Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Brazilian Journal of Medical and Biological Research

Volumn 39, Issue 11, 2006, Pages 1483-1491

  Pagno, T ^a   Blind, L Z ^a   Biavatti, M W ^a   Kreuger, Maria Regina O ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Antitumoral; Ehrlich ascitic tumor; Leaf extract; Neutrophils; Vernonia scorpioides

Indexed keywords

DICHLOROMETHANE; FLUOROURACIL; PLANT EXTRACT; UNCLASSIFIED DRUG; VERNONIA SCORPIOIDES EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTERACEAE; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; CYTOTOXICITY; DRUG DOSE COMPARISON; EHRLICH ASCITES TUMOR; EHRLICH ASCITES TUMOR CELL; HISTOPATHOLOGY; IN VITRO STUDY; INFLAMMATION; LEUKOCYTE COUNT; LIFESPAN; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEAL CAVITY; PLANT LEAF; SOLID TUMOR; SPLEEN; TUMOR CELL; VERNONIA;

ANIMALIA; ASTERACEAE; MUS; VERNONIA;

EID: 33847686808     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2006001100012     Document Type: Article

References (31)

1. Cabrera AL, Klein RM. Compostas: Tribo: Vernoniae. FI Ilustr Catarin 1980; 3: 354-355.
2. Freire MFI, Abreu HS, Cruz LCH, Freire RB. Inhibition of fungal growth by extracts of Vernonia scorpioides (Lam.) Pers. Microbiology 1996; 27: 1-6.
3. Leite SN, Palhano G, Almeida S, Biavatti MW. Wound healing activity and systemic effects of Vernonia scorpioides extract in guinea pig. Fitoterapia 2002; 73: 496-500.
4. Monteiro MH, Gomes-Carneiro MR, Felzenszwalb I, Chahoud I, Paumgartten FJ. Toxicological evaluation of a tea from leaves of Vernonia condensata. J Ethnopharmacol 2001; 74: 149-157.
5. Mazumder UK, Gupta M, Manikandan L, Bhattacharya S, Haldar PK, Roy S. Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats. Phytomedicine 2003; 10: 185-188.
6. Iwalewa EO, Iwalewa OJ, Adeboye JO. Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf. J Ethnopharmacol 2003; 86: 229-234.
7. Gupta M, Mazumder UK, Manikandan L, Haldar PK, Bhattacharya S, Kandar CC. Antibacterial activity of Vernonia cinerea. Fitoterapia 2003; 74: 148-150.
8. Izevbigie EB. Discovery of water-soluble anticancer agents from a vegetable found in Benin city, Nigeria. Exp Biol Med 2003; 228: 293-298.
9. Izevbigie EB, Bryant JL, Walker A. A novel natural inhibitor of extracellular signal-regulated kinases and human breast cancer cell growth. Exp Biol Med 2004; 229: 163-169.
10. Lambertini E, Piva R, Khan MT, Lampronti I, Bianchi N, Borgatti M, et al. Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int J Oncol 2004; 24: 419-423.
11. Howard CB, Stevens J, Izevbigie EB, Walker A, McDaniel O. Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent. Cell Mol Biol 2003; 49: 1057-1065.
12. Abosi AO, Raseroka BH. In vivo antimalarial activity of Vernonia amygdalina. Br J Biomed Sci 2003; 60: 89-91.
13. Muregi FW, Chhabra SC, Njagi EN, Lang'at-Thoruwa CC, Njue WM, Orago AS, et al. In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects. J Ethnopharmacol 2003; 84: 235-239.
14. Krishna Kumari GN, Masilamani S, Ganesh MR, Aravind S, Sridhar SR. Zaluzanin D: a fungistatic sesquiterpene from Vernonia arborea. Fitoterapia 2003; 74: 479-482.
15. Kuo YH, Kuo YJ, Yu AS, Wu MD, Ong CW, Yang Kuo LM, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull 2003; 51: 425-426.
16. Koul JL, Koul S, Singh C, Taneja SC, Shanmugavel M, Kampasi H, et al. In vitro cytotoxic elemanolides from Vernonia lasiopus. Planta Med 2003; 69: 164-166.
17. Campos M, Oropeza M, Ponce H, Fernandez J, Jimenez-Estrada M, Torres H, et al. Relaxation of uterine and aortic smooth muscle by glaucolides D and E from Vernonia liatroides. Biol Pharm Bull 2003; 26: 112-115.
18. Huang Y, Ding ZH, Liu JK. A new highly oxygenated flavone from Veronia saligna. Z Naturforsch [C] 2003; 58: 347-350.
19. Tchinda AT, Tane P, Ayafor JF, Connolly JD. Stigmastane derivatives and isovaleryl sucrose esters from Vernonia guineensis (Asteraceae). Phytochemistry 2003; 63: 841-846.
20. Nergard CS, Diallo D, Michaelsen TE, Malterud KE, Kiyohara H, Matsumoto T, et al. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J Ethnopharmacol 2004; 91: 141-152.
21. Matsuzaki P, Akisue G, Salgado Oloris SC, Gorniak SL, Zaidan Dagli ML. Effect of Pfaffia paniculata (Brazilian ginseng) on the Ehrlich tumor in its ascitic form. Life Sci 2003; 74: 573-579.
22. Christina AJ, Alwin JM, Heison Robert SJ, Kothai R, Chidambaranathan N, Muthumani P. Effect of Indigofera aspalathoides against Dalton's ascitic lymphoma. Fitoterapia 2003; 74: 280-283.
23. Blanco JG, Gil RR, Bocco JL, Meragelman TL, Genti-Raimondi S, Flury A. Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone. J Pharmacol Exp Ther 2001; 297: 1099-1105.
24. Miglietta A, Bozzo F, Gabriel L, Bocca C. Microtubule-interfering activity of parthenolide. Chem Biol Interact 2004; 149: 165-173.
25. Lin BF, Chiang BL, Lin JY. Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro. Int Immunopharmacol 2005; 5: 711-722.
26. Duong Van Huyen JP, Delignat S, Bayry J, Kazatchkine MD, Bruneval P, Nicoletti A, et al. Interleukin-12 is associated with the in vivo anti-tumor effect of mistletoe extracts in B16 mouse melanoma. Cancer Lett 2006.
27. Jisaka M, Ohigashi H, Takegawa K, Huffman MA, Koshimizu K. Antitumoral and antimicrobial activities of bitter sesquiterpene lactones of Vernonia amygdalina, a possible medicinal plant used by wild chimpanzees. Biosci Biotechnol Biochem 1993; 57: 833-834.
28. Tchinda AT, Tsopmo A, Tane P, Ayafor JF, Connolly JD, Sterner O. Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae). Phytochemistry 2002; 59: 371-374.
29. Tona L, Cimanga RK, Mesia K, Musuamba CT, De Bruyne T, Apers S, et al. In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. J Ethnopharmacol 2004; 93: 27-32.
30. Hordegen P, Hertzberg H, Heilmann J, Langhans W, Maurer V. The anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs. Vet Parasitol 2003; 117: 51-60.
31. Sur P, Das M, Gomes A, Vedasiromoni JR, Sahu NP, Banerjee S, et al. Trigonella foenum graecum (fenugreek) seed extract as an anti-neoplastic agent. Phytother Res 2001; 15: 257-259.