Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone

Journal of Anatomy

Volumn 209, Issue 2, 2006, Pages 219-230

  Thomas, C David L ^a   Feik, Sophie A ^a   Clement, John G ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Bone ageing; Femoral cortex; Intracortical porosity; Midshaft; Pore number

Indexed keywords

ADULT; AGE; AGED; AGING; ARTICLE; AUSTRALIA; BONE AGE; BONE DENSITY; BONE STRUCTURE; CORTICAL BONE; FEMALE; FEMUR; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMAGE PROCESSING; MALE; MICRORADIOGRAPHY; NORMAL HUMAN; NORMAL VALUE; OSTEOMETRY; POROSITY; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE;

ADULT; AGED; BONE DENSITY; BONE DEVELOPMENT; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FEMUR; HUMANS; MALE; MICRORADIOGRAPHY; MIDDLE AGED; POROSITY;

EID: 33746643312     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2006.00589.x     Document Type: Article

References (35)

1. Atkinson PJ (1965) Changes in resorption spaces in femoral cortical bone with age. J Path Bact 89, 173-178.
2. Beck TJ, Ruff CB, Scott WW, Plato CC, Tobin JD, Quan CA (1992) Sex differences in geometry of the femoral neck with aging: A structural analysis of bone mineral data. Calcif Tissue Int 50, 24-29.
3. Beck TJ, Ruff CB, Bissessur K (1993) Age-related changes in female femoral neck geometry: Implications for bone strength. Calcif Tissue Int 53 (Suppl. 1), S41-S46.
4. Beck T, Ruff C, Looker A, Mourtada F, Wahner H, Steiger P (1996) Ethnic and sex differences in age trends of proximal femur geometry from NHANES III hip DXA data. (Abstract). J Bone Miner Res 11, 61.
5. Bell K, Loveridge N, Power J, Rushton N, Reeve J (1999) Intracapsular hip fracture: Increased cortical remodeling in the thinned and porous anterior region of the femoral neck. Osteoporosis Int 10, 248-257.
6. Boereboom F, Raymakers J, de Groot R, Duursman S (1992) Epidemiology of hip fractures in the Netherlands: Women compared with men. Osteoporosis Int 2, 279-284.
7. Bousson V, Meunier A, Bergot C, et al. (2001) Distribution of intracortical porosity in human midfemoral cortex by age and gender. J Bone Miner Res 16, 1308-1317.
8. Cooper C, Campion G, Melton LJI (1992) Hip fractures in the elderly: A world-wide projection. Osteoporosis Int 2, 285-289.
9. Cooper DML, Matyas JR, Katzenberg MA, Hallgrimsson B (2004) Comparison of microcomputed tomographic and microradiographic measurements of cortical bone porosity. Calcified Tissue Int 74, 437-447.
10. De Laet CE, van Hout BA, Burger H, Hofman A, Pols HA (1997) Bone density and risk of hip fracture in men and women: Cross sectional analysis. Br Med J 315, 221-225.
11. Dickenson R, Hutton W, Stott J (1981) The mechanical properties of bone in osteoporosis. J Bone Joint Surg 63-B, 233-238.
12. Feik SA, Thomas CDL, Clement JG (1997) Age-related changes in cortical porosity of the midshaft of the human femur. J Anat 191, 407-416.
13. Feik S, Thomas C, Bruns R, Clement J (2000) Regional variations in cortical modeling in the femoral mid-shaft: Sex and age differences. Am J Phys Anthropol 112, 191-205.
14. Hazelwood SJ, Martin RB, Rashid MM, Rodrigo Juan J (2001) A mechanistic model for internal bone remodeling exhibits different dynamic responses in disuse and overload. J Biomech 34, 299-308.
15. Johnston CC, Norton J, Khairi MRA, et al. (1985) The heterogeneity of fracture syndrome in postmenopausal women. J Clin Endocrinol Metab 61, 551-556.
16. Jowsey J (1960) Age changes in human bone. Clin Orthop 17, 210-217.
17. Martin RB, Pickett JC, Zinaich S (1980) Studies of skeletal remodeling in aging men. Clin Orthop 149, 268-282.
18. Martin RB, Burr DB (1984) Mechanical implications of porosity distribution in bone of the appendicular skeleton. Orthop Trans 8, 342-343.
19. Mayhew PM, Thomas CD, Clement JG, et al. (2005) Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 366, 129-135.
20. McCalden RW, McGeough JA, Barker MB, Court-Brown CM (1993) Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralisation and microstructure. J Bone Joint Surg 75 - A, 1193-1205.
21. Melton LJ (1993) Hip fractures; a worldwide problem today and tomorrow. Bone 14, S1-S8.
22. Myers ER, Hecker AT, Rooks DS, Hipp JA, Hayes WC (1993) Geometric variables from DXA of the radius predict forearm fracture load in vitro. Calcif Tissue Int 52, 199-204.
23. Pollard AW, Feik SA, Storey E (1984) Remodeling of bone and bones -effects of translation and strain on transplants. Br J Exp Pathol 65, 655-670.
24. Ruff CB, Hayes W (1988) Sex differences in age-related remodeling of the femur and tibia. J Orthop Res 6, 886-896.
25. Schaffler M, Burr D (1988) Stiffness of compact bone: Effects of porosity and density. J Biomech 21, 13-16.
26. Seeman E, Edmonds J, Kotowicz M, Nicholson G, Cumming RG, Martin TJ (1993) The Incidence of Hip Fractures in Women and Men in Australia. Queenstown, New Zealand: Australian and New Zealand Bone and Mineral Society.
27. Simmons ED, Pritzker KPH, Grynpas MD (1991) Age-related changes in the human femoral cortex. J Orthop Res 9, 155-167.
28. Stein MS, Feik SA, Thomas CDL, Clement JG, Wark JD (1999) An automated analysis of intracortical porosity in human femoral bone across age. J Bone Miner Res 14, 624-632.
29. Terrier A, Rakotomanana RL, Ramaniraka AN, Leyvraz PF (1997) Adaptation models of anisotropic bone. Comput Meth Biomech Biomed Engin 1, 47-59.
30. Thomas CDL, Feik SA, Clement JG (2005) Regional variation of intracortical porosity in the midshaft of the human femur: Age and sex differences. J Anat 206, 115-125.
31. Wachter NJ, Augat P, Krischak GD, et al. (2001) Prediction of srength of cortical bone in vitro by microcomputed tomography. Clin Biomech 16, 252-256.
32. Wachter NJ, Krischak GD, Mentzel M, et al. (2002) Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro. Bone 31, 90-95.
33. Wall JC, Chatterji SK, Jeffery JW (1979) Age-related changes in the density and tensile strength of human femoral cortical bone. Calcif Tissue Int 27, 105-108.
34. Yeni YN, Brown CU, Wang Z, Norman TL (1997) The influence of bone morphology on fracture toughness of the human femur and tibia. Bone 21, 453-459.
35. Yeni YN, Brown CU, Norman TL (1998) Influence of bone composition and apparent density on fracture toughness of the human femur and tibia. Bone 22, 79-84.