Optimization of corticosteroid induced osteoporosis in ovariectomized sheep: A bone histomorphometric study

Veterinary and Comparative Orthopaedics and Traumatology

Volumn 20, Issue 1, 2007, Pages 18-23

  Bregger, M D Klopfenstein ^a,d   Schawalder, P ^b   Rahn, B ^a   Eckhardt, C ^a   Schneider, E ^a   Lill, C ^a,c  

^a AO RESEARCH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Orthopädie Bavariapark   (Germany)

^d NONE   (Switzerland)

Author keywords

Animal model; Bone histomorphometry; Corticosteroids; Osteoporosis; Sheep

Indexed keywords

ANIMALIA; OVIS ARIES;

EID: 33847712238     PISSN: 09320814     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616582     Document Type: Article

References (18)

1. Goltzman D. The contribution of basic science to the field of osteoporosis. Osteoporos Int 2000; Suppl. 2: S43.
2. Swiontkowski MF, Harrington RM, Keller TS et al. Torsion and bending analysis of internal fixation techniques for femoral neck fractures: the role of implant design and bone density. J Orthop Res 1987; 5:433-444.
3. Newman E, Turner AS, Wark JD. The potential of sheep for the study of osteopenia: current status and comparison with other animal models. Bone 1995; 16(4 Suppl): 277S-284S.
4. Pastoureau P, Arlot ME, Caulin F. Effects of oophorectomy on biochemical and histological indices of bone turnover in ewes. J Bone Miner Res 1989;4(Suppl. 1):58.
5. Chavassieux P, Pastoureau P, Chapuy MC et al. Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: a biochemical and histomorphometric study. Osteoporos Int 1993; 3: 97-102.
6. Chavassieux P, Buffet A, Vergnaud P et al. Short-term effects of corticosteroids on trabecular bone remodeling in old ewes. Bone 1997; 20:451-455.
7. Lill CA, Fluegel AK, Schneider E. Sheep model for fracture treatment in osteoporotic bone: a pilot study about different induction regimens. J Orthop Trauma 2000; 14: 559-565.
8. Lill CA, Gerlach UV, Eckhardt C et al. Bone changes due to glucocorticoid application in an ovariectomized animal model for fracture treatment in osteoporosis. Osteoporos Int 2002; 13: 407-414.
9. Lill CA, Fluegel AK, Schneider E. Effect of ovariectomy, malnutrition and glucocorticoid appli cation on bone properties in sheep: a pilot study. Osteoporos Int 2002; 13: 480-486.
10. Parfitt AM, Drezner MK, Glorieux FH et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987; 2: 595-610.
11. Lill CA, Winterstein E, Eckhardt C et al. Quantification of histomorphometric and structural bone changes in a sheep model for fracture treatment in osteoporotic bone. Vet Comp Orthop Traumatol 2003; 16: 243-249.
12. Dempster DW. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 1989; 4: 137-141.
13. Muller R, Van Campenhout H, Van Damme B et al. Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone 1998; 23: 59-66.
14. Chavassieux P, Garnero P, Duboeuf F et al. Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study. J Bone Miner Res 2001; 16: 89-96.
15. Lespessailles E, Roux JP, Benhamou CL et al. Fractal analysis of bone texture on os calcis radiographs compared with trabecular microarchitecture analyzed by histomorphometry. Calcif Tissue Int 1998; 63: 121-125.
16. Lespessailles E, Siroux V, Poupon S et al. Longterm corticosteroid therapy induces mild changes in trabecular bone texture. J Bone Miner Res 2000; 15: 747-753.
17. Selby PL, Halsey JP, Adams KR et al. Corticosteroids do not alter the threshold for vertebral fracture. J Bone Miner Res 2000; 15: 952-956.
18. Williamson LH. Caseous lymphadenitis in small ruminants. Vet Clin North Am Food Anim Pract 2001; 17: 359-371, VII.