A new efficient synthesis of N-(2-(2-(3-methoxy-4-(oxazol-5-yl)phenylamino) oxazol-5-yl)phenyl)-N-methyl-2-morpholinoacetamide (BMS-337197), a novel IMPDH inhibitor

Arkivoc

Volumn 2007, Issue 12, 2007, Pages 36-42

  Zhao, Rulin ^a   Chen, Bang Chi ^a   Bednarz, Mark S ^a   Wang, Bei ^a   Skoumbourdis, Amanda P ^a   Sundeen, Joseph E ^a   Dhar, T G Murali ^a   Iwanowicz, Edwin J ^a   Balasubramanian, Balu ^a   Barrish, Joel C ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

2 Aminooxazole; Cyclization; IMPDH inhibitor; Isothiocyanate; azidoketone

Indexed keywords

EID: 33847656945     PISSN: 1551-7012     EISSN: 14246376     Source Type: Journal    
DOI: 10.3998/ark.5550190.0008.c03     Document Type: Article

References (6)

1. Jackson, R. C.; Weber, G.; Morris, H. P. Nature 1975, 256, 331.
2. Pankiewicz, K. W. Expert Opin. Ther. Pat. 2001, 11, 1161.
3. Dhar, T. G. M.; Shen, Z.; Guo, J.; Liu, C.; Watterson, S. H.; Gu, H. H.; Pitts, W. J.; Fleener, C. A.; Rouleau, K. A.; Sherbina, N. Z.; McIntyre, K. W.; Witmer, M. R.; Tredup, J. A.; Chen, B.-C.; Zhao, R.; Bednarz, M. S.; Cheney, D. L.; MacMaster, J. F.; Miller, L. M.; Berry, K. K.; Harper, T. W.; Barrish, J. C.; Hollenbaugh, D. L.; Iwanowicz, E. J. J. Med. Chem. 2002, 45, 2127.
4. 2, see: Ehrenfreund, J.; Zbiral, E. Tetrahedron 1972, 28, 1697.
5. Navas, F.; Bishop, M. J.; Garrison, D. T.; Hodson, S. J.; Speake, J. D.; Bigham, E. C.; Drewry, D. H.; Saussy, D. L.; Liacos, J. H.; Irving, P. E.; Gobel, M. J. Bioorg. Med. Chem. Lett. 2002, 12, 575.
6. Dhar, T. G. M.; Quo, J.; Shen, Z.; Pitts, W. J.; Gu, H. H.; Chen, B.-C.; Zhao, R.; Bednarz, M. S.; Iwanowicz, E. J. Org. Lett. 2002, 12, 2091.