Cortistatin-17 and -14 exert the same endocrine activities as somatostatin in humans

Growth Hormone and IGF Research

Volumn 14, Issue 5, 2004, Pages 382-387

  Gottero, C ^a   Prodam, F ^a   Destefanis, S ^a   Benso, A ^a   Gauna, C ^b   Me, E ^a   Filtri, L ^a   Riganti, F ^a   van der Lely, A J ^b   Ghigo, Ezio ^a   Broglio, F ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

ACTH; Cortisol; Cortistatin; GH; Ghrelin; GHRH; Glucose; Insulin; PRL; Somatostatin

Indexed keywords

CORTICOTROPIN; CORTISTATIN 14; CORTISTATIN 17; GHRELIN; GLUCOSE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HYDROCORTISONE; INSULIN; NEUROPEPTIDE; PROLACTIN; SOMATOSTATIN 14; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BODY MASS; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; FLUSHING; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; INCREASED APPETITE; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SIDE EFFECT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; ENDOCRINE SYSTEM; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; MALE; NEUROPEPTIDES; PEPTIDE HORMONES; PEPTIDES, CYCLIC; RATS; SOMATOSTATIN;

EID: 4444327154     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ghir.2004.04.003     Document Type: Article

References (30)

1. de Lecea L. Criado J.R. Prospero-Garcia O. et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties Nature 381 1996 242-245
2. de Lecea L. Ruiz-Lozano P. Danielson P.E. et al. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin Genomics 42 1997 499-506
3. Fukusumi S. Kitada C. Takekawa S. et al. Identification and characterization of a novel human cortistatin-like peptide Biochem. Biophys. Res. Commun. 232 1997 157-163
4. Spier A.D. de Lecea L. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions Brain Res. Brain Res. Rev. 33 2000 228-241
5. de Lecea L. del Rio J.A. Criado J.R. et al. Cortistatin is expressed in a distinct subset of cortical interneurons J. Neurosci. 17 1997 5868-5880
6. Dalm V.A. van Hagen P.M. van Koetsveld P.M. et al. Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system J. Clin. Endocrinol. Metab. 88 2003 270-276
7. Papotti M. Tarabra E. Allia E. et al. Presence of cortistatin in the human pancreas J. Endocrinol. Invest. 26 2003 RC15-RC18
8. Kreienkamp H.J. Molecular biology of the receptors for somatostatin and cortistatin Res. Probl. Cell Different 26 1999 215-237
9. Cone R.D. Low M.J. Elmquist J.K. Cameron J.L. Neuroendocrinology in: Larsen P.R. Reed P. Kronenberg H.M. Melmed S. Polomsky K.S. (Eds.) Williams Textbook of Endocrinology 10th ed. 2003 81-176 Elsevier Science Philadelphia
10. Siehler S. Seuwen K. Hoyer D. [125I]Tyr10-cortistatin14 labels all five somatostatin receptors Naunyn Schmiedebergs Arch. Pharmacol. 357 1998 483-489
11. Vasilaki A. Lanneau C. Dournaud P. de Lecea L. Gardette R. Epelbaum J. Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of sst2 somatostatin receptor subtype Neuroscience 88 1999 359-364
12. Sanchez-Alavez M. Gomez-Chavarin M. Navarro L. et al. Cortistatin modulates memory processes in rats Brain Res. 858 2000 78-83
13. Calbet M. Guadano-Ferraz A. Spier A.D. et al. Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate Brain Res. Mol. Brain Res. 72 1999 55-64
14. Robas N. Mead E. Fidock M. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion J. Biol. Chem. 278 2003 44400-44444
15. Deghenghi R. Papotti M. Ghigo E. Muccioli G. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland J. Endocrinol. Invest. 24 2001 RC1-RC3
16. Kojima M. Hosoda H. Kangawa K. Purification and distribution of ghrelin: the natural endogenous ligand for the growth hormone secretagogue receptor Horm. Res. 56 Suppl. 1 2001 93-97
17. Deghenghi R. Broglio F. Papotti M. Muccioli G. Ghigo E. Targeting the ghrelin receptor: orally active GHS and cortistatin analogs Endocrine 22 2003 13-18
18. Kojima M. Hosoda H. Date Y. Nakazato M. Matsuo H. Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656-660
19. Muccioli G. Tschop M. Papotti M. Deghenghi R. Heiman M. Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity Eur. J. Pharmacol. 440 2002 235-254
20. Broglio F. Gottero C. Benso A. et al. Ghrelin and the endocrine pancreas Endocrine 22 2003 19-24
21. Broglio F. Van Koetsveld P. Benso A. et al. Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans J. Clin. Endocrinol. Metab. 87 2002 4829-4832
22. Broglio F. Arvat E. Benso A. et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans J. Clin. Endocrinol. Metab. 87 2002 3783-3790
23. Benso A. Gottero C. Prodam F. et al. Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans J. Endocrinol. Invest. 26 2003 599-603
24. Deghenghi R. Avallone R. Torsello A. Muccioli G. Ghigo E. Locatelli V. Growth hormone-inhibiting activity of cortistatin in the rat J. Endocrinol. Invest. 24 2001 RC31-RC33
25. Kopchick J.J. Parkinson C. Stevens E.C. Trainer P.J. Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly Endocr. Rev. 23 2002 623-646
26. Barkan A.L. Dimaraki E.V. Jessup S.K. Symons K.V. Ermolenko M. Jaffe C.A. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels J. Clin. Endocrinol. Metab. 88 2003 2180-2184
27. Shimada M. Date Y. Mondal M.S. et al. Somatostatin suppresses ghrelin secretion from the rat stomach Biochem. Biophys. Res. Commun. 302 2003 520-525
28. Norrelund H. Hansen T.K. Orskov H. et al. Ghrelin immunoreactivity in human plasma is suppressed by somatostatin Clin Endocrinol (Oxf) 57 2002 539-546
29. Arosio M. Ronchi C.L. Gebbia C. Cappiello V. Beck-Peccoz P. Peracchi M. Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels J. Clin. Endocrinol. Metab. 88 2003 701-704
30. Broglio F. Benso A. Castiglioni C. et al. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects J. Clin. Endocrinol. Metab. 88 2003 1537-1542