Manufacturing drug loaded chitosan microspheres by spray drying: Development, characterization, and potential use in dentistry

Drying Technology

Volumn 25, Issue 2, 2007, Pages 303-310

  Braga, Gláucia K ^a   Oliveira, Wanderley P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Drugs; Microencapsulation; Spray drying; Sustained release

Indexed keywords

DENTISTRY; DISSOLUTION; DRUG PRODUCTS; MICROSPHERES; MORPHOLOGY; SIZE DISTRIBUTION;

CHITOSAN; KETOPROFEN; MICROENCAPSULATION POLYMER; SUSTAINED-RELEASE DRUG-LOADED MICROPARTICLES;

SPRAY DRYING;

DENTISTRY; DISSOLUTION; DRUG PRODUCTS; MICROSPHERES; MORPHOLOGY; SIZE DISTRIBUTION; SPRAY DRYING;

EID: 33847686256     PISSN: 07373937     EISSN: 15322300     Source Type: Journal    
DOI: 10.1080/07373930601119672     Document Type: Article

References (32)

1. Vyas, S. P., Sihorkar, V. and Mishra, V. (2000) Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. Journal of Clinical Pharmacy & Therapeutics, 25:1, pp. 21-42.
2. Ishida, M., Nambu, N. and Nagai, T. (1982) Mucosal dosage form of lidocaine for toothache using hydroxypropyl cellulose and carbopol. Chemical and Pharmaceutical Bulletin, 30, pp. 980-984.
3. Elkayan, R., Friedman, M., Stabholz, A., Soskolne, A., Sela, M. N. and Golub, L. (1988) Sustained release device containing minocycline for local treatment of periodontal disease. Journal of Controlled Release, 7, pp. 231-236.
4. Nagai, T. (1985) Adhesive topical drug delivery system. Journal of Controlled Release, 2, pp. 121-134.
5. Jalil, R. and Nixon, J. R. (1990) Biodegradable poly(lactide acid) and poly (lactide-co-glycolide) microcapsules: Problems associated with preparative techniques and release properties. Journal of Microencapsulation, 7, pp. 297-325.
6. Oakley, D. E. (1997) Produce uniform particles by spray-drying. Chemical Engineering Progress, 93, pp. 48-54.
7. Masters, K. (1985) Spray Drying Handbook, George Godwin, Ltd., London
8. Ré, M. I. (1998) Microencapsulation by spray-drying. Drying Technology, 16:6, pp. 1195-1236.
9. Muzzarelli, R. A. A. (1973) Natural Chelating Polymers: Alginic Acid, Chitin, and Chitosan;, pp. 83-252. Pergamon Press, New York
10. Azzam, T. and Domb, A. J. (2005) Polymeric Gene Delivery: Principles and Applications;, CRC Press, New York
11. Morimoto, M., Saimoto, H. and Shigemasa, Y. (2002) Control of functions of chitin and chitosan by chemical modification. Trends in Glycoscience & Glycotechnology, 14:78, pp. 205-222.
12. Singla, A. K. and Chawla, M. (2001) Chitosan: Some pharmaceutical and biological aspects: An update. Journal of Pharmacy & Pharmacology, 53:8, pp. 1047-1067.
13. Janes, K. A., Calvo, P. and Alonso, M. J. (2001) Polysaccharide colloidal particles as delivery systems for macromolecules. Advanced Drug Delivery Reviews, 47:1, pp. 83-97.
14. Adamiec, J. and Modrzejewska, Z. (2005) Some structural properties of spray dried chitosan microgranules. Drying Technology, 23, pp. 1601-1611.
15. Senel, S., Ikinci, G., Kas, S., Yousefi-Rad, A., Sargon, M. F. and Hincal, A. A. (2000) 2000. Chitosan films and hydrogels of chlorexidini gluconate for oral mucosal delivery. International Journal of Pharmaceutics, 193, pp. 197-203.
16. Genta, I., Perugini, P., Modena, T., Pavanetto, F., Castelli, F., Muzzarelli, R. A. A., Muzzarelli, C. and Conti, B. (2003) Miconazole-loaded 6-oxychitin-chitosan microcapsules. Carbohydrate Polymers, 52:1, pp. 11-18.
17. Bernardo, M. V., Blanco, M. D., Sastre, R. L., Teijón, C. and Teijón, J. M. (2003) Sustained release of bupivacaine from devices based on chitosan. Il Farmaco, 58, pp. 1187-1191.
18. Averbuch, M. and Katzper, M. (2000) Baseline pain and response to analgesic medications in the postsurgery dental pain model. Journal of Clinical Pharmacology, 40:2, pp. 133-137.
19. Olson, N. Z., Otero, A. M., Marrero, I., Tirado, S., Cooper, S., Doyle, G., Jayawardena, S. and Sunshine, A. (2001) Onset of analgesia for liquid ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. Journal of Clinical Pharmacology, 41:11, pp. 1238-1247.
20. Lawrence, H. P., Paquette, D. W., Smith, P. C., Maynor, G., Wilder, R., Mann, G. L., Binder, T., Troullos, E., Annett, M., Friedman, M. and Offenbacher, S. (1998) Pharmacokinetics and safety evaluation of ketoprofen gels in subjects with adult periodontitis. Journal of Dental Research, 77:11, pp. 1904-1912.
21. Dionne, R. A., Gordon, S. M., Tahara, M., Rowan, J. and Troullos, E. (1999) Analgesic efficacy and pharmakinetics of ketoprofen administered into surgical site. Journal of Clinical Pharmacology, 39:2, pp. 131-138.
22. Paquette, D. W., Lawrence, H. P., McCombs, G. D., Wilder, R., Binder, T. A., Troullos, E., Friedman, M., Smith, P. C. and Offenbacher, S. (2000) Pharmacodynamics of ketoprofen on crevicular fluid prostanoids in adult periodontitis. Journal of Clinical Periodontology, 27:8, pp. 558-566.
23. (2001) Pharmaceutical Engineering Guides for New and Renovated Facilities, 5, ISPE, Tampa, Florida
24. (2004) General and Current Good Manufacturing Practice for Finished Pharmaceuticals, Rockville, Maryland
25. (2003) Diário Oficial da União, Brazil
26. Çomoglu, T., Gönül, N. and Baykara, T. (2003) Preparation and in vitro evaluation of modified release ketoprofen microsponges. Il Farmaco, 58, pp. 101-106.
27. Bolton, S. (1997) Practical and Clinical Applications, Marcel Dekker Inc., New York
28. (2004) United States Pharmacopeia, United States Pharmacopeial Convention, Inc., Rockville, MD
29. Muzzarelli, C., Muzzarelli, R. A. A. and Giunchedi, P. (1899) Spray-dried microspheres of chitosan-polyuronan complexes for drug delivery. Control Release Society, 31st Annual Meeting
30. Oliveira, B. I., Santana, M. H. A. and Ré, M. I. (1899) Spray-dried chitosan cross-linked with D,L-glyceraldehyde as a potential drug delivery system. Preparation and characterization. Proceedings of the 14th International Drying Symposium 2004, pp. 1166-1173.
31. Santos, J. E., Soares, J. P. and Dockal, E. R. (2003) Caracterização de quitosanas comerciais de diferentes origens. Polímeros. Ciência e Tecnologia, 3:4, pp. 242-249.
32. Zambito, Y. and Colo, G. Di (2003) Preparation and in vitro evaluation of chitosan matrices for colonic controlled drug delivery. Journal of Pharmacy and Pharmaceutical Sciences, 6:2, pp. 274-281.