Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell lines

Journal of Veterinary Medical Science

Volumn 69, Issue 2, 2007, Pages 111-115

  Nakaichi, Munekazu ^a   Takeshita, Yoko ^a   Okuda, Masaru ^a   Nakamoto, Yuya ^a   Itamoto, Kazuhito ^a   Satoshi, U N E ^a   Sasaki, Nobuo ^b   Kadosawa, Tsuyoshi ^c   Takahashi, Tomoko ^d   Taura, Yasuho ^a  

^a YAMAGUCHI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c RAKUNO GAKUEN UNIVERSITY   (Japan)

^d NIHON UNIVERSITY   (Japan)

Author keywords

Canine mast cell tumor; Cellular chemosensitivity; MDR1; P glycoprotein

Indexed keywords

FLUORESCENT DYE; GLYCOPROTEIN P; RHODAMINE 123; VERAPAMIL;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; DOG; DOG DISEASE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENETICS; MASTOCYTOMA; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DOG DISEASES; DOGS; FLOW CYTOMETRY; FLUORESCENT DYES; GENE EXPRESSION; GENES, MDR; MASTOCYTOMA; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHODAMINE 123; VERAPAMIL;

EID: 33847680416     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.69.111     Document Type: Article

References (27)

1. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. and Gottesman, M. M. 1999. Biochemical cellular and pharmacological aspects of multidrug transporter. Annu. Rev. Phamacol. Toxicol. 39: 361-398.
2. Bergman, P. J., Ogilvie, G.K. and Powers, B.E. 1996. Monoclonal antibody C219 immunohistochemistry against P-glycoprotein: sequential analysis and predictive ability in dogs with lymphoma. J. Vet. Intern. Med. 10: 354-359.
3. Bostock, D.E. 1986. Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br. Vet. J. 142: 1-19.
4. Campos, L., Guyotat, D., Archimbauld, E., Calmard-Oriol, P., Tsuruo, T., Troncy, J., Treille, D. and Fiere, D. 1992. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 79: 473-476.
5. Conrad, S., Viertelhaus, A., Orzechowski, A., Hoogstraate, J., Gjellan, K., Schrenk, D. and Kauffmann, H-M. 2001. Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1. Toxicol. 156: 81-91.
6. Dean, M., Hamon, Y. and Chimini, G. 2001. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 42: 1007-1017.
7. Dean, M., Rzhetsky, A. and Allikmets, R. 2001. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11: 1156-1166.
8. Gottesman, M. M., Fojo, T. and Bates S.E. 2002. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer. 2: 48-58.
9. Illmer, T., Schaich, M., Platzbecker, U., Freiberg-Richter, J., Oelschlägel, U., Bonin, M., Pursce, S., Bergemann, T., Ehninger, G. and Schleyer, E. 2004. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 18: 401-408.
10. Ishiguro, T., Kadosawa, T., Mori, K., Takagi, S., Okumura, M. and Fujinaga, T. 2001. Establishment and characterization of a new canine mast cell tumor cell line. J. Vet. Med. Sci. 63: 1031-1034.
11. Lee, J.J., Hughes, C.S. and Fine, R.L. 1996. P-glycoprotein expression in canine lymphoma. Cancer 77: 1892-1898.
12. Marie, J. P., Zittoun, R. and Sikic, B. I. 1991. Multidrug resistance (MDR1) gene expression in adult acute leukemias: Correlations with treatment out come and in vitro drug sensitivity. Blood 78: 586-592.
13. Mealey, K. L., Bentjen, S. A., Gay, J. M. and Cantor, G. H. 2001. Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene. Pharmacogenetics 11: 727-733.
14. Moor, A. S., Leveille, C. R., Reimann, K. A., Shu, H. and Arias, I. M. 1995. The expression of P-glycoprotein in canine lymphoma and its association with multidrug resistance. Cancer Invest. 13: 475-479.
15. Nakaichi, M., Taura, Y., Knki, M., Mamba, K., Momoi, Y., Tsujimoto, H. and Nakama, S. 1996. Establishment of a new canine B-cell leukemia cell line. J. Vet. Med. Sci. 58: 469-471.
16. Noonan, K. B. C., Holzmayer, T., Chin, J., Wunder, J., Andrulis, I., Gazdar, A., Willman, C., Griffith, B., VonHoff, D. and Roninson, I. 1990. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc. Natl. Acad. Sci. U.S.A. 87: 7160-7164.
17. Pirker, R., Wallner, J., Geissler, K., Linkesch, W., Haas, O. A., Bettelheim, P., Hopfner, M., Scherrer, R., Valent, P., Haveloc, L., Ludwig, H. and Lechner, K. 1991. MDR1 gene expression and treatment outcome in acute myeloid leukemia. J. Natl. Cancer. Inst. 83: 708-712.
18. Poeta, G. D., Venditti, A., Stasi, R., Aronica, G., ChristinaCox, M., Buccisano, F., Tamburini, A., Bruno, A., Maurillo, L., Battaglia, A., Suppo, G., Epiceno, A. M., Moro, B. D., Masi, M., Amadori, S. and Papa, G. 1999. P-glycoprotein and terminal transferase expression identify prognostic subsets within cytogenetic risk classes in acute myeloid leukemia. Leukemia Res. 23: 451-465.
19. Rothwell, T. L., Howlett, C. R., Middleton, D. J., Griffiths, D. A. and Duff, B. C. 1987. Skin neoplasmas of dogs in Sydney. Aust .Vet. J. 64: 161-164.
20. Roulet, A., Puel, O., Gesta, S., Lepage, J. F., Drag, M., Soll, M., Alvinerie, M. and Pineau, T. 2003. MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur. J. Pharmacol. 460: 85-91.
21. Steingold, F. S., Sharp, J. S., Mcgahan, C. M., Hughes, S. C., Dunn, E. S. and Page, L. R. 1998. Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo. Anticancer Res. 18: 393-400.
22. Tafuri, A., Gregorj, C., Petrucci, M. T., Ricciardi, M. R., Mancini, M., Cimino, G., Mecucci, C., Tedeschi, A., Fioritoni, G., Ferrara, F., Raimondo, F. D., Gallo, E., Liso, V., Fabbiano, F., Cascavilla, N., Pizzolo, G., Camera, A., Pane, F., Lanza, F., Cilloni, D., Annino, L., Vitale, A., Vegna, M.L., Vignetti, M., Foà, R. and Mandelli, F. 2002. MDR1 protein expression is an independent predictor of complete remmision in newly diagnosed acute lymphoblastic leukemia. Blood 100: 974-981.
23. Takahashi, T., Kadosawa, T., Nagase, M., Mochizuki, M., Matsunaga, S., Nishimura, R. and Sasaki, N. 1997. Inhibitory effects of glucocorticoids on proliferation of canine mast cell tumor. J. Vet. Med. Sci. 59: 995-1001.
24. Thamm, D.H., Mauldin, E.A. and Vail, D.M. 1999. Predonisone and vinblastine chemotherapy for canine mast cell tumor. 41 cases (1992-1998). J. Vet. Intern. Med. 13: 491-497.
25. Thomas, H. and Coley, H. M. 2003. Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibition P-glycoprotein. Cancer Control 10: 159-165.
26. Uozumi, K., Nakaichi, M., Yamamoto, Y., Une, S. and Taura, Y. 2005. Development of multidrug resistance in a canine lymphoma cell line. Res. Vet. Science 78: 217-224.
27. Withrow, S. J. and MacEwen, E. G. 2001. Small Animal Clinical Oncology, 3rd. ed., Saunders, Philadelphia.