Sublingual immunotherapy: An update on immunologic and functional effects

Allergy and Asthma Proceedings

Volumn 28, Issue 1, 2007, Pages 40-43

  Ciprandi, Giorgio ^a,b,f   Fenoglio, Daniela ^a,c   Cirillo, Ignazio ^a,c   Tosca, Mariangela A ^a,d   La Rosa, Mario ^a,e   Licari, Amelia ^a,e   Marseglia, Alessia ^a,e   Barberi, Salvatore ^a,b   Marseglia, Gian Luigi ^a,e  

^a University Hospital San Martino ^*

^b UNIVERSITY OF GENOA   (Italy)

^c La Spezia Hospital   (Italy)

^d G GASLINI INSTITUTE   (Italy)

^e FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

Author keywords

Eosinophils; IL 10 production; Immunologic tolerance; Regulatory T cells; Sublingual immunotherapy

Indexed keywords

ALLERGEN; CYTOKINE; IL10 PROTEIN, HUMAN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; UNCLASSIFIED DRUG;

BRONCHUS HYPERREACTIVITY; DESENSITIZATION; HAY FEVER; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METHODOLOGY; PERENNIAL RHINITIS; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; REVIEW; SUBLINGUAL DRUG ADMINISTRATION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADMINISTRATION, SUBLINGUAL; ALLERGENS; BRONCHIAL HYPERREACTIVITY; CYTOKINES; DESENSITIZATION, IMMUNOLOGIC; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; RESPIRATORY HYPERSENSITIVITY; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 33847649639     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: 10.2500/aap.2007.28.2974     Document Type: Review

References (46)

