Indexed keywords

DNA REPLICATION; ORC4P; ORC5-AP; ORIGIN RECOGNITION COMPLEX (ORC); WALKER A MOTIF;

BIOASSAY; CHROMOSOMES; DEFECTS; ENZYME INHIBITION; PROTEINS; YEAST;

DNA SEQUENCES;

ORIGIN RECOGNITION COMPLEX; PROTEASOME; PROTEIN ORC4P; PROTEIN ORC5 A; PROTEIN ORC5P; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; ORC4 PROTEIN, S CEREVISIAE; ORC5 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; HIGH TEMPERATURE; IMMUNOPRECIPITATION; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; TWO HYBRID SYSTEM; YEAST CELL; BINDING SITE; CELL CYCLE; CYTOLOGY; DRUG ANTAGONISM; GENETICS; METABOLISM; MUTATION; SACCHAROMYCES CEREVISIAE; TEMPERATURE;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; BINDING SITES; CELL CYCLE; MUTATION; ORIGIN RECOGNITION COMPLEX; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33847734266     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060841     Document Type: Article

References (36)

1. Sekimizu, K., Bramhill, D. and Kornberg, A. (1987) ATP activates DnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome. Cell 50, 259-265
2. Mizushima, T., Sasaki, S., Ohishi, H., Kobayashi, M., Katayama, T., Miki, T., Maeda, M. and Sekimizu, K. (1996) Molecular design of inhibitors of in vitro oriC DNA replication based on the potential to block the ATP binding of DnaA protein. J. Biol. Chem. 271, 25178-25183
3. Mizushima, T., Takaki, T., Kubota, T., Tsuchiya, T., Miki, T., Katayama, T. and Sekimizu, K. (1998) Site-directed mutational analysis for the ATP binding of DnaA protein. Functions of two conserved amino acids (Lys-178 and Asp-235) located in the ATP-binding domain of DnaA protein in vitro and in vivo. J. Biol. Chem. 273, 20847-20851
4. Katayama, T., Kubota, T., Kurokawa, K., Crooke, E. and Sekimizu, K. (1998) The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase. Cell 94, 61-71
5. Mizushima, T., Nishida, S., Kurokawa, K., Katayama, T., Miki, T. and Sekimizu, K. (1997) Negative control of DNA replication by hydrolysis of ATP bound to DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli. EMBO J. 16, 3724-3730
6. Makise, M., Mima, S., Tsuchiya, T. and Mizushima, T. (2001) Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids. J. Biol. Chem. 276, 7450-7456
7. Makise, M., Mima, S., Tsuchiya, T. and Mizushima, T. (2000) Identification of amino acids involved in the functional interaction between DnaA protein and acidic phospholipids. J. Biol. Chem. 275, 4513-4518
8. Makise, M., Mima, S., Katsu, T., Tsuchiya, T. and Mizushima, T. (2002) Acidic phospholipids inhibit the DNA-binding activity of DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli. Mol. Microbiol. 46, 245-256
9. Sekimizu, K. and Kornberg, A. (1988) Cardiolipin activation of DnaA protein, the initiation protein of replication in Escherichia coli. J. Biol. Chem. 263, 7131-7135
10. Xia, W. and Dowhan, W. (1995) In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92, 783-787
11. Bell, S. P. and Stillman, B. (1992) ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128-134
12. Klemm, R. D., Austin, R. J. and Bell, S. P. (1997) Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell 88, 493-502
13. Takenaka, H., Makise, M., Kuwae, W., Takahashi, N., Tsuchiya, T. and Mizushima, T. (2004) ADP-binding to origin recognition complex of Saccharomyces cerevisiae. J. Mol. Biol. 340, 29-37
14. Makise, M., Takenaka, H., Kuwae, W., Takahashi, N., Tsuchiya, T. and Mizushima, T. (2003) Kinetics of ATP-binding to origin recognition complex of Saccharomyces cerevisiae. J. Biol. Chem. 278, 46440-46445
15. Dutta, A. and Bell, S. P. (1997) Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13, 293-332
16. Takahashi, N., Yamaguchi, Y., Yamairi, F., Makise, M., Takenaka, H., Tsuchiya, T. and Mizushima, T. (2004) Analysis on origin recognition complex containing Orc5p with defective Walker A motif. J. Biol. Chem. 279, 8469-8477
17. Kimata, Y., Higashio, H. and Kohno, K. (2000) Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP. J. Biol. Chem. 275, 10655-10660
18. Estojak, J., Brent, R. and Golemis, E. A. (1995) Correlation of two-hybrid affinity data with in vitro measurements. Mol. Cell. Biol. 15, 5820-5829
19. Thomas, B. J. and Rothstein, R. (1989) Elevated recombination rates in transcriptionally active DNA. Cell 56, 619-630
20. Tone, Y. and Toh-E, A. (2002) Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Genes Dev. 16, 3142-3157
21. Scherer, S. and Davis, R. W. (1979) Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc. Natl. Acad. Sci. U.S.A. 76, 4951-4955
22. Longtine, M. S., McKenzie, III, A., Demarini, D. J., Shah, N. G., Wach, A., Brachat, A., Philippsen, P. and Pringle, J. R. (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961
23. Takahashi, N., Tsutsumi, S., Tsuchiya, T., Stillman, B. and Mizushima, T. (2002) Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro. J. Biol. Chem. 277, 16033-16040
24. Liang, C. and Stillman, B. (1997) Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 11, 3375-3386
25. Mizushima, T., Takahashi, N. and Stillman, B. (2000) Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev. 14, 1631-1641
26. Pickart, C. M. (2001) Ubiquitin enters the new millennium. Mol. Cell 8, 499-504
27. Coux, O., Tanaka, K. and Goldberg, A. L. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biocnem. 65, 801-847
28. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem. 67, 425-479
29. Wilkinson, K. D. (1995) Roles of ubiquitinylation in proteolysis and cellular regulation. Annu. Rev. Nutr. 15, 161-189
30. Saito, Y., Tsubuki, S., Ito, H. and Kawashima, S. (1990) The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12h cells. Neurosci. Lett. 120, 1-4
31. Jensen, T. J., Loo, M. A., Pind, S., Williams, D. B., Goldberg, A. L. and Riordan, J. R. (1995) Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83, 129-135
32. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature 340, 245-246
33. Prasanth, S. G., Prasanth, K. V. and Stillman, B. (2002) Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. Science 297, 1026-1031
34. Lee, D. G. and Bell, S. P. (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol. Cell. Biol. 17, 7159-7168
35. Kneissl, M., Putter, V., Szalay, A. A. and Grummt, F. (2003) Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J. Mol. Biol. 327, 111-128
36. Makise, M., Takenaka, H., Kuwae, W., Takahashi, N., Tsuchiya, T. and Mizushima, T. (2003) Kinetics of ATP binding to the origin recognition complex of Saccharomyces cerevisiae. J. Biol. Chem. 278, 46440-46445