Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: Effects of repeated administration

Experimental Brain Research

Volumn 178, Issue 1, 2007, Pages 115-125

  Gilbert, Trevor H ^a   Teskey, G Campbell ^b  

^a ATHABASCA UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Afterdischarge threshold; Antiepileptic drugs; Behavioral toxicity; Epilepsy

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN DEPTH STIMULATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOCAL EPILEPSY; GUINEA PIG; KINDLING; MALE; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; RATING SCALE; REPEAT PROCEDURE; REPEATED DRUG DOSE; SEDATION; SEIZURE; TREATMENT DURATION;

ACTION POTENTIALS; AMYGDALA; ANIMALS; ANTICONVULSANTS; BRAIN; CARBAMAZEPINE; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; ELECTRIC STIMULATION; EPILEPSIES, PARTIAL; ETHOSUXIMIDE; FEMALE; GUINEA PIGS; KINDLING, NEUROLOGIC; MALE; PHENOBARBITAL; PHENYTOIN; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SPECIES SPECIFICITY; TREATMENT OUTCOME; VALPROIC ACID;

EID: 33847666406     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-006-0716-z     Document Type: Article

References (46)

1. Albertson TE, Peterson SL, Stark LG (1980) Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats. Neuropharmacology 19:643-652
2. Albertson TE, Joy RM, Stark LG (1984) Carbamazepine: a pharmacological study in the kindling model of epilepsy. Neuropharmacology 23:1117-1123
3. Albright PS, Burnham WM (1980) Development of a new pharmacological seizure model: effects of anticonvulsants on cortical-and amygdala-kindled seizures in the rat. Epilepsia 21(6):681-689
4. Bourgeois BFD (1996) Phenobarbital and primidone. In: Wyllie E (ed) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, pp 845-855
5. Cavazos JE, Cross DJ (2006) The role of synaptic reorganization in medial temporal lobe epilepsy. Epilepsy Behav 8(3):483-493
6. Dean JC (1996) Valproate. In: Wyllie E (eds) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, pp 824-832
7. Dziki M, Hönack D, Löscher W (1992) Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate. Eur J Pharmacol 222(2-3):273-278
8. Engel J (1998) The syndrome of mesial temporal lobe epilepsy: a role for kindling. In: Corcoran ME, Moshe SL (eds) Kindling 5. Plenum Press, New York, pp 469-484
9. Gilbert TH, Teskey GC (2001) Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute carbamazepine. Exp Br Res 140:479-485
10. Gilbert TH, Bharadia V, Teskey GC (2001) Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute phenytoin. Exp Br Res 140:469-478
11. Gilbert TH, Corley SM, Teskey GC (2002) Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide. Exp Br Res 146:336-344
12. Goddard GV (1967) Development of epileptic seizures through brain stimulation at low intensity. Nature 214:1020-1021
13. Goddard GV, McIntyre DC, Leetch CK (1969) A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 25:295-330
14. Graves NM, Ramsay RE (1996) Phenytoin and fosphenytoin. In: Wyllie E (ed) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, pp 833-844
15. Hönack D, Löscher W (1989) Amygdala-kindling as a model for chronic efficacy studies on antiepileptic drugs: experiments with carbamazepine. Neuropharmacology 28(6):599-610
16. Hönack D, Löscher W (1995) Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs. Epilepsia 36(8):763-771
17. Hönack D, Wahnschaffe U, Löscher W (1991) Kindling from stimulation of a highly sensitive locus in the posterior part of the piriform cortex. Comparison with amygdala kindling and effects of antiepileptic drugs. Brain Res 538:196-202
18. Howe SJ, Salt TE, Tulloch I, Walter DS (1980) Effect of anti-grand mal drugs on kindled epilepsy in the rat. Br J Pharmacol 72:501P-502P
19. Löscher W, Hönack D (1989) Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala kindled rats. Eur J Pharmacol 162(2):309-322