1. Frew AJ. Immunotherapy of allergic disease. J Allergy Clin Immunol 111:S712-S719, 2003.
2. Bousquet J, Lockey RF, and Mailing HJ. WHO position paper. Allergen immunotherapy: Therapeutic vaccines for allergic disease. Allergy 53(suppl 44):1-42, 1998.
3. Canonica GW, and Passalacqua G. Noninjection routes for immunotherapy. J Allergy Clin Immunol 111:437-448, 2003.
4. Mailing HJ, Abreo-Nogueira J, Alvarez-Cuesta E, et al. Local immunotherapy. Allergy 53:933-948, 1998.
5. Bousquet J, and Van Cauwenberg P. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108:S1-S315, 2001.
6. Passalacqua G, Lombardi C, and Canonica GW. Sublingual immunotherapy: An update. Curr Opin Allergy Clin Immnuol 4:31-36, 2004.
7. Wilson DR, Torres LI, and Durham SR. Sublingual immunotherapy for allergic rhinitis: Systematic review and meta-analysis. Allergy 60:4-12, 2005.
8. Akbari O, Stock P, DeKruiff RH, and Umetsu DT. Role of regulatory T cells in allergy and asthma. Curr Opin Immunol 15:627-633, 2003.
9. Herrick CA, and Bottomly K. To respond or not to respond: T cells in allergic asthma. Nat Rev Immunol 3:1-8, 2003.
10. Romagnani S. Regulatory T cells: Which role in the pathogenesis and treatment of allergic disorders. Allergy 61:3-14, 2006.
11. Jutel M, Akdis M, Budak F, et al. IL10 and TGFbeta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 33: 1205-1214, 2003.
12. Francis JN, Till SJ, and Durham SR. Induction of IL1o+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol 111:1255-1261, 2003.
13. Savolainen J, Laaksonen K, Rantio-Lehtimaki A, and Terho EO. Increased expression of allergen-induced in vitro interleukin-10 and interleukin-18 mRNA in peripheral blood mononuclear cells of allergic rhinitis patients after specific immunotherapy. Clin Exp Allergy 34:413-419, 2004.
14. Blaser K, and Akdis CA. Interleukin-10, T regulatory cells and specific allergy treatment. Clin Exp Allergy 34:328-331, 2004.
15. Ling EM, Smith T, Nguyen XD, et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 363:608-615, 2004.
16. Fenoglio D, Puppo F, Cirillo I, et al. Sublingual specific immunotherapy reduces PBMC proliferations. Allergol Immunol 37: 147-151, 2005.
17. Fanta C, Bohle B, Hirt W, et al. Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy. Int Arch Allergy Immunol 120:218-224, 1999.
18. Quanjer PhH, Tammeling GJ, Cotes JE, et al. Standardized lung function testing. Eur Respir J 6:1-99, 1993.
19. Bachert C, Van Kempen M, and Van Cauwenberge P. Regulation of proinflammatory cytokines in seasonal allergic rhinitis. Int Arch Allergy Immunol 118:375-379, 1999.
20. Kon OM, and Kay AB. T cells and chronic asthma. Int Arch Allergy Immunol 118:133-135, 1999.
21. Tang C, Inman MD, van Rooijen N, et al. Th type-1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism. J Immunol 166:1471-1481, 2001.
22. Hansen G, Berry G, Dekruiff RH, and Umetsu DT. Allergen specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 103:175-183, 1999.
23. Bach J. The effects of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347:911-920, 2002.
24. Jeannine P, Lecoanet S, Delneste Y, et al. IgE versus IgG4 production can be differentially regulated by IL-10. J. Immunol 160:3555-3561, 1998.
25. Royer B, Varadaradjalou S, Saas P, et al. Inhibition of IgE-induced activation of human mast cells by Il-10. Clin Exp Allergy 31:694-704, 2001.
26. Takanasi S, Nonaka R, Xing Z, et al. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. J Exp Med 180:711-715, 1994.
27. Groux H, Bigler M, de Vries JE, and Roncarolo MG. Interleukin-10 induces a long term antigen-specific anergic state in human CD4+ T cells. J Exp Med 184:19-29, 1996.
28. Bullens DMA, Van den Keybus, Dilissen E, et al. Allergen-specific T cells from birch-pollen-allergic patients and healthy controls differ in T helper 2 cytokine and in IL-10 production. Clin Exp Allergy 34:879-887, 2004.
29. Ippoliti F, De Santis W, Volterrani A, et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol 14:216-221, 2003.
30. Ciprandi G, Fenoglio D, Cirillo I, et al. Sublingual HDM-specific immunotherapy induces IL-10 production: Preliminary report. Ann Allergy Asthma Immunol 95:38-44, 2005.
31. Dehlink E, Eiwegger T, Gerstmayr M, et al. Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children. Clin Exp Allergy 36:32-39, 2006.
32. Cosmi L, Santarlasci V, Angeli R, et al. Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma and interleukin-10- production. Clin Exp Allergy 36:261-272, 2006.
33. Ciprandi G, Cirillo I, Vizzaccaro A, et al. Nasal obstruction in patients with seasonal allergic rhinitis: Relationships between allergic inflammation and nasal airflow. Int Arch Allergy Immunol 134:34-40, 2004.
34. Ciprandi G, Vizzaccaro A, Cirillo I, et al. Nasal eosinophils display the best correlation with symptoms, pulmonary function, and inflammation in allergic rhinitis. Int Arch Allergy Immunol 136:266-272, 2005.
35. Ciprandi G, Cirillo I, Klersy C, et al. Nasal obstruction is the key symptom in hay fever patients. Otolaryngol Head Neck Surg 133:429-435, 2005.
36. Kern EB. Committee report on standardization of rhinomanometry. Rhinology 19:231-269. 1981.
37. Ciprandi G, Cirillo I, Vizzaccaro A, et al. Decongestion test in patients with allergic rhinitis: Functional evaluation of nasal airflow. Am J Rhinol 20(2):224-226, 2006.
38. Ciprandi G, Cirillo I, Klersy C, et al. The response to decongestion test is associated with sensitizations and allergic inflammation. Ann Allergy Asthma Immunol 96:431-436, 2006.
39. Ciprandi G, Cirillo I, Klersy C, et al. Nasal airflow recovery after decongestion test is associated with bronchial hyperreactivity in patients with allergic rhinitis. Otolaryngol Head Neck Surg 134:255-259, 2006.
40. Ciprandi G, Fenoglio D, Cirillo I, et al. SLIT and Tregs. Allergy 61:511, 2006.
41. Ciprandi G, Cirillo I, Vizzaccaro A, et al. Early bronchial airflow impairment in patients with persistent allergic rhinitis and bronchial hyperreactivity. Respir Med 99:1606-1612, 2005.
42. 25-75 and skin test sensitization, nasal inflammation, and bronchial hyperreactivity in young subjects without asthma. Int J Allergy Asthma Immunol 4:258-261, 2005.
43. Ciprandi G, Cirillo I, Tosca MA, and Vizzaccaro A. Bronchial hyperreactivity and spirometric impairment in patients with seasonal allergic rhinitis. Respir Med 98:826-831, 2004.
44. Ciprandi G, Cirillo I, Vizzaccaro A, et al. Seasonal and perennial allergic rhinitis: Is this classification adherent to real life? A population based study. Allergy 60:882-887, 2005.
45. Ciprandi G, Cirillo I, Fenoglio D, et al. Sublingual immunotherapy induces spirometric improvement associated with IL-10 production: Preliminary reports. Int Immunopharmacol 6:1370-1373, 2006.
46. Ciprandi G, Cirillo I, Tosca MA, et al. Sublingual immunotherapy-induced IL-10 production is associated with changed response to the decongestion test: Preliminary results. Allergy Asthma Proc. (in press).