A Novel Natural Inhibitor of Extracellular Signal-Regulated Kinases and Human Breast Cancer Cell Growth

Experimental Biology and Medicine

Volumn 229, Issue 2, 2004, Pages 163-169

  Izevbigie, Ernest B ^a   Bryant, Joseph L ^b   Walker, Alice ^a  

^a Jackson State University   (United States)

^b INSTITUTE OF HUMAN VIROLOGY   (United States)

Author keywords

DNA synthesis; ERKs activities; Human breast cancer; V. amygdalina extract

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTINEOPLASTIC AGENT; DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PLANT EXTRACT; UNCLASSIFIED DRUG; VERNONIA AMYGDALINA EXTRACT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; ENZYME INHIBITION; GROWTH RATE; HUMAN; HUMAN CELL; PLANT LEAF; VERNONIA;

MINK CELL FOCUS-FORMING VIRUS; VERNONIA; VERNONIA AMYGDALINA;

EID: 0742270544     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020422900205     Document Type: Article

References (46)

1. Jemal A, Thomas A, Murray T, Thun M. Cancer statistics. CA Cancer J Clin 52:23-47, 2002.
2. Abdulaev FI. Plant-derived agents against cancer. In: Gupta SK, Ed. Pharmacology and Therapeutics in the New Millennium. New Delhi: Narosa Publishing House, pp345-354, 1993.
3. Richardson MA. Biopharmacologic and herbal therapies for cancer: research update from NCCAM. J Nutr 131(11S):3037S-3040S, 2001.
4. Pezzuto JM. Plant-derived anticancer agents. Biochem Pharmacol 53:121-133, 1997.
5. Zeegers MP, Goldbohm RA, Van den Brandt PA. Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiol Biomarkers Prev 10:1121-1128, 2001.
6. Kobayashi T, Nakata T, Kuzumaki T. Effect of flavonoids on cell cycle progression in prostate cancer cells. Cancer Lett 176:17-23, 2000.
7. Block G, Patterson B, Subar A. Fruits, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18:1-29, 1992.
8. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci. U S A 94:10367-10372, 1997.
9. Singletary K. Natural products and cancer chemoprevention. J Nutr 130:465-466, 2000.
10. Dragsted L, Srube M, Larsen J. Cancer-preventive factors in fruits and vegetables: biochemical and biological background. Pharmacol Toxicol 72(suppl. 1):116-135, 1993.
11. Maoka T, Mochida K, Kozuka M, Ito Y, Fujiwara Y, Hashimoto K, Enjo F, Ogata M, Nobukuni Y, Tokuda H, Nishino H. Cancer chemopreventive activity of carotenoids in the fruits of red paprika capsicum annuum L. Cancer Lett 172:103-109, 2001.
12. Littman AJ, Beresford SA, White E. The association of dietary fat and plant foods with endometrial cancer (United States). Cancer Causes Control 12:691-702, 2001.
13. Terry P, Lagergren J, Hansen H, Wolk A, Nyren O. Fruits and vegetables consumption in the prevention of esophageal and cardiac cancers. Eur J Cancer Prev 10:365-369, 2001.
14. Rock CL, Moskowitz A, Huizar B, Saenz CC, Clark JT, Daly TL, Chin H, Behling C, Ruffin MT 4th. High vegetable and fruit diet intervention in premenopausal women with cervical intraepithelial neoplasia. J Am Diet Assoc 101:1167-1174, 2001.
15. Simopoulos AP. The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence. J Nutr 131(11 Suppl):3065S-3073S, 2001.
16. Heber D, Bowerman S. Applying science to changing dietary patterns. J Nutr 131(11 Suppl):3078S-3081S, 2001.
17. Tatman D, Mo H. Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells. Cancer Lett 175:129-139, 2002.
18. Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzuto JM, Kong AN. Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol Pharmacol 60:217-224, 2001.
19. Meta-Greenwood E, Ito A, Westenburg H, Cui B, Mehta RG, Kinghorn AD, Pezzuto JM. Discovery of novel inducers of cellular differentiation using HL-60 promyelocyte cells. Anticancer Res 21:1763-1770, 2001.
20. Bhal KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61:7456-7463, 2001.
21. Jang M, Pezzuto JM. Effects of resveratrol on 12-o-tetradecanolylphorbol-13- acetale-induced oxidative events and gene expression in mouse skin. Cancer Lett 134:81-89, 1998.
