Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft

Bone

Volumn 40, Issue 4, 2007, Pages 957-965

  Cooper, David M L ^a   Thomas, C David L ^b   Clement, John G ^b   Turinsky, Andrei L ^c   Sensen, Christoph W ^c   Hallgrímsson, Benedikt ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Aging; Cortical bone; Cortical porosity; Micro CT; Remodeling

Indexed keywords

ADULT; AGE; AGED; ANISOTROPY; ARTICLE; BODY HEIGHT; BODY SIZE; BODY WEIGHT; BONE REMODELING; BONE STRUCTURE; CORTICAL BONE; FEMALE; FEMUR; HUMAN; LIFESPAN; MALE; MICRO-COMPUTED TOMOGRAPHY; POROSITY; SEX DIFFERENCE; THREE DIMENSIONAL IMAGING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BODY WEIGHT; FEMALE; FEMUR; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MIDDLE AGED; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; SEX CHARACTERISTICS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33847698540     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.11.011     Document Type: Article

References (50)

1. Cohen J., and Harris W. The three-dimensional anatomy of haversian systems. J. Bone Jt. Surg., Am. 40A (1958) 419-434
2. Tappen NC. Three-dimensional studies of resorption spaces and developing osteons. Am. J. Anat. 149 (1977) 301-332
3. Stout S.D., Brunsden B.S., Hildebolt C.F., Commean P.K., Smith K.E., and Tappen N.C. Computer-assisted 3D reconstruction of serial sections of cortical bone to determine the 3D structure of osteons. Calcif. Tissue Int. 65 (1999) 280-284
4. Yeni Y.N., and Norman T.L. Fracture toughness of human femoral neck: effect of microstructure, composition, and age. Bone 26 (2000) 499-504
5. Currey J.D. The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone. J. Biomech. 21 (1988) 131-139
6. Martin R.B., and Ishida J. The relative effects of collagen fiber orientation, porosity, density, and mineralization on bone strength. J. Biomech. 22 (1989) 419-426
7. McCalden R.W., McGeough J.A., Barker M.B., and Court-Brown C.M. Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure. J. Bone Jt. Surg., Am. 75 (1993) 1193-1205
8. Schaffler M.B., and Burr DB. Stiffness of compact bone: effects of porosity and density. J. Biomech. 21 (1988) 13-16
9. Wang L., Fritton S.P., Cowin S.C., and Weinbaum S. Fluid pressure relaxation depends upon osteonal microstructure: modeling an oscillatory bending experiment. J. Biomech. 32 (1999) 663-672
10. Starkebaum W., Pollack S.R., and Korostoff E. Microelectrode studies of stress-generated potentials in four-point bending of bone. J. Biomed. Mater. Res. 13 (1979) 729-751
11. Bousson V., Peyrin F., Bergot C., Hausard M., Sautet A., and Laredo J.D. Cortical bone in the human femoral neck: three-dimensional appearance and porosity using synchrotron radiation. J. Bone Miner. Res. 19 (2004) 794-801
12. Cooper D.M., Matyas J.R., Katzenberg M.A., and Hallgrimsson B. Comparison of microcomputed tomographic and microradiographic measurements of cortical bone porosity. Calcif. Tissue Int. 74 (2004) 437-447
13. Cooper D.M., Turinsky A.L., Sensen C.W., and Hallgrimsson B. Quantitative 3D analysis of the canal network in cortical bone by micro-computed tomography. Anat. Rec. 274B (2003) 169-179
14. Gruber H.E., Ashraf N., Kilburn J., Williams C., Norton H.J., Gordon B.E., et al. Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat. Spine 30 (2005) 2593-2600
15. Matsumoto T., Yoshino M., Asano T., Uesugi K., Todoh M., and Tanaka M. Monochromatic synchrotron radiation muCT reveals disuse-mediated canal network rarefaction in cortical bone of growing rat tibiae. J. Appl. Physiol. 100 (2006) 274-280
16. Cooper D.M., Thomas C.D., Clement J.G., and Hallgrimsson B. Three-dimensional microcomputed tomography imaging of basic multicellular unit-related resorption spaces in human cortical bone. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 288 (2006) 806-816
17. Filogamo G. La forme et la taille des osteones chez quelques Mammiferes. Arch. de Biol. 57 (1946) 137-143
18. Amprino R. A contribution to the functional meaning of the substitution of primary by secondary bone tissue. Acta Anat. 5 (1948) 291-300
19. Bertelsen P.K., Clement J.G., and Thomas C.D. A morphometric study of the cortex of the human femur from early childhood to advanced old age. Forensic Sci. Int. 74 (1995) 63-77
20. Black J., Mattson R., and Korostoff E. Haversian osteons: size, distribution, internal structure, and orientation. J. Biomed. Mater. Res. 8 (1974) 299-319
21. Currey J.D. Some effects of ageing in human Haversian systems. J. Anat. 98 (1964) 69-75
22. Jowsey J. Studies of Haversian systems in man and some animals. J. Anat. 100 (1966) 857-864
23. Feik S.A., Thomas C.D., and Clement J.G. Age-related changes in cortical porosity of the midshaft of the human femur. J. Anat. 191 Pt. 3 (1997) 407-416