20. Löscher W, Hönack D (1993) Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats. Eur J Pharmacol 234(2-3):237-245
21. Löscher W, Schmidt D (1994) Strategies in antiepileptic drug development: is rational drug design superior to random drug screening and structural variation? Epilepsy Res 17:95-134
22. Löscher W, Schmidt D (2002) New horizons in the development of antiepileptic drugs. Epilepsy Res 50:3-16
23. Löscher W, Fisher JE, Nau H, Hönack D (1989) Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment. J Pharmacol Exp Therap 250(3):1067-1078
24. Löscher W, Cramer S, Ebert U (1998) Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats. Epilepsy Res 31:175-186
25. Luparello TJ (1967) Stereotaxic atlas of the forebrain of the guinea pig. Williams and Wilkins, Baltimore
26. Mace JA, Burnham WM (1987) The effect of repeated seizures on anticonvulsant drug response in the kindling model. Electroenceph Clin Neurophysiol 67(2):171-175
27. McIntyre DC, Poulter MO, Gilby K (2002) Kindling: some old and some new. Epilepsy Res 50:79-92
28. McNamara JO (1984) Kindling: an animal model of complex partial epilepsy. Ann Neurol 16(suppl):S72-S76
29. McNamara JO (1989) Development of new pharmacological agents for epilepsy: lessons from the kindling model. Epilepsia 30(Suppl 1):S13-S18
30. McNamara JO, Rigsbee LC, Butler LS, Shin C (1989) Intravenous phenytoin is an effective anticonvulsant in the kindling model. Ann Neurol 26(5):675-678
31. Morimoto K, Sato H, Sato K, Sato S, Yamada N (1997) BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. Eur J Pharmacol 339:11-15
32. Otsuki K, Morimoto K, Sato K, Yamada N, Kuroda S (1998) Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in rats. Epilepsy Res 31(2):101-112
33. Pallini R, Palestini M, Lauretti L, Rossi GF (1989) Effect of magnesium valproate on amygdala-kindled seizures in the rat: comparison with sodium valproate. Neurol Res 11(1):17-23
34. Rundfeldt C, Löscher W (1993) Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats. J Pharmacol Exp Ther 266(1):216-223
35. Rundfeldt C, Honack D, Löscher W (1990) Phenytoin potently increases the threshold for focal seizures in amygdala-kindled rats. Neuropharmacology 29(9):845-851
36. Sato M, Racine RJ, McIntyre DC (1990) Kindling: basic mechanisms and clinical validity. Electroenceph Clin Neurophysiol 76:459-472
37. Sillanpää M (1996) Carbamazepine. In: Wyllie E (ed) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, pp 808-823
38. Silver JM, Shin C, McNamara JO (1991) Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy. Ann Neurol 29:356-363
39. Sutula TP (2004) Mechanisms of epilepsy progression: current theories and perspectives from neuroplasticity in adulthood and development. Epilepsy Res 60:161-171
40. Teskey GC, Valentine PA, Sainsbury RS, Trepel C (1995) Evolution of afterdischarge and seizure characteristics during electrical kindling of the guinea pig. Brain Res 672:137-147
41. Teskey GC, Valentine PA, Trepel C (1996) Arrest of seizure progression during electrical kindling in guinea-pigs with prior pentylenetetrazol-induced convulsions. Epilepsy Res 24:101-107
42. Teskey GC, Thiessen EJ, Gilbert TH (1999) Alternate-site kindling in the guinea-pig results in accelerated seizure progression and generalization. Epilepsy Res 34:151-159
43. Voits M, Frey HH (1994) Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischarges. Pharmacol Toxicol 75:54-61
44. White HS (2003) Preclinical development of antiepileptic drugs: past present, and future directions. Epilepsia 44(Suppl 7):2-8
45. Wolff D (1996) Ethosuximide. In: Wyllie E (ed) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, pp 856-864
46. Young NA, Lewis SJ, Harris QLG, Jarrott B, Vajda FJE (1987) The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat. Neuropharmacology 26(11):1611-1614