22. Jang M, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Drugs Exp Clin Res 25:65-77, 1999.
23. Song LL, Kosmeder JW, Lee SK, Gerhauser C, Lantvit D, Moon RC, Moriarty RM, Pezzuto JM. Cancer chemopreventive activity mediated by 4′ -bromoflavone, a potent inducer of phase II detoxification enzyme. Cancer Res 59:578-585, 1999.
24. Tan GT, Lee S, Lee IS, Chen J, Leitner P, Besterman JM, Kingkong AD, Pezzuto JM. Natural-product inhibitors of human DNA ligase 1. Biochem J 313(pt 3):993-1000, 1996.
25. Udeani GO, Gerhauser C, Thomas CF, Moon RC, Kosmeder JW, Kingkong AD, Moriarty RM, Pezzuto JM. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res 57:3424-3428, 1997.
26. Talalay P, Fahey JW, Holtzclaw WD, Prestera T, Zhang Y. Chemoprotection against cancer by phase 2 enzyme induction. Toxicol Lett 82-83:173-179, 1995.
27. Talalay P. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12:5-11, 2000.
28. Talalay P, Talalay P. The importance of using scientific principles in the development of medicinal agents from plants. Acad Med 76:238-247, 2001.
29. Talalay P, Fahey JW. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr 131(11 Suppl):3027S-3033S, 2001.
30. Wargovich MJ, Wood C, Hollis DM, Zander ME. Herbals, cancer prevention and health. J Nutr 131:3034S-3036S, 2001.
31. Olayiwole A. WHO guidelines for the assessment of herbal medicines. ESCOP Symposium: the Scientific Assessment of Phytomedicines, March 13, 1992. Milan, Italy: Fitoterapia 1:XIII(2), 1992.
32. Kupchan SM, Hemingway RJ, Karim A, Werner D. Tumor inhibitors. XLVII. Vernodalin and vernomygdin. Two new cytotoxic sesquiterpene lactones from Vernonia amygdalina Del. J Org Chem 34:3908-3911, 1969.
33. Jisaka M, Ohigashi H, Takegawa K, Huffman MA, Koshimizu K. Antitumoral and antimicrobial activities of bitter sesquiterpene lactones of Vernonia amygdalina, a possible medical used by wild chimpanzees. Biosci Biochem 57:833-834, 1993.
34. Obaseiki-Ebor EE, Odukoya K, Telikepalli H, Mitscher LA, Shankel D. Antimutagenic activity of extracts of leaves of four common edible vegetable plants in Nigeria (West Africa). Mutat Res 302:109-117, 1993.
35. Izevbigie EB. Discovery of water-soluble anticancer agents (edotides) from a vegetable found in Benin City, Nigeria. Exp Biol Med 228:293-298, 2003.
36. Atanaskova N, Keshamouni VG, Krueger JS, Schwartz JA, Miller F, Reddy KB. MAP Kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene 21:4000-4008, 2002.
37. Liu XM, Wang LG, Kreis W, Budman DR, Adams LM. Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells. Br J Cancer 85:1403-1411, 2001.
38. Mandlekar S, Kong AN. Mechanisms of tamoxifen apoptosis. Apoptosis 6:469-477, 2001.
39. Adeyinka A, Nui Y, Cherlet T, Snell L, Watson PH, Murphy LC. Activated mitogen-activated protein kinase expression during human breast tumorigenesis and progression. Clin Cancer Res 8:1747-1753, 2002.
40. Campbell MJ, Hamilton B, Shoemaker M, Tagliaferri M, Cohen I, Tripathy D. Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro. Anticancer Res 22:3843-3852, 2002.
41. Cobb MH, Boulton TG, Robbins DJ. Extracellular signal-regulated kinases: ERKs in progress. Cell Regul 2:965-978, 1991.
42. Ray LB, Sturgill TW. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylate microtubule-associated protein 2 in vitro. Proc Natl Acad Sci U S A 84:1502-1506, 1987.
43. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556, 1993.
44. Wang Z, Wang S, Zhu F, Ye Y, Yu Y, Qiao X. Expression of extracellular signal-regulated kinase and its relationship with clinicopathological characteristics of breast cancer. Zhonghua Zhong Liu Za Zhi 24:360-363, 2002.
45. Deguchi H, Fuji T, Nakagawa S, Koga T, Shirouzu K. Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D. Int J Oncol 21:1301-1305, 2002.
46. Uhegbu FO. Dietary secondary amines and liver hepatoma in Port Harcourt, Nigeria. Plant Foods Hum Nutr 51:257-263, 1997.