Sex differences in the potency of κ opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats

Psychopharmacology

Volumn 191, Issue 2, 2007, Pages 273-285

  Lomas, Lisa M ^a   Barrett, Andrew C ^a   Terner, Jolan M ^a   Lysle, Donald T ^a   Picker, Mitchell J ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

Capsaicin; Kappa opioid; Mixed action opioid; NMDA; Peripheral opioid receptor; Sex differences

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BUTORPHANOL; CAPSAICIN; DEXTROMETHORPHAN; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALBUPHINE; NORBINALTORPHIMINE; SPIRADOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; FEMALE; HYPERALGESIA; INFLAMMATION; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; THERMAL STIMULATION;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; CAPSAICIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPERALGESIA; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; MALE; N-METHYLASPARTATE; PAIN; PAIN MEASUREMENT; RATS; RATS, INBRED F344; RECEPTORS, OPIOID; SEX FACTORS;

EID: 33847673638     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0663-1     Document Type: Article

References (41)

1. Antonijevic I, Mousa AS, Schafer M, Stein C (1995) Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci 15:165-172
2. Barrett AC (2006) Low efficacy opioids: implications for sex differences in opioid antinociception. Exp Clin Psychopharmacol 14:1-11
3. Barrett AC, Smith ES, Picker MJ (2002) Sex-related differences in mechanical nociception and antinociception produced by μ- and κ-opioid receptor agonists in rats. Eur J Pharmacol 452:163-173
4. Barrett AC, Smith ES, Picker MJ (2003) Capsaicin-induced hyperalgesia and mu opioid-induced antihyperalgesia in male and female rats. J Pharmacol Exp Ther 307:237-245
5. Binder W, Carmody J, Walker J (2000) Effect of gender on antiinflammatory and analgesic actions of two κ-opioids. J Pharmacol Exp Ther 292:303-309
6. Butelman ER, Ko M-C, Sobczyk-Kojiro K, Mosberg HI, van Bemmel B, Zernig G, Woods JH (1998) Kappa-opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception. J Pharmacol Exp Ther 285:595-601
7. Clemente JT, Parada CA, Veiga MC, Gear RW, Tambeli CH (2004) Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint. Neurosci Lett 372:250-255
8. Cook CD, Nickerson MD (2005) Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and females rats. J Pharmacol Exp Ther 313:449-459
9. Cook CD, Barrett AC, Roach EL, Bowman JR, Picker MJ (2000) Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity and efficacy at the μ opioid receptor. Psychopharmacology 150:430-442
10. Craft RM (2003) Sex differences in opioid analgesia: "from mouse to man". Clin J Pain 19:175-186
11. Craft RM, Bernal SA (2001) Sex differences in opioid antinociception: kappa and 'mixed action' agonists. Drug Alcohol Depend 63:215-228
12. Craft R, Lee D (2005) NMDA antagonist modulation of morphine antinociception in female vs. male rats. Pharmacol Biochem Behav 80:639-649
13. Danysz W, Essmann U, Bresink R (1994) Glutamate antagonists have different effects on spontaneous locomotor activity in rats. Pharmacol Biochem Behav 48:111-118
14. Dykstra LA (1990) Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey. J Pharmacol Exp Ther 214:245-252
15. Eisenberg E, Vos BP, Strassman AM (1993) The NMDA antagonist memantine blocks pain behavior in a rat model of formalin induced facial pain. Pain 54:301-307
16. Falcon M, Guendellman D, Stolberg A, Frenk H, Urca G (1996) Development of thermal nociception in rats. Pain 67:203-208
17. Holtman JR Jr, Wala EP (2006) Characterization of the antinociceptive effect of oxycodone in male and female rats. Pharmacol Biochem Behav 83:100-108
18. Holtman JR Jr, Jing X, Wala EP (2003) Sex related differences in the enhancement of morphine antinociception by NMDA receptor antagonists in rats. Pharmacol Biochem Behav 76:285-293
19. Holzer P (1991) Capsaicin: cellular targets, mechanisms of action and selectivity for thin sensory neurons. Pharmacol Rev 43:143-201
20. Ji RR, Zhang Q, Law PY, Low HH, Elde R, Hokfelt T (1995) Expression of mu, delta and kappa opioid receptor like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J Neurosci 15:8156-8166
21. Joshi SK, Gebhart GF (2003) Nonopioid actions of U50,488 enantiomers contribute to their peripheral cutaneous antinociceptive effects. J Pharmacol Exp Ther 305:919-924
22. Kavaliers M, Choleris E (1997) Sex differences in N-methyl-D-aspartate involvement in κ opioid and non-opioid predator-induced analgesia in mice. Brain Res 768:30-36
23. Kavaliers M, Galea L (1995) Sex differences in the expression and antagonism of swim stress-induced analgesia in deer mice vary with the breeding season. Pain 63:327-334
24. Ko MCH, Johnson MD, Butelman ER, Willmont KJ, Mosberg HI, Woods JH (1999) Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys. J Pharmacol Exp Ther 291:1113-1120
25. Ko MCH, Tuchman JE, Johnson MD, Wiesanuer K, Woods JH (2000) Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats. Psychopharmacology 148:180-185
26. Kumor KM, Haertzen CA, Johnson RE, Kocher T, Jasinski D (1986) Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo. J Pharmacol Exp Ther 238:960-968
27. Le Bars D, Gozariu M, Cadden SW (2001) Animal models of nociception. Pharmacol Rev 53:597-652
28. McCall WD, Tanner KD, Levine JD (1996) Formalin induces biphasic activity in C-fibers in the rat. Neurosci Lett 208:45-48
29. Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KVS, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, Grisel JE, Fillingim RB (2003) The melanocortin-1 receptor gene mediates female specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci USA 100:4867-4872
30. Nishimura W, Tadatoshi M, Tatsumi S, Sakimura K, Mishina M, Minami T, Ito S (2004) Characterization of N methyl-D-aspartate receptor subunits responsible for post operative pain. Eur J Pharmacol 503:71-75
31. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic, San Diego
32. Plesan A, Hedman U, Xu X-J, Wiesenfeld-Hallin Z (1998) Comparison of ketamine and dextromethorphan in potentiating the antinociceptive effect of morphine in rats. Anesth Analg 86:825-829
33. Przewlocki R, Przewlocka B (2001) Opioids in chronic pain. Eur J Pharmacol 429:79-91
34. Redwine KE, Trujillo KA (2003) Effects of NMDA receptor antagonists on acute opioid analgesia in the rat Pharmacol Biochem Behav 76:361-372
35. Richardson JD, Vasko MR (2002) Cellular mechanisms of neurogenic inflammation J Pharmacol Exp Ther 302:839-845
36. Rimoy GH, Bhaskar NK, Wright DM, Rubin PC (1991) Mechanism of diuretic action of spiradoline (U-62066E)-a kappa opioid receptor agonist in the human. Br J Clin Pharmacol 32:611-615
37. Sakurada R, Wako K, Sguiyama A, Sakurada C, Tan-Ho K, Kisara K (1998) Involvement of spinal NMDA receptors in capsaicin-induced nociception. Pharmacol Biochem Behav 59:339-345
38. Sternberg WF, Chesler EJ, Wilson SG, Mogil JS (2004) Acute progesterone can recruit sex-specific neurochemical mechanisms mediating swim stress-induced and kappa-opioid analgesia in mice. Horm Behav 46:467-473
39. Tallarida RJ, Murray RB (1987) Manual of pharmacologic calculations with computer programs. Springer, Berlin Heidelberg New York
40. Yaksh TL (1997) Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 41:94-111
41. Zollner C, Shaqura MA, Bopaiah CP, Mousa S, Stein C, Schafer M (2003) Painful inflammation-induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol Pharmacol 64:202-210