24. Stein M.S., Feik S.A., Thomas C.D., Clement J.G., and Wark J.D. An automated analysis of intracortical porosity in human femoral bone across age. J. Bone Miner. Res. 14 (1999) 624-632
25. Bousson V., Bergot C., Meunier A., Barbot F., Parlier-Cuau C., Laval-Jeantet A.M., et al. CT of the middiaphyseal femur: cortical bone mineral density and relation to porosity. Radiology 217 (2000) 179-187
26. Bousson V., Meunier A., Bergot C., Vicaut E., Rocha M.A., Morais M.H., et al. Distribution of intracortical porosity in human midfemoral cortex by age and gender. J. Bone Miner. Res. 16 (2001) 1308-1317
27. Thomas C.D., Feik S.A., and Clement J.G. Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences. J. Anat. 206 (2005) 115-125
28. Thomas C.D.L., Feik S.A., and Clement J.G. Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone. J. Anat. 209 2 (2006) 219-230
29. Thomas C.D., Stein M.S., Feik S.A., Wark J.D., and Clement J.G. Determination of age at death using combined morphology and histology of the femur. J. Anat. 196 Pt. 3 (2000) 463-471
30. Ulrich D., van Rietbergen B., Laib A., and Ruegsegger P. The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone. Bone 25 (1999) 55-60
31. Cohen J., and Cohen P. Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. 2nd ed. (1983), Lawrence Erlbaum Associates, Publishers, London
32. Lewis D. Quantitative Methods in Psychology (1966), The University of Iowa, Iowa City
33. Pfeiffer S., Crowder C., Harrington L., and Brown M. Secondary osteon and Haversian canal dimensions as behavioral indicators. Am. J. Phys. Anthropol. (2006)
34. Martin R.B. On the significance of remodeling space and activation rate changes in bone remodeling. Bone 12 (1991) 391-400
35. Wildner M., Peters A., Raghuvanshi V.S., Hohnloser J., and Siebert U. Superiority of age and weight as variables in predicting osteoporosis in postmenopausal white women. Osteoporos. Int. 14 (2003) 950-956
36. Mohamed E.I., Tarantino U., Promenzio L., and De Lorenzo A. Predicting bone mineral density of postmenopausal healthy and cirrhotic Italian women using age and body mass index. Acta Diabetol. 40 Suppl. 1 (2003) S23-S28
37. Wehren L.E., and Siris E.S. Beyond bone mineral density: can existing clinical risk assessment instruments identify women at increased risk of osteoporosis?. J. Intern. Med. 256 (2004) 375-380
38. Barrett-Connor E., Siris E.S., Wehren L.E., Miller P.D., Abbott T.A., Berger M.L., et al. Osteoporosis and fracture risk in women of different ethnic groups. J. Bone Miner. Res. 20 (2005) 185-194
39. Cvijetic S., and Korsic M. Apparent bone mineral density estimated from DXA in healthy men and women. Osteoporos. Int. 15 (2004) 295-300
40. Camargo M.B., Cendoroglo M.S., Ramos L.R., de Oliveira Latorre Mdo R., Saraiva G.L., Lage A., et al. Bone mineral density and osteoporosis among a predominantly Caucasian elderly population in the city of Sao Paulo, Brazil. Osteoporos. Int. 16 (2005) 1451-1460
41. Lim S., Joung H., Shin C.S., Lee H.K., Kim K.S., Shin E.K., et al. Body composition changes with age have gender-specific impacts on bone mineral density. Bone 35 (2004) 792-798
42. Gilsanz V., Kovanlikaya A., Costin G., Roe T.F., Sayre J., and Kaufman F. Differential effect of gender on the sizes of the bones in the axial and appendicular skeletons. J. Clin. Endocrinol. Metab. 82 (1997) 1603-1607
43. van der Meulen M.C., Ashford Jr. M.W., Kiratli B.J., Bachrach L.K., and Carter D.R. Determinants of femoral geometry and structure during adolescent growth. J. Orthop. Res. 14 (1996) 22-29
44. Power J., Loveridge N., Lyon A., Rushton N., Parker M., and Reeve J. Osteoclastic cortical erosion as a determinant of subperiosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance. Effects of stance-related loading and hip fracture. Osteoporos. Int. 16 (2005) 1049-1056
45. Kaptoge S., Dalzell N., Loveridge N., Beck T.J., Khaw K.T., and Reeve J. Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone 32 (2003) 561-570
46. Russo C.R., Lauretani F., Seeman E., Bartali B., Bandinelli S., Di Iorio A., et al. Structural adaptations to bone loss in aging men and women. Bone 38 (2006) 112-118
47. Chandler P.J., and Bock R.D. Age changes in adult stature: trend estimation from mixed longitudinal data. Ann. Hum. Biol. 18 (1991) 433-440
48. Borkan G.A., Hults D.E., and Glynn R.J. Role of longitudinal change and secular trend in age differences in male body dimensions. Hum. Biol. 55 (1983) 629-641
49. Lieberman D.E., Pearson O.M., Polk J.D., Demes B., and Crompton AW. Optimization of bone growth and remodeling in response to loading in tapered mammalian limbs. J. Exp. Biol. 206 (2003) 3125-3138
50. Bell K.L., Loveridge N., Reeve J., Thomas C.D., Feik S.A., and Clement J.G. Super-osteons (remodeling clusters) in the cortex of the femoral shaft: influence of age and gender. Anat. Rec. 264 (2001) 378